DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31826 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001260473.1	Gene:	CG31826 / 326164	FlyBaseID:	FBgn0051826	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	280	Identity:	61/280 - (21%)
Similarity:	111/280 - (39%)	Gaps:	54/280 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QLRQLVEKCEDLRVGTEDTLLTKFLHYTRWDTIKAYQAIHDYYEFKRRH------PTWVARHPIE 78
            :|||.:::....::..::.:| :||....::..||.:.:.....::::|      .||.....:.
Mouse   261 RLRQWLQETHKGKIPKDEHIL-RFLRARDFNIDKAREIMCQSLTWRKQHQVDYILDTWTPPQVLL 324

  Fly    79 HYRQLFY--GTHCRYVMPQADRSGRVLVVFKTVDGFQDYPDYLQSLVEMDDLIFESLLL------ 135
            .|    |  |.|      ..|:.||.|.|.:.  |..|....:::|.|      |:||.
Mouse   325 DY----YAGGWH------HHDKDGRPLYVLRL--GQMDTKGLVRALGE------EALLRYVLSIN 371

  Fly   136 ---LPRVQQN---------GITVICDLQGTN-RNFLRQFSPAFMKVVNEKNGVLPFSQRIVHIIQ 187
               |.|.::|         ..|.:.||:|.| |:..|....|.::::.......|.:...:.|::
Mouse   372 EEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILR 436

  Fly   188 RGFLMHVTSTLFMPFMNKEFKEKIFTHDGRHL---SKLREMVGYESLPAEYGGPA-TNVLDTNLI 248
            ...:..|..||..||::...:.|...:.|...   ..|.:.:..|.:|....|.. .:|.:..|:
Mouse   437 APRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCDVPEGGLV 501

  Fly   249 FNHLSQNAEYLE----KLQT 264
            ...|.:.||.||    ||.|
Mouse   502 PKSLYRTAEELENEDLKLWT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31826	NP_001260473.1	CRAL_TRIO_N	17..61	CDD:215024	8/40 (20%)
CG31826	NP_001260473.1	CRAL_TRIO	92..237	CDD:279044	35/166 (21%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		54/267 (20%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	8/40 (20%)
		CRAL_TRIO	326..490	CDD:279044	39/181 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900