DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31823 and ctsa-2

DIOPT Version :9

Sequence 1:	NP_723939.1	Gene:	CG31823 / 326163	FlyBaseID:	FBgn0051823	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_509079.2	Gene:	ctsa-2 / 180915	WormBaseID:	WBGene00019617	Length:	2314	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	117/498 - (23%)
Similarity:	189/498 - (37%)	Gaps:	134/498 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PGV-------QEWDYVEVRKGAHLFYWLLYTTANVSHFIER-------PLVIWLQGGPGVASTGS 82
            |||       |...|::..:|..||||          |:|.       |:::|||||||.||||
Worm  1672 PGVTWNVNFMQHSGYLQATRGNKLFYW----------FVESQSGNEGDPIILWLQGGPGCASTG- 1725

  Fly    83 GIFEQLGP--IDIEGKT---RESSWLKHVNVLFVDSPVGTGFAY----VEHHSLYARNNRQIALD 138
            |:|.::||  ::.:|:|   ...||.|..::|.:|||.|.||:|    |.:.:.:  ::.:.|||
Worm  1726 GLFSEIGPFFVNPDGETLFENIYSWNKAAHILIIDSPRGVGFSYQDKNVNNDTTW--DDDKTALD 1788

  Fly   139 LVQLMKQFLTKYPDFRKVPLHIFSESYGGKMAPEFALELHLAKKVGELECDLKSVVVGNPWTSPL 203
            ....::.|...||..|...|:|..|||||...|.....|....:.|:....|:.:.:||...|.:
Worm  1789 TYTALEDFFVTYPPHRNSELYITGESYGGVYVPTLTRLLIQKIQAGQSNIQLRGMGIGNGMVSAV 1853

  Fly   204 DSILSYAPFLLQSGIVD----------------------------DDGYRRISR----------L 230
            :.:.:...||...||.|                            |.|...|::          .
Worm  1854 NDVRTLPDFLYFHGIYDKPMWEKLRACCPSADSSGDCNYDYYITIDSGVNVIAKQFPNNQTLQDC 1918

  Fly   231 AGELAALVYGGKWLRALMKATEVQDEISASAGGVFIYNTQR-------------RVHVDEVYRYG 282
            |..:..|.|...|.....:....||          .|.|.|             |:.||...:..
Worm  1919 ANLVENLSYDRNWKALYDQYNLYQD----------CYVTPRDQANPFAMKEKFSRLDVDHKLKTS 1973

  Fly   283 ----------EDPQMSD----------------FMRSNVTKALGL-GNMPVWMEQNSTVFERLSQ 320
                      :||..:|                ...|:|..||.: .::|.|...|...:..|..
Worm  1974 IPQAITKTAPQDPLSTDATGGYSCWSLGAINNYLSLSHVRDALHIPDSVPRWGFCNKINYANLYN 2038

  Fly   321 DIFKPANQIVTKLLEE-TPIQVGIYSGILDLLCATPGTVNWIRRLKWRRSLEYAKAPRTAIRIEG 384
            |    ..|:.|.:|.. ..::|.||:|.:|.:|:.....:.|......::. .:..||.:....|
Worm  2039 D----TTQVFTDILNSGYNLKVLIYNGDVDSVCSMFEAESMINNFAAAQTF-VSNQPRGSWMYGG 2098

  Fly   385 MLEGY----EKHGGKLSMFWVFRAGHLVQQENPAAMAYILRYF 423
            .:.||    :|:...:.:..|..|||:...:.|..:..::..|
Worm  2099 QIGGYVQKFQKNNMTIDLLTVKGAGHMSPTDRPGPVLQMMNNF 2141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31823	NP_723939.1	Peptidase_S10	26..425	CDD:298660	117/498 (23%)
ctsa-2	NP_509079.2	Peptidase_S10	33..537	CDD:278857
		Peptidase_S10	581..1047	CDD:278857
		Peptidase_S10	1139..1633	CDD:278857
		Peptidase_S10	1672..2144	CDD:278857	117/498 (23%)
		E_Pc_C	<2193..2301	CDD:284226
		DUF3432	2195..2291	CDD:288743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710