DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT33D and Slc30a10

DIOPT Version :9

Sequence 1:	NP_723732.2	Gene:	ZnT33D / 326167	FlyBaseID:	FBgn0051860	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001028458.1	Gene:	Slc30a10 / 226781	MGIID:	2685058	Length:	470	Species:	Mus musculus

Alignment Length:	369	Identity:	84/369 - (22%)
Similarity:	157/369 - (42%)	Gaps:	64/369 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 LIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFLISISALHLAGR-PSSERLNYGWH 404
            |:...:|...|.:.|::.|.|.||:|:.:|:.::|:||.|..:.:.:.::|.| |......||:.
Mouse    11 LLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRGSSATYGYV 75

  Fly   405 RAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLITSALAILFNVI----------- 458
            ||||:||:.:..|:..:...:...|::|....:...|.:::||..||.:..||:
Mouse    76 RAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGAC 140

  Fly   459 -----------MAMQLQHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSV--SMQYAA------- 503
                       .:.|...|......|..:.:..|.:......:.|.|.|.  ..|..|
Mouse   141 FSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVA 205

  Fly   504 -----------------KGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWP-------EW-AF 543
                             |..|.:|:|..::||:||.:.|..|.:.|:|.:..|       .| .:
Mouse   206 GDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCY 270

  Fly   544 MDSVCTFVFSVLVLVVTFKILRDVLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSIN 608
            :|...|.|..:::|...|.::::..::|::..|..::.||:.....::.|:..||.:.||.|...
Mouse   271 IDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSTVPGISSVHEVHIWELISG 335

  Fly   609 KVALSAHLAISKDADPQLILEEATTLIHKRFK---FFETTIQIE 649
            |:..:.|:...|..:.|    :|:..|.:.|.   ....|||.|
Mouse   336 KIIATLHIKHQKGTEYQ----DASRKIREIFHHAGIHNVTIQFE 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	82/360 (23%)
ZnT33D	NP_723732.2	Cation_efflux	350..572	CDD:279834	61/278 (22%)
Slc30a10	NP_001028458.1	CzcD	10..376	CDD:224151	84/369 (23%)
		Cation_efflux	20..299	CDD:279834	61/278 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..223		9/76 (12%)
		Required for plasma membrane localization. /evidence=ECO:0000250\|UniProtKB:Q6XR72	300..470		20/80 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740