Protein Alignment CG31793 and ABCC12

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_150229.2
• Gene: ABCC12 / 94160
• HGNCID: 14640
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1373
• Identity: 437/1373 - (31%)
• Similarity: 741/1373 - (53%)
• Gaps: 158/1373 - (11%)

  Fly     4 SKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVA 67
            ::|.|||.:.||:||...|.:..|::.||.:|.| ..|....|:.::::....:.|:. |::|||
Human    39 ARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRL-TVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102

  Fly    68 RCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYN 132
            |.     ...|.|:..|:.:....|::|. |....|.:...|..|::|...|.:.:|..:|
Human   103 RV-----GPEKASLSHVVWKFQRTRVLMD-IVANILCIIMAAIGPVILIHQILQQTERTSG---- 157

  Fly   133 AQIYAVLLIACILASVLLTHPYMMGM-----MHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQ 192
             :::..:.:...|.:...|..:...:     ...|::::||:|:.::...  :|..:|...:.|:
Human   158 -KVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL--VSFKTLTHISVGE 219

  Fly   193 VVNLLSND-LNRFDRCLIHFHFLWLG---PLELLIASYFLYEQIGMASFYGISILVLYLPLQTYL 253
            |:|:||:| .:.|:..|    |..|.   |:.::..:.:.:..:|..:..|||:.|:::|:|.::
Human   220 VLNILSSDSYSLFEAAL----FCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFM 280

  Fly   254 SRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGI 318
            :::.|..|....|.||:||:.|||.::.|::||||.||:.|...|..:||.|...:.:...::..
Human   281 AKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSG 345

  Fly   319 LLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMR 383
            ..:....:..|||.::|...:|...:|||..||.|.|.:|:::.::: ..|..:...||..||:|
Human   346 NSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA-ILPFSIKAMAEANVSLR 409

  Fly   384 RITNFMM-REEANVIDMSERRD-----------------------EKAEEEQHLLKEVEKRSYPV 424
            |:...:: :...:.|...|..|                       :...:::||.|:....:|.
Human   410 RMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYS- 473

  Fly   425 GIGKEPDTLVEIKALRARWGQEQHD---LVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGEL 486
              .:.|      .|..|...:||.|   .||::::..:|:|:::.:.|.||||||||:.|:||::
Human   474 --ERSP------PAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQM 530

  Fly   487 PPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTI 550
            ..:.|.|.|:|..:|.||:.|:|:.:||:|||||...|.|||:..::.|.|::|| .|.:||.|.
Human   531 QLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595

  Fly   551 VGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTH 615
            :||||.:||||||.||.||||||....:|||||||||||.|||:|:|:||::..|..:.|:||||
Human   596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660

  Fly   616 QLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQL-------------------LVESTQNS 661
            ||||||..|.:::::.|.:...||::|:::....:|:|                   :||:.:.|
Human   661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKES 725

  Fly   662 GGGDE-----IITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSM 721
            ....|     |:.:|.        :.|.....|.:....|:.:.|:...:.: ||...|.:....
Human   726 PAEREEDAGIIVLAPG--------NEKDEGKESETGSEFVDTKVPEHQLIQT-ESPQEGTVTWKT 781

  Fly   722 YKKYFGAGCGVLV---FVVLIMLCIGTQILASGGDYFLSYWVKNTASSST--------------- 768
            |..|..|..|.|:   .|.|.:|.||:   |:..:::|..|: :..|..|
Human   782 YHTYIKASGGYLLSLFTVFLFLLMIGS---AAFSNWWLGLWL-DKGSRMTCGPQGNRTMCEVGAV 842

  Fly   769 -LDI------YYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGR 826
             .||      :.:||..|.:::..:.:..:|...|:.:|:.||:|:|..:.::.:.||.|.|:||
Human   843 LADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGR 907

  Fly   827 ILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKT 891
            ::|||:.|:.::|..:|....:.:|.|..:..|:.:|....|..|:...::.:.|:.....:.:.
Human   908 LMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRG 972

  Fly   892 SRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGY 956
            .:::|::|.|:|||.::|.::::.||..|.|.|.:::.|    .|..|:      |....|.|..
Human   973 VQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCI----TYHLLY------FNCALRWFAL 1027

  Fly   957 YLDL------FCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTS 1015
            .:|:      |.||.::::...:.      :....||:::..:.::|::|..:|...|.:...||
Human  1028 RMDVLMNILTFTVALLVTLSFSSI------STSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTS 1086

  Fly  1016 VERVLEY-KDLDPEGDFNSPAEKQP-PKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPM 1078
            ||.:.|| ....||  ...|.:... ||.||..|::..:|..:||.  .|:|.||..|:..||..
Human  1087 VELLREYISTCVPE--CTHPLKVGTCPKDWPSRGEITFRDYQMRYR--DNTPLVLDSLNLNIQSG 1147

  Fly  1079 EKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMR 1142
            :.||||||||:|||||..||||| ....|.|.||.:|...:.|.|||:|:::|||:||||.||:|
Human  1148 QTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212

  Fly  1143 YNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRI 1207
            |||||||.:.|:.||:.||...:::.|.:||..||:.::|.|.|||||:|||:|:|||:||.::|
Human  1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKI 1277

  Fly  1208 LVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            :::|||||::|.:||.|:|.||::.||.||||||||||||:::.|.||||:.|.|:||..| |:|
Human  1278 ILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVL 1341

  Fly  1273 TASKAKVF 1280
            .......|
Human  1342 AEKPDSAF 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	434/1367 (32%)
ABCC12	NP_150229.2	MRP_assoc_pro	43..1344	CDD:188098	435/1362 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..491		9/53 (17%)