DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and NFT1

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1055	Identity:	274/1055 - (25%)
Similarity:	469/1055 - (44%)	Gaps:	183/1055 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYK-TLNEHEAASLGDEFFQGWEDEVAR 68
            ||||.|.    :...|.|.....:::|..|..|...|::. .:|....|.|            |.
Yeast   241 KLPPAPT----VFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAIL------------AN 289

  Fly    69 CRRKGDSGR-KPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYN 132
            .......|| .|:::.....||..:|.::.:: :.|..     ||.||...|..:.......|:|
Yeast   290 FEMSSKKGRLLPNIICYFKAVFISQLFLAFVS-SFLNF-----VPSLLMPRILSYVNDPKSKSWN 348

  Fly   133 -AQIY-AVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTT----- 190
             ..:| :.:|::.|:|:........:|... .|::|..:.|.||.|.||  ||.|..:||
Yeast   349 LVSLYVSSMLVSKIIATTCRGQGLFLGEKG-TMQLRTVLISNIYSKTLR--RTILKDSTTSLQKN 410

  Fly   191 ------------------------GQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQ 231
                                    ..|.|::|.|..:....:..|:.........:.|...||..
Yeast   411 ASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSL 475

  Fly   232 IGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGK 296
            :|.::|.|...|:..:||..:.:......:....:.||:|...::|.::.|:|||:..||..|.:
Yeast   476 LGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQ 540

  Fly   297 LIGQMRRSEMSSIRQ---MNLLRGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYN 358
            .|..:|..|:..:::   :..|..::..|..||.....|...:.|  ....||...||...:.:.
Yeast   541 KIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKF--QNQTLTPTIAFTALSLFA 603

  Fly   359 ILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYP 423
            |||..:.: ..|.:|...:..:|:.||.:::...|....::.|:.:.|
Yeast   604 ILRTPMDQ-IASTVSLLIQSFISLERIQDYLNESETRKYEILEQSNTK----------------- 650

  Fly   424 VGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPP 488
              .|.| |..:|       |...:....|.|:::..:...|.|:|||.|||||||:..:||||..
Yeast   651 --FGFE-DASME-------WEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNL 705

  Fly   489 ESGSVQV----------------SGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCAL 537
            .||.:.|                :...:|.||.|||.:.:::||::||...:||::..|:|.|.|
Yeast   706 LSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCL 770

  Fly   538 ERDLE-LLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM 601
            ::|:: :..|..|.||:.|.||||||:.||.||||:|..:...:|||.|||||.....::::||:
Yeast   771 DKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECL 835

  Fly   602 RGFLGK-QLVILVTHQLQFL-EDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGG 664
            .|.:.| :..|:.:|.:..: :.||.:||:|:|.|.:.|...:::||.    :.|.||..|
Yeast   836 CGPMMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKSN----EFLRESINN---- 892

  Fly   665 DEIITSPN---LSRQSSALSTKSSN--GSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYK- 723
            |...|:.|   |.|.:::..||:.:  |.:|..|...|.|       :.:|::..|.:..|.||
Yeast   893 DSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVE-------NFEETKMEGSVKFSAYKW 950

  Fly   724 --KYFGAGCGVL-VFVVLIMLCIGTQILASGGDYFLSYWVKNTASSST-----------LDIYY- 773
              .||| |.||: ||....:|..|  |..|.| ::|.||:...:|.|.           .:||:
Yeast   951 LADYFG-GLGVVFVFTSSSILIHG--ITLSQG-FWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFL 1011

  Fly   774 FTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALY----FFHTNPSGRILNRFAND 834
            .|.|.:|||...|....::  |.:.|.|.:...:|..|..:.||    |.:..|:|||:|||:.|
Yeast  1012 LTYIIIGLVSSFLTSGKVW--IAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKD 1074

  Fly   835 LGQVDEVMPAVMLDCIQIF--LTLTGIICVLCV-----TNPWYLINTFAMMLAFYYWRDFYLKTS 892
            :..:|:.:       |..|  |:.:.::|:..:     ..|.:|:....:...:|.....||:.|
Yeast  1075 MDIIDQQL-------IPNFEGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTLYLRAS 1132

  Fly   893 RDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYY 957
            |::||::.:..||::..|:..:.|:.||||:..::..|.|           ....:..|.|..:|
Yeast  1133 RELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQ-----------SLVAIDRSNAPFFY 1186

  Fly   958 LDLFC--VAYVISVI 970
            |::..  :.|.:.:|
Yeast  1187 LNMATEWITYRVDII 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	274/1055 (26%)
		ABC_membrane	112..364	CDD:294371	65/285 (23%)
		ABCC_MRP_domain1	434..632	CDD:213217	77/216 (36%)
		ABC_membrane	736..955	CDD:294371	60/241 (25%)
		ABCC_MRP_domain2	1047..1268	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	269/1040 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900