DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31823 and Ctsa

DIOPT Version :9

Sequence 1:	NP_723939.1	Gene:	CG31823 / 326163	FlyBaseID:	FBgn0051823	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_032932.2	Gene:	Ctsa / 19025	MGIID:	97748	Length:	492	Species:	Mus musculus

Alignment Length:	465	Identity:	106/465 - (22%)
Similarity:	187/465 - (40%)	Gaps:	108/465 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CVQGRVGLGPGVQEWD-YVEVRKGAHLFYWLLYTTANVSHFIE-------RPLVIWLQGGPGVAS 79
            |:.| :...|..:::. |:......|..||          |:|       .|:|:||.||||.:|
Mouse    50 CLPG-LAKQPSFRQYSGYLRASDSKHFHYW----------FVESQNDPKNSPVVLWLNGGPGCSS 103

  Fly    80 TGSGIFEQLGP--IDIEGKTRE---SSWLKHVNVLFVDSPVGTGFAYVEHHSLYARNNRQIALDL 139
            . .|:..:.||  |..:|.|.|   .:|....|||:::||.|.||:|.: ..:|..|:.::|.:.
Mouse   104 L-DGLLTEHGPFLIQPDGVTLEYNPYAWNLIANVLYIESPAGVGFSYSD-DKMYVTNDTEVAENN 166

  Fly   140 VQLMKQFLTKYPDFRKVPLHIFSESYGGKMAPEFALELHLAKKVGELECDLKSVVVGNPWTSPLD 204
            .:.:|.|...:|:::...|.:..|||.|...|..|:.:     :.:...:|:.:.|||...|...
Mouse   167 YEALKDFFRLFPEYKDNKLFLTGESYAGIYIPTLAVLV-----MQDPSMNLQGLAVGNGLASYEQ 226

  Fly   205 SILSYAPFLLQSGIVDD---------------------------DGYRRISRLAGELAALVY--- 239
            :..|...|....|::.:                           :....:||:.|:....:|
Mouse   227 NDNSLVYFAYYHGLLGNRLWTSLQTHCCAQNKCNFYDNKDPECVNNLLEVSRIVGKSGLNIYNLY 291

  Fly   240 ----GGKWLRALMKATEVQDEISASAGGVFIYNTQRRVHVDEVYRYGE----DPQM------SDF 290
                ||...|...:.|.|..:.    |.:|.....:|...:.:.|.|:    ||..      |::
Mouse   292 APCAGGVPGRHRYEDTLVVQDF----GNIFTRLPLKRRFPEALMRSGDKVRLDPPCTNTTAPSNY 352

  Fly   291 MRS-NVTKALGL-GNMPVWMEQNSTV---FERLSQDIFKPANQIVTKLLEETPIQVGIYSGILDL 350
            :.: .|.|||.: .::|.|...|..|   :.||.|.:    |....|||.....|:.:|:|.:|:
Mouse   353 LNNPYVRKALHIPESLPRWDMCNFLVNLQYRRLYQSM----NSQYLKLLSSQKYQILLYNGDVDM 413

  Fly   351 LCATPGTVNW----------IRRLKWRRSLEYAKAPRTAIRIEGMLEGYEKHGGKLSMFWVFRAG 405
            .|...|. .|          ::|..|  .::|.::..       .:.|:.|....::...:..||
Mouse   414 ACNFMGD-EWFVDSLNQKMEVQRRPW--LVDYGESGE-------QVAGFVKECSHITFLTIKGAG 468

  Fly   406 HLVQQENPAA 415
            |:|..:.|.|
Mouse   469 HMVPTDKPRA 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31823	NP_723939.1	Peptidase_S10	26..425	CDD:298660	105/462 (23%)
Ctsa	NP_032932.2	Peptidase_S10	52..488	CDD:366108	105/463 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710