DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tap42 and Igbp1

DIOPT Version :9

Sequence 1:	NP_723811.1	Gene:	Tap42 / 326166	FlyBaseID:	FBgn0051852	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_113812.1	Gene:	Igbp1 / 58845	RGDID:	62011	Length:	340	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	114/397 - (28%)
Similarity:	190/397 - (47%)	Gaps:	85/397 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGGEDQ----KLTDIFLKGWNIFDELEVTELPFNGSEFQNKVKTAMGLFEQATVIVNQVSMFSAN 67
            |..|::    :|.::|.....:.:||||...|......|:||...:.|.|:|..:::|:.:||.|
  Rat     2 AASEEELLLPRLPELFETSKKLLEELEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRN 66

  Fly    68 ELIDEVSTESLPFMLLPYFLGKLTTKINSPNNTHSIELGEIYFKDHLQRCQEYDL-------C-- 123
            |.::|:::..|.::::|...|.||.|..:|:..          .|||||.:|:.:       |
  Rat    67 EDLEEIASIDLKYLMVPALQGALTMKQVNPSKR----------LDHLQRAREHFIHFLTQCHCYH 121

  Fly   124 ----AAPKSQVAKADSQAEKSEQR--ELVEAAFNRNDKIAQYRRMKEIDEYMARMRDAVKNKTVD 182
                ..|:::...|::...:|...  .||..|..|..||.:|::.||::..::.::.||::...|
  Rat   122 VAEFQLPQTKNNSAENNTARSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQAD 186

  Fly   183 DEDKRVFFLKYLDKSIIDSKQELETLGVMKQLAQMRLARLAGGESDNEV------DSFRPPNQNQ 241
            ||..|.::|.:|.:.|..|.:|:|::                   |.|:      ||.|..:..|
  Rat   187 DERVREYYLLHLRRWIGISLEEIESI-------------------DQEIKILKDKDSPREESACQ 232

  Fly   242 SSASSTSRGHGHSHGPGHHHHHQQAAKPKPLQPFIITRNATQKAVFGLGYPSLPIMTVDEFYQQR 306
            ||...                     || |::|||:|||..|..|||.|||||..|||.::|:|.
  Rat   233 SSLPE---------------------KP-PMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQH 275

  Fly   307 VDEGIFPDEEKVAKMNQAQAIAAARDPNEKEDEEKAVEELQAEQDDPEYIDRMRRMDEYKDVVRR 371
            ...|..|| ..:||...|....||:   ::||:|:     :.|:::.:.:.|||..|::||...|
  Rat   276 QKYGALPD-RGIAKPPSADFQRAAQ---QQEDQEQ-----KDEENEEKALHRMREWDDWKDTHPR 331

  Fly   372 GDGNRHN 378
            |.|||.|
  Rat   332 GYGNRQN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tap42	NP_723811.1	TAP42	14..367	CDD:282084	104/373 (28%)
Igbp1	NP_113812.1	TAP42	17..329	CDD:282084	105/371 (28%)
		Interaction with PPP2CA. /evidence=ECO:0000250	99..203		27/113 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..242		9/42 (21%)
		Interaction with MID1. /evidence=ECO:0000250	226..291		32/87 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..340		23/67 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337314
Domainoid	1	1.000	136	1.000	Domainoid score	I4793
eggNOG	1	0.900	-	-		E1_KOG2830
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44067
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4314
OMA	1	1.010	-	-		QHG54512
OrthoDB	1	1.010	-	-		D1348942at2759
OrthoFinder	1	1.000	-	-		FOG0003127
OrthoInspector	1	1.000	-	-		otm46045
orthoMCL	1	0.900	-	-		OOG6_102570
Panther	1	1.100	-	-	LDO	PTHR10933
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2992
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770