DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT33D and Slc30a4

DIOPT Version :9

Sequence 1:	NP_723732.2	Gene:	ZnT33D / 326167	FlyBaseID:	FBgn0051860	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_035904.2	Gene:	Slc30a4 / 22785	MGIID:	1345282	Length:	430	Species:	Mus musculus

Alignment Length:	495	Identity:	148/495 - (29%)
Similarity:	249/495 - (50%)	Gaps:	86/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 PKTWKR--------PTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPFQSNLY 244
            |..|||        .||:.|          |..:|.|...:.   ::|.....|.|:|....:..
Mouse     4 PGAWKRLKSLLRKDDTPLFL----------NDTSAFDFSDEV---SDEGLSRFNKLRVVVADDDS 55

  Fly   245 YVPEKPSRQDKGSGTSDFQPGA-PETPIVENSAVDSDRKAVEIMPENVKNSE-EKKIDNSDSTKT 307
            ..||:|..            || |.....::|.:|.|      :|  :.||: ..|:|..|:..
Mouse    56 EAPERPVN------------GAHPALQADDDSLLDQD------LP--LTNSQLSLKMDPCDNCS- 99

  Fly   308 VTITGHSHITAKWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAA 372
                               |.||....:..:..|.||.:|..:|:|.|::||.::|||||.|||.
Mouse   100 -------------------KRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDAL 145

  Fly   373 HLLTDLASFLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQD 437
            |:||||::.::::.||.|:.:..:.|..:|:||.||:.||:|:..::|:.|.|:|.|:.|.::.:
Mouse   146 HMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMN 210

  Fly   438 FELDAKIMLITSALAILFNVIMAMQL-QHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQY 501
            :|::..:||||:|:.:..||||...| |.||.||....|.:..::.|::.|      |.:
Mouse   211 YEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSS------GHN----- 264

  Fly   502 AAKGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRD 566
              .|.:::.||||.:|.:||::||.||.:||.||.|.||:...|.:||::||:||...||:|:.|
Mouse   265 --HGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWD 327

  Fly   567 VLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAI-----SKDADPQL 626
            .:::::|..|..::.:.:|::.:.|..|..|.:|.||:|:..|.....|:.:     ||..:.|
Mouse   328 TVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQ- 391

  Fly   627 ILEEATTLIHKRFKFFETTIQIEEY-SPGMENCGQCLSPS 665
              .:|..|:...|..::.|||::.| ...:..|..|.|.|
Mouse   392 --SKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSS 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	107/306 (35%)
ZnT33D	NP_723732.2	Cation_efflux	350..572	CDD:279834	86/222 (39%)
Slc30a4	NP_035904.2	CDF	123..414	CDD:273544	107/306 (35%)
		Cation_efflux	123..333	CDD:279834	86/222 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..264		4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2602
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710