Protein Alignment ZnT33D and slc30a8

DIOPT Version :10

• Sequence 1: NP_723732.2
• Gene: ZnT33D / 326167
• FlyBaseID: FBgn0051860
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: XP_068071438.1
• Gene: slc30a8 / 560642
• ZFINID: ZDB-GENE-060315-10
• Length: 675
• Species: Danio rerio
• Alignment Length: 684
• Identity: 219/684 - (32%)
• Similarity: 329/684 - (48%)
• Gaps: 131/684 - (19%)

  Fly     3 KKSLKR-----QDEHTKDNDCEEEDEEELQAAIREMVKIPDIDIIPRKSSESVREKESTGNVLKK 62
            ||.|.|     |:....:||.              :.|:.|:..:.:|:.:...|:      :|.
Zfish   101 KKHLGRVLSIWQERAVYENDI--------------LDKLADVLQVEKKAQKRPYEE------IKV 145

  Fly    63 NHDERGSQTGDGK--DTTSKTRQ-KKLESDDSWAALLRKRFAWTKDNKTDAVNQNIPNTKGSSKD 124
            |.|:...|:...:  .|....|. ::||:..|..|.||||.:        |:...:.:|....|
Zfish   146 NVDDFACQSSPAEPPQTADLIRTLQELENAASSDAALRKRIS--------ALPPEVQDTSLLHK- 201

  Fly   125 FTENKGSGNKHSTVTSNEKLIRSEYYENSQTKSDAIKSLSNNQLSEESPEFLNKLR--RIEEASK 187
             .::|.||.:.|.:.....::.::|......:.|     ...||:.....||...|  .::...|
Zfish   202 -VQDKESGERLSRLVEEACMLLADYSGRLAAEID-----DRRQLTRTLAVFLQSQRDGLVQNEQK 260

  Fly   188 PKTWKRPTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPFQSNLYYVPEKPSR 252
            .:.:||      |..:.....|...:.|:..|..:.....|.|   .:::|...:||    .||
Zfish   261 LEEYKR------KLARVSQVRKELRSRLNGLPDLSRLPNVTGG---HMRLPSSGDLY----SPS- 311

  Fly   253 QDKGSGTSDFQPGAPETPIVENSAVDSDRKAVEIMPENVKNSEEKKIDNSDSTKTVTITGHSHIT 317
                                            :.||         .:|..|..
Zfish   312 --------------------------------DCMP---------SVDMKDGK------------ 323

  Fly   318 AKWDGHCH-------FKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLL 375
                 |||       .:|||   .|.|::.|.|...:|.:|::.|::||..:.|||:.|||||||
Zfish   324 -----HCHDNNRALEDRERE---KKIAKKRLYIVSAVCLVFMVGEILGGYFAGSLAVMTDAAHLL 380

  Fly   376 TDLASFLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFEL 440
            .||.||:||:.:|.|:.||::..|||||||||::||::|||.||:|||:|||:|:.|.:|.:|.:
Zfish   381 VDLTSFIISLCSLWLSSRPATRTLNYGWHRAEILGALLSIFTIWLVTGVLVYLAVERIINDNFTI 445

  Fly   441 DAKIMLITSALAILFNVIMAMQLQ---HGHSH-SLPGVHKMSKDAGSVLGSKMILLLGKSVSMQY 501
            :..:|||||..|:|.|:|||:.|.   ||||| .|...|..|.|.|...|..........|..|.
Zfish   446 EGTVMLITSGCAVLANIIMALTLHQSGHGHSHGGLSAGHGHSHDHGKENGHSHSDGSHHDVEEQR 510

  Fly   502 AAKGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRD 566
            ..|...|.:||||.:||:||::||..|.|:||||||.||:...|.:|||:||:.||..||.|:||
Zfish   511 PGKTQANASVRAAFVHVIGDLLQSISVLVSALIIFFKPEYKIADPICTFLFSLFVLGTTFTIMRD 575

  Fly   567 VLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAISKDADPQLILEEA 631
            :::||||.||..::|.||:|..|.:.||:.||||.||||::|:..||||:|..:..|||.:|.|.
Zfish   576 IVIVLMEGTPAGVNYNEVRQLLLGVKGVKAVHNLHIWALTMNQAVLSAHVATDETVDPQEVLREM 640

  Fly   632 TTLIHKRFKFFETTIQIEEYSPGMENCGQCLSPS 665
            |.:...::.|...|||:|..:....:|..|..|:
Zfish   641 TQVCFTKYSFHSVTIQLEPQADQRPDCSLCQDPA 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CzcD	312..649	CDD:440843	158/347 (46%)
slc30a8	XP_068071438.1	CID_RPRD1A	4..129	CDD:340808	9/41 (22%)
		CREPT	163..309	CDD:465181	35/173 (20%)
		CDF	355..660	CDD:273544	148/304 (49%)
		ureE	<469..505	CDD:237323	11/35 (31%)