DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT33D and Slc30a2

DIOPT Version :9

Sequence 1:	NP_723732.2	Gene:	ZnT33D / 326167	FlyBaseID:	FBgn0051860	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001034766.1	Gene:	Slc30a2 / 230810	MGIID:	106637	Length:	371	Species:	Mus musculus

Alignment Length:	348	Identity:	161/348 - (46%)
Similarity:	229/348 - (65%)	Gaps:	32/348 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HCHFKERETG-----VDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFL 382
            :|| .::::|     ..:.|||.|.:|..:|.:|:|.|:|||.|:.||||.|||||||||.||.|
Mouse    48 YCH-AQKDSGSHPDPEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAHLLTDFASML 111

  Fly   383 ISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLI 447
            ||:.||.::.||:::.:|:||||||::||::|:..||||||:|||:|:.|.::.|:|:....|||
Mouse   112 ISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQRLISGDYEIKGDTMLI 176

  Fly   448 TSALAILFNVIMAMQL-QHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQYAAKGHENINV 511
            ||..|:..|:||.:.| |.||.||    |..|:|..|                     ..:|.:|
Mouse   177 TSGCAVAVNLIMGLALHQSGHGHS----HGNSRDDSS---------------------QQQNPSV 216

  Fly   512 RAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRDVLMVLMEATP 576
            |||.|||:||::||.||.|||.||:|.||:.::|.:|||:||:|||..|..|||||::||||.||
Mouse   217 RAAFIHVIGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTP 281

  Fly   577 DFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAISKDADPQLILEEATTLIHKRFKF 641
            ..:|:..||...||:.|||.:|:|.||||::.:..||.|:||:::||.|.:|:.|...:..:|.|
Mouse   282 KGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNADAQAVLKVARDRLQGKFNF 346

  Fly   642 FETTIQIEEYSPGMENCGQCLSP 664
            ...|||||:||..|:||..|..|
Mouse   347 HTMTIQIEKYSEDMKNCQACQGP 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	145/301 (48%)
ZnT33D	NP_723732.2	Cation_efflux	350..572	CDD:279834	109/222 (49%)
Slc30a2	NP_001034766.1	CDF	79..356	CDD:273544	145/301 (48%)
Slc30a2	NP_001034766.1	Cation_efflux	79..277	CDD:279834	109/222 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2602
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2385
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	1	1.000	-	-		otm43512
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	O	PTHR11562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730