DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31826 and CLVS2

DIOPT Version :9

Sequence 1:	NP_001260473.1	Gene:	CG31826 / 326164	FlyBaseID:	FBgn0051826	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001010852.2	Gene:	CLVS2 / 134829	HGNCID:	23046	Length:	327	Species:	Homo sapiens

Alignment Length:	250	Identity:	52/250 - (20%)
Similarity:	114/250 - (45%)	Gaps:	59/250 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IEQLRQLVEKCEDLR-VGTEDTLLTKFLHYTRWDTIKAYQAIHDYYEFKRRH----PTWVARHP- 76
            |:::|.:|....|:. :.|:|..:.:||...::...:|::.:..|:|:::::    .::.|..|
Human    31 IQEVRDMVITRPDIGFLRTDDAFILRFLRARKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPG 95

  Fly    77 ---------------IEHYRQLFYGTHCRYVMPQADRSGRVLVVFKTVDGFQDYPDYLQSLVEMD 126
                           ::||.:                  ::||:|..        ::.||...:.
Human    96 IKQALKDGFPGGLANLDHYGR------------------KILVLFAA--------NWDQSRYTLV 134

  Fly   127 DLIFESLLLL------PRVQQNGITVICDLQGTNRNFLRQFSPAFMKVVNEKNGVL-PFSQRI-- 182
            |::...||.|      |.:|.||..:|.|..........:.:|:.:::..|  |:. .|..|.
Human   135 DILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSMLRLAIE--GLQDSFPARFGG 197

  Fly   183 VHIIQRGFLMHVTSTLFMPFMNKEFKEKIFTHDGRHLSKLREMVGYESLPAEYGG 237
            :|.:.:.:.:|...|:..||:.::.:::||.| |.:|:.|.:::..|.||:|:||
Human   198 IHFVNQPWYIHALYTVIRPFLKEKTRKRIFLH-GNNLNSLHQLIHPEILPSEFGG 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31826	NP_001260473.1	CRAL_TRIO_N	17..61	CDD:215024	9/43 (21%)
CG31826	NP_001260473.1	CRAL_TRIO	92..237	CDD:279044	35/153 (23%)
CLVS2	NP_001010852.2	CRAL_TRIO_N	29..75	CDD:215024	9/43 (21%)
		SEC14	106..251	CDD:238099	37/173 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810