DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31793 and YKR104W

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	313	Identity:	137/313 - (43%)
Similarity:	198/313 - (63%)	Gaps:	29/313 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1013 MTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQP 1077
            |:||||:.||.|:..|    |.....||.:||:.|.:..|:|||||.|  :|...|..:||.::.
Yeast     1 MSSVERIKEYTDIPSE----SNGYISPPANWPQTGDVELKNLSLRYSP--HSSKALDNVSFKVKA 59

  Fly  1078 MEKVGIVGRTGAGKSSLINALFRLS-YNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTM 1141
            ..||||||||||||||:|.|::||| :.:|.|.||:.|...|.|..||:.||.|||:|.||.||:
Yeast    60 GTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTV 124

  Fly  1142 RYNLDPFEQYPDDKLWKALEDVHLKEEISEL--------PS-----------GLQSIISEGGTNF 1187
            |.|||||::|.|.:::..|..|.|.||..||        |:           .|.:::..||:|.
Yeast   125 RSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNL 189

  Fly  1188 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSD 1252
            |.|||||:||||::|....|:::|||||::|..:||.||.|||...|:.|:|||||||.:::|.|
Yeast   190 SQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYD 254

  Fly  1253 KVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENTKQN 1305
            |:|||:.|.|.|:..||.|: :.:..:|:.:..|:|:  |::|.::|:.:..|
Yeast   255 KILVMEMGRVKEYDHPYTLI-SDRNTIFYRLCRQSGE--FENLFELAKVSFDN 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	130/279 (47%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217
		ABC_membrane	736..955	CDD:294371
		ABCC_MRP_domain2	1047..1268	CDD:213211	113/240 (47%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	115/244 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900