DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31826 and CLVS1

DIOPT Version :9

Sequence 1:	NP_001260473.1	Gene:	CG31826 / 326164	FlyBaseID:	FBgn0051826	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	286	Identity:	65/286 - (22%)
Similarity:	122/286 - (42%)	Gaps:	72/286 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IEQLRQLVEKCEDLR-VGTEDTLLTKFLHYTRWDTIKAYQAIHDYYEFKRRHPTWVARHPIEHYR 81
            |:|:|.::....|:. :.|:|..:.:||...::....|::.:..|::                ||
Human    53 IQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQ----------------YR 101

  Fly    82 QL----------------------FYGTHCRYVMPQADRSGRVLVVFKTVDGFQ---DYPDYLQS 121
            ||                      |.|     |:...|..||.:::....:..|   .:.|.|::
Human   102 QLNLDMFKNFKADDPGIKRALIDGFPG-----VLENRDHYGRKILLLFAANWDQSRNSFTDILRA 161

  Fly   122 LVEMDDLIFESLLLLPRVQQNGITVICDLQGTNRNFLRQFSPAFMKVVNEKNGVL-PFSQRI--V 183
            ::    |..|.|:..|.:|.||..:|.|....:.....:.:|:.:|:..|  |:. .|..|.  |
Human   162 IL----LSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIE--GLQDSFPARFGGV 220

  Fly   184 HIIQRGFLMHVTSTLFMPFMNKEFKEKIFTHDGRHLSKLREMVGYESLPAEYGGP---------A 239
            |.:.:.:.:|...||..||:..:.:::||.| |.:|:.|.:::..|.||:|:||.         |
Human   221 HFVNQPWYIHALYTLIKPFLKDKTRKRIFLH-GNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWA 284

  Fly   240 TNVL-----DTNLIFNHLSQNAEYLE 260
            ..:|     |.| .:.|.|.||.:::
Human   285 RTLLGPDYSDEN-DYTHTSYNAMHVK 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31826	NP_001260473.1	CRAL_TRIO_N	17..61	CDD:215024	9/43 (21%)
CG31826	NP_001260473.1	CRAL_TRIO	92..237	CDD:279044	39/150 (26%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	9/43 (21%)
		CRAL_TRIO	125..274	CDD:306996	42/160 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810