DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT33D and Slc30a3

DIOPT Version :9

Sequence 1:	NP_723732.2	Gene:	ZnT33D / 326167	FlyBaseID:	FBgn0051860	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_035903.2	Gene:	Slc30a3 / 22784	MGIID:	1345280	Length:	388	Species:	Mus musculus

Alignment Length:	351	Identity:	146/351 - (41%)
Similarity:	221/351 - (62%)	Gaps:	26/351 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 HCHFKE--RETGVDK---AARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFL 382
            ||| |:  .::|:..   .|||.|..||.:|.||:..||:||.|::||||.|||||||.|:.|.|
Mouse    54 HCH-KDPVPQSGLSPERVQARRQLYAACAVCFIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSML 117

  Fly   383 ISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLI 447
            .|:.:|.|:.||::..:.:||||:|.:||:.|:..:|:|||||:|:|.:|.::.|:.::|..||:
Mouse   118 ASLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWIVTGILLYLAFLRLLHSDYHIEAGAMLL 182

  Fly   448 TSALAILFNVIMAMQL-QHG--HSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQYAAKGHENI 509
            |:::|:..|::||..| |.|  |||...|......:.|.          |..:|:       .|.
Mouse   183 TASIAVCANLLMAFVLHQTGAPHSHGSTGAEYAPLEEGH----------GYPMSL-------GNT 230

  Fly   510 NVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRDVLMVLMEA 574
            :||||.:||:||::|||||..|:::|:|.|::...|.:.||:||:..|..|...|||||:||||.
Mouse   231 SVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKVADPISTFLFSICALGSTAPTLRDVLLVLMEG 295

  Fly   575 TPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAISKDADPQLILEEATTLIHKRF 639
            .|..:::|.|:.|.||:.||...|:|.:|||::.....||||||...|||:.:|.||::.::.||
Mouse   296 APRSVEFEPVRDTLLSVPGVRATHDLHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRF 360

  Fly   640 KFFETTIQIEEYSPGMENCGQCLSPS 665
            .|...|:|:|:|.|.|..|.:|..||
Mouse   361 GFSSCTLQVEQYQPEMAQCLRCQEPS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	127/303 (42%)
ZnT33D	NP_723732.2	Cation_efflux	350..572	CDD:279834	93/224 (42%)
Slc30a3	NP_035903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		CDF	85..372	CDD:273544	127/303 (42%)
		Cation_efflux	85..293	CDD:279834	93/224 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842495
Domainoid	1	1.000	220	1.000	Domainoid score	I2602
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74470
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	1	1.000	-	-		otm43512
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	O	PTHR11562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.710