DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC12

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1373	Identity:	437/1373 - (31%)
Similarity:	740/1373 - (53%)	Gaps:	158/1373 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVA 67
            ::|.|||.:.||:||...|.:..|::.||.:|.| ..|....|:.::::....:.|:. |::|||
Human    39 ARLAPNPVDDAGLLSFATFSWLTPVMVKGYRQRL-TVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102

  Fly    68 RCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYN 132
            |.     ...|.|:..|:.:....|::|. |....|.:...|..|.:|...|.:.:|..:|
Human   103 RV-----GPEKASLSHVVWKFQRTRVLMD-IVANILCIIMAAIGPTVLIHQILQQTERTSG---- 157

  Fly   133 AQIYAVLLIACILASVLLTHPYMMGM-----MHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQ 192
             :::..:.:...|.:...|..:...:     ...|::::||:|:.::...  :|..:|...:.|:
Human   158 -KVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENL--VSFKTLTHISVGE 219

  Fly   193 VVNLLSND-LNRFDRCLIHFHFLWLG---PLELLIASYFLYEQIGMASFYGISILVLYLPLQTYL 253
            |:|:||:| .:.|:..|    |..|.   |:.::..:.:.:..:|..:..|||:.|:::|:|.::
Human   220 VLNILSSDSYSLFEAAL----FCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFM 280

  Fly   254 SRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGI 318
            :::.|..|....|.||:||:.|||.::.|::||||.||:.|...|..:||.|...:.:...::..
Human   281 AKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSG 345

  Fly   319 LLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMR 383
            ..:....:..|||.::|...:|...:|||..||.|.|.:|:::.::: ..|..:...||..||:|
Human   346 NSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSIA-ILPFSIKAMAEANVSLR 409

  Fly   384 RITNFMM-REEANVIDMSERRD-----------------------EKAEEEQHLLKEVEKRSYPV 424
            |:...:: :...:.|...|..|                       :...:::||.|:....:|.
Human   410 RMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYS- 473

  Fly   425 GIGKEPDTLVEIKALRARWGQEQHD---LVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGEL 486
              .:.|      .|..|...:||.|   .||::::..:|:|:::.:.|.||||||||:.|:||::
Human   474 --ERSP------PAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQM 530

  Fly   487 PPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTI 550
            ..:.|.|.|:|..:|.||:.|:|:.:||:|||||...|.|||:..::.|.|::|| .|.:||.|.
Human   531 QLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTE 595

  Fly   551 VGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTH 615
            :||||.:||||||.||.||||||....:|||||||||||.|||:|:|:||::..|..:.|:||||
Human   596 IGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660

  Fly   616 QLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQL-------------------LVESTQNS 661
            ||||||..|.:::::.|.:...||::|:::....:|:|                   :||:.:.|
Human   661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKES 725

  Fly   662 GGGDE-----IITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSM 721
            ....|     |:.:|.        :.|.....|.:....|:.:.|:...:.: ||...|.:....
Human   726 PAEREEDAGIIVLAPG--------NEKDEGKESETGSEFVDTKVPEHQLIQT-ESPQEGTVTWKT 781

  Fly   722 YKKYFGAGCGVLV---FVVLIMLCIGTQILASGGDYFLSYWVKNTASSST--------------- 768
            |..|..|..|.|:   .|.|.:|.||:   |:..:::|..|: :..|..|
Human   782 YHTYIKASGGYLLSLFTVFLFLLMIGS---AAFSNWWLGLWL-DKGSRMTCGPQGNRTMCEVGAV 842

  Fly   769 -LDI------YYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGR 826
             .||      :.:||..|.:::..:.:..:|...|:.:|:.||:|:|..:.::.:.||.|.|:||
Human   843 LADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGR 907

  Fly   827 ILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKT 891
            ::|||:.|:.::|..:|....:.:|.|..:..|:.:|....|..|:...::.:.|:.....:.:.
Human   908 LMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRG 972

  Fly   892 SRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGY 956
            .:::|::|.|:|||.::|.::::.||..|.|.|.:::.|    .|..|:      |....|.|..
Human   973 VQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCI----TYHLLY------FNCALRWFAL 1027

  Fly   957 YLDL------FCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTS 1015
            .:|:      |.||.::::...:.      :....||:::..:.::|::|..:|...|.:...||
Human  1028 RMDVLMNILTFTVALLVTLSFSSI------STSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTS 1086

  Fly  1016 VERVLEY-KDLDPEGDFNSPAEKQP-PKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPM 1078
            ||.:.|| ....||  ...|.:... ||.||..|::..:|..:||.  .|:|.||..|:..||..
Human  1087 VELLREYISTCVPE--CTHPLKVGTCPKDWPSRGEITFRDYQMRYR--DNTPLVLDSLNLNIQSG 1147

  Fly  1079 EKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMR 1142
            :.||||||||:|||||..||||| ....|.|.||.:|...:.|.|||:|:::|||:||||.||:|
Human  1148 QTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVR 1212

  Fly  1143 YNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRI 1207
            |||||||.:.|:.||:.||...:::.|.:||..||:.::|.|.|||||:|||:|:|||:||.::|
Human  1213 YNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKI 1277

  Fly  1208 LVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            :::|||||::|.:||.|:|.||::.||.||||||||||||:::.|.||||:.|.|:||..| |:|
Human  1278 ILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKP-EVL 1341

  Fly  1273 TASKAKVF 1280
            .......|
Human  1342 AEKPDSAF 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	435/1364 (32%)
		ABC_membrane	112..364	CDD:294371	66/260 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	98/201 (49%)
		ABC_membrane	736..955	CDD:294371	58/240 (24%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	118/221 (53%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		9/53 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820