DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tap42 and Igbp1

DIOPT Version :9

Sequence 1:	NP_723811.1	Gene:	Tap42 / 326166	FlyBaseID:	FBgn0051852	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_032810.4	Gene:	Igbp1 / 18518	MGIID:	1346500	Length:	340	Species:	Mus musculus

Alignment Length:	391	Identity:	111/391 - (28%)
Similarity:	188/391 - (48%)	Gaps:	73/391 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AGGEDQ----KLTDIFLKGWNIFDELEVTELPFNGSEFQNKVKTAMGLFEQATVIVNQVSMFSAN 67
            |..||:    :|.::|.....:.:::||...|......|:||...:.|.|:|..:::|:.:||.|
Mouse     2 AASEDELLLPRLPELFETSKKLLEDVEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRN 66

  Fly    68 ELIDEVSTESLPFMLLPYFLGKLTTKINSPNNTHSIELGEIYFKDHLQRCQEYDL-------C-- 123
            |.::|:::..|.::::|...|.||.|..:|:..          .|||||.:|:.:       |
Mouse    67 EDLEEIASTDLKYLMVPALQGALTMKQVNPSKR----------LDHLQRAREHFVHFLTQCHCYH 121

  Fly   124 ----AAPKSQVAKADSQAEKSEQR--ELVEAAFNRNDKIAQYRRMKEIDEYMARMRDAVKNKTVD 182
                ..|:::...|::....|...  .||..|..|..||.:|::.||::..::.::.||::...|
Mouse   122 VAEFQLPQTKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQAD 186

  Fly   183 DEDKRVFFLKYLDKSIIDSKQELETLGVMKQLAQMRLARLAGGESDNEVDSFRPPNQNQSSASST 247
            ||..|.:.|.:|.:.|..|.:|||::                   |.|:...:..:..:...:.
Mouse   187 DERVREYHLLHLRRWIAVSLEELESI-------------------DQEIKILKEKDSPREETAC- 231

  Fly   248 SRGHGHSHGPGHHHHHQQAAKPKPLQPFIITRNATQKAVFGLGYPSLPIMTVDEFYQQRVDEGIF 312
                 ||..|         .|| |::|||:|||..|..|||.|||||..|||.::|:|....|:.
Mouse   232 -----HSSLP---------EKP-PMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQKYGVL 281

  Fly   313 PDEEKVAKMNQAQAIAAARDPNEKEDEEKAVEELQAEQDDPEYIDRMRRMDEYKDVVRRGDGNRH 377
            || ..:||...|....||:   ::||:|:     :.|:.:.:.:.|||..|::||...||.|||.
Mouse   282 PD-RGIAKPASADFQRAAQ---QQEDQEQ-----KDEESEEKALHRMREWDDWKDTHPRGYGNRQ 337

  Fly   378 N 378
            |
Mouse   338 N 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tap42	NP_723811.1	TAP42	14..367	CDD:282084	100/367 (27%)
Igbp1	NP_032810.4	TAP42	17..329	CDD:282084	101/365 (28%)
		Interaction with PPP2CA. /evidence=ECO:0000250	99..203		27/113 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..242		6/34 (18%)
		Interaction with MID1. /evidence=ECO:0000250	226..291		31/81 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..340		19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833726
Domainoid	1	1.000	138	1.000	Domainoid score	I4817
eggNOG	1	0.900	-	-		E1_KOG2830
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44067
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4361
Isobase	1	0.950	-	0	Normalized mean entropy	S3266
OMA	1	1.010	-	-		QHG54512
OrthoDB	1	1.010	-	-		D1348942at2759
OrthoFinder	1	1.000	-	-		FOG0003127
OrthoInspector	1	1.000	-	-		otm43957
orthoMCL	1	0.900	-	-		OOG6_102570
Panther	1	1.100	-	-	LDO	PTHR10933
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1748
SonicParanoid	1	1.000	-	-		X2992
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750