DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31823 and CTSA

DIOPT Version :9

Sequence 1:	NP_723939.1	Gene:	CG31823 / 326163	FlyBaseID:	FBgn0051823	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001161066.1	Gene:	CTSA / 5476	HGNCID:	9251	Length:	481	Species:	Homo sapiens

Alignment Length:	456	Identity:	100/456 - (21%)
Similarity:	179/456 - (39%)	Gaps:	105/456 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VQGRVGLG--PGVQEWD-YVEVRKGAHLFYWLLYTTANVSHFIERPLVIWLQGGPGVASTGSGIF 85
            :|...||.  |..:::. |::.....||.||.:.:..:..:   .|:|:||.||||.:|. .|:.
Human    53 IQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPEN---SPVVLWLNGGPGCSSL-DGLL 113

  Fly    86 EQLGPIDIEGKTRESSWLKHVNVLFVDSPVGTGFAYVEHHSLYARNNRQIALDLVQLMKQFLTKY 150
            .:.||..|            .|||:::||.|.||:|.: ...||.|:.::|....:.::.|...:
Human   114 TEHGPFLI------------ANVLYLESPAGVGFSYSD-DKFYATNDTEVAQSNFEALQDFFRLF 165

  Fly   151 PDFRKVPLHIFSESYGGKMAPEFALELHLAKKVGELECDLKSVVVGNPWTSPLDSILSYAPFLLQ 215
            |:::...|.:..|||.|...|..|:.:     :.:...:|:.:.|||..:|...:..|...|...
Human   166 PEYKNNKLFLTGESYAGIYIPTLAVLV-----MQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYY 225

  Fly   216 SGIVDD---------------------------DGYRRISRLAGELAALVY-------GG--KWL 244
            .|::.:                           ...:.::|:.|.....:|       ||  ...
Human   226 HGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHF 290

  Fly   245 RALMKATEVQDEISASAGGVFIYNTQRRVHVDEVYRYGE----DPQMSDFMRSN-------VTKA 298
            |.......|||     .|.:|.....:|:....:.|.|:    ||..::...::       |.||
Human   291 RYEKDTVVVQD-----LGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKA 350

  Fly   299 LGL-GNMPVWMEQNSTV---FERLSQDIFKPANQIVTKLLEETPIQVGIYSGILDLLCATPGTVN 359
            |.: ..:|.|...|..|   :.||    ::..|....|||.....|:.:|:|.:|:.|...|. .
Human   351 LNIPEQLPQWDMCNFLVNLQYRRL----YRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGD-E 410

  Fly   360 W----------IRRLKWRRSLEYAKAPRTAIRIEGMLEGYEKHGGKLSMFWVFRAGHLVQQENPA 414
            |          ::|..|  .::|..:..       .:.|:.|....::...:..|||:|..:.|.
Human   411 WFVDSLNQKMEVQRRPW--LVKYGDSGE-------QIAGFVKEFSHIAFLTIKGAGHMVPTDKPL 466

  Fly   415 A 415
            |
Human   467 A 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31823	NP_723939.1	Peptidase_S10	26..425	CDD:298660	99/454 (22%)
CTSA	NP_001161066.1	Peptidase_S10	57..477	CDD:278857	99/452 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810