Protein Alignment CG31793 and ABCC3

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_003777.2
• Gene: ABCC3 / 8714
• HGNCID: 54
• Length: 1527
• Species: Homo sapiens
• Alignment Length: 1383
• Identity: 478/1383 - (34%)
• Similarity: 723/1383 - (52%)
• Gaps: 149/1383 - (10%)

  Fly     3 ASKLPPN--PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGW--- 62
            |..:.||  |..|||.||.|.|.:...:...|.:..|:..||:....|..:..:..:..:.|
Human   199 AKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ 263

  Fly    63 EDEVARCRR-----KGDSG------------RKPSVLRVIGRVFGWRLIMSGITIAALELGTRAT 110
            |.:.||.:.     |..||            ||||.|:.:...||...::|.......:|.:...
Human   264 EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFIN 328

  Fly   111 VPLLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYR 175
             |.||:.|| .|..:....|:...:.|.|:..|.:...|:...|...:....:|.|..:...|||
Human   329 -PQLLSILI-RFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYR 391

  Fly   176 KALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGI 240
            |||.::.:....:|.|::|||:|.|..||.......:.||..||::::|.|||::.:|.:...|:
Human   392 KALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGV 456

  Fly   241 SILVLYLPLQTYLSRVTSKLRL----QTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQM 301
            :.:||.:||.   ..|..|:|.    |..|: |.|:::|:||::||:|:|:|.||..|.|.:..:
Human   457 AFMVLLIPLN---GAVAVKMRAFQVKQMKLK-DSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGI 517

  Fly   302 RRSEMSSIRQMNLLR------GILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNIL 360
            |:.|:..:|....|.      .:...|.:||..:.::|    :|.....|.||:||...:.:|||
Human   518 RQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV----YVDPNNVLDAEKAFVSVSLFNIL 578

  Fly   361 RRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVG 425
            |..:: ..|..:|...:..||::||..|:.:||.:.                  :.||:::.
Human   579 RLPLN-MLPQLISNLTQASVSLKRIQQFLSQEELDP------------------QSVERKTI--- 621

  Fly   426 IGKEPDTLVEIKALRARWGQEQHDL--VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPP 488
               .|...:.|.:....|.|   ||  .|:::::.:.:|.||||:||||.|||||:.|:|||:..
Human   622 ---SPGYAITIHSGTFTWAQ---DLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEK 680

  Fly   489 ESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVG 552
            ..|.|.:.|..:|..|:.|:.|.::::|:|||..::.:||:..|:.|||..|||:| .||.|.:|
Human   681 LEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIG 745

  Fly   553 ERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTH 615
            |:|.:||||||.|:.||||||..||::||||||||||:||.:|:||..:  .|.|..:..:||||
Human   746 EKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTH 810

  Fly   616 QLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQ---------------------------- 652
            .:.||...|.|:::..|.||..|.|..:|:....||.
Human   811 GISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKE 875

  Fly   653 -LLVESTQNS----GGGDEI--ITSPNLSRQSSALSTKSSNGSSSS----------LESMVEKEK 700
             ||:|.|.::    ...|.:  :......||.|||   ||:|....          .|.:...|.
Human   876 ALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSAL---SSDGEGQGRPVPRRHLGPSEKVQVTEA 937

  Fly   701 PKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTAS 765
            ....|::.:|..:.|.:.||::..|..| .|:...:.:.:|.:|....|.|.:.:||.|..:..:
Human   938 KADGALTQEEKAAIGTVELSVFWDYAKA-VGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMA 1001

  Fly   766 SS-------TLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNP 823
            .|       .|.:|....|..|.::  :|..:......:.::..||..:.....|:...||.|.|
Human  1002 DSRQNNTSLRLGVYAALGILQGFLV--MLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTP 1064

  Fly   824 SGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFY 888
            ||||||.|:.|:..||||:..|:|..:..|......:.|:..:.|.:.:....:.:.:...:.||
Human  1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFY 1129

  Fly   889 LKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRA 953
            ..|||.:||||:|:|||:|||||.|:.|...|||....:......|...|.:....|.::.::|.
Human  1130 AATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRW 1194

  Fly   954 FGYYLDLF--CV---AYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAM 1013
            ....::..  ||   |.:.:||..:..||     |.:||:::.:|.:|..:.|.:|..::||:.:
Human  1195 LSIGVEFVGNCVVLFAALFAVIGRSSLNP-----GLVGLSVSYSLQVTFALNWMIRMMSDLESNI 1254

  Fly  1014 TSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPM 1078
            .:||||.||...:.|..:.....: ||:.||..|::..::.|:||.|..:  .||:.||..:...
Human  1255 VAVERVKEYSKTETEAPWVVEGSR-PPEGWPPRGEVEFRNYSVRYRPGLD--LVLRDLSLHVHGG 1316

  Fly  1079 EKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMR 1142
            |||||||||||||||:...||| |....|.|.||.|:..|||||||||:::||||:|:|||||:|
Human  1317 EKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLR 1381

  Fly  1143 YNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRI 1207
            .|||||..|.::.:|.|||..||...:|..|:||....||||.|.|||||||||||||:||::||
Human  1382 MNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446

  Fly  1208 LVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            ||:|||||.:|.:||.|||||||.:|..|||||||||||||||..:|||:|.|.|.||.||..|:
Human  1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLI 1511

  Fly  1273 TASKAKVFHGMVMQTGKA 1290
            .|  ..:|:||....|.|
Human  1512 AA--RGIFYGMARDAGLA 1527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	475/1374 (35%)
ABCC3	NP_003777.2	MRP_assoc_pro	7..1526	CDD:188098	476/1380 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	910..932		5/24 (21%)