DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC11

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1388	Identity:	461/1388 - (33%)
Similarity:	721/1388 - (51%)	Gaps:	192/1388 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLG-DEFFQGWEDEVARCRR 71
            |.|.::||:.|.|...:..|::.:..:..|....: ..|:.|:|:... ....:.||:||:   |
Human    83 PQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTI-PPLSVHDASDKNVQRLHRLWEEEVS---R 143

  Fly    72 KGDSGRKPSVLRVIGRVFGWRLIMSGI-----TIAALELGTRATVPLLLAGLISEFSE------- 124
            :|.  .|.|||.|:.|....|||...:     .||:: ||     |:|:...|.|:||
Human   144 RGI--EKASVLLVMLRFQRTRLIFDALLGICFCIASV-LG-----PILIIPKILEYSEEQLGNVV 200

  Fly   125 HGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTT 189
            ||.|     ..:|:.|..|: .|:..:..:::. ...|::.|.||||..:.|.::..  |:...|
Human   201 HGVG-----LCFALFLSECV-KSLSFSSSWIIN-QRTAIRFRAAVSSFAFEKLIQFK--SVIHIT 256

  Fly   190 TGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELL---------IASYFLYEQIGMASFYGISILVL 245
            :|:.::..:.|:|..      |..:..|||.|:         |:|||:   ||..:|..|...:|
Human   257 SGEAISFFTGDVNYL------FEGVCYGPLVLITCASLVICSISSYFI---IGYTAFIAILCYLL 312

  Fly   246 YLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIR 310
            ..||..:::|:..|.:..|:..:|||:|:.:|:::.|::|||||||:||.|:|..:||.|...:.
Human   313 VFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLE 377

  Fly   311 QMNLLRGILLSFEITLGRIAIFVSLLGFVLGGG---ELTAERAFCVTAFYNILRRTVSKFFPSGM 372
            :..|::.:.   .|||..|....:.:..::...   :|||..||.:.|..|:||.:|. |.|..:
Human   378 KCGLVQSLT---SITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVF-FVPIAV 438

  Fly   373 SQFAELLVSMRRITNFMMREEANVIDMSERRD-------EKA------------------EEEQH 412
            ........::.|...|.: :|:.|..:...:|       |:|                  |...|
Human   439 KGLTNSKSAVMRFKKFFL-QESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGH 502

  Fly   413 LLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSS 477
            ..:.:.:....:|..:|.::|          |.|.|     .:|:.:.:|.::.|.|..||||||
Human   503 ASEGMTRPRDALGPEEEGNSL----------GPELH-----KINLVVSKGMMLGVCGNTGSGKSS 552

  Fly   478 LIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLE 542
            |:.|||.|:....|||.|.|..:|..|:.|:.:.::|:|||.|...||.||..||..|:|.||||
Human   553 LLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

  Fly   543 LL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLG 606
            || .||.|.:||||.:|||||:.||.||||||....:|||||||||||.|||:|:|:||::..|.
Human   618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR 682

  Fly   607 KQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGD------ 665
            .:.|:|||||||:||....|::::.|.:...||:.|:::....:|| |::........|
Human   683 GKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQ-LIQKMHKEATSDMLQDTA 746

  Fly   666 EIITSPNLSRQSSALSTKSS-NGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAG 729
            :|...|.:..|:.|.|.:.| ||::.::..         ..::.:|....|.:...:|..|..|.
Human   747 KIAEKPKVESQALATSLEESLNGNAGNVPE---------HQLTQEEEMEEGSLSWRVYHHYIQAA 802

  Fly   730 CGVLV------FVVLIMLCIGTQILASGGDYFLSYWVK-------------------NTASSSTL 769
            .|.:|      |||||:      .|.....::||||::                   |.|.:..|
Human   803 GGYMVSCIIFFFVVLIV------FLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQL 861

  Fly   770 DIYYFT-AINVGLVIC-ALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFA 832
            ..|... .:|..|:|| .:..:.:|..:|..:||.|||.:|..:.|..:.||.|.|.||:||.||
Human   862 SFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFA 926

  Fly   833 NDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLI-NTFAMMLAFYYWRDFYLKTSRDVK 896
            .||.|:|:::|......:.:.|.:..::.::.|.:|:.|: ....|::.|.|:. .:.|.....|
Human   927 GDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYM-MFKKAIGVFK 990

  Fly   897 RLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLF 961
            |||..:|||::||...:|.||.:|...|..:..|.|:....|..::....|:|::|.....|::.
Human   991 RLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIM 1055

  Fly   962 C----------VAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSV 1016
            .          ||:.||...::|         :: :|:...|.:....|...|...|.|...|:|
Human  1056 TNLVTLAVALFVAFGISSTPYSF---------KV-MAVNIVLQLASSFQATARIGLETEAQFTAV 1110

  Fly  1017 ERVLEY-------KDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFT 1074
            ||:|:|       ..|..||       ...|:.||:.|:::.:|..::|.  .|:|.||.|::.|
Human  1111 ERILQYMKMCVSEAPLHMEG-------TSCPQGWPQHGEIIFQDYHMKYR--DNTPTVLHGINLT 1166

  Fly  1075 IQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFS 1138
            |:..|.||||||||:|||||..||||| ....|.||||.:|...|||.|||||:|:|||:|||.|
Human  1167 IRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLS 1231

  Fly  1139 GTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILR 1203
            ||:|:|||||:::.|.::|.|||...|.:.||:.|..|.:.:.|.|.|||||:|||:|:|||:||
Human  1232 GTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLR 1296

  Fly  1204 ENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSP 1268
            .::|:::|||||::|.:||.|||.|||..|:.||||.||||:.|:::.|.:|||..|.||||..|
Human  1297 NSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRP 1361

  Fly  1269 YELLTASKAKVFHGMVMQTGKAS 1291
             |:|......:| ..:|.|..:|
Human  1362 -EVLRKKPGSLF-AALMATATSS 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	456/1368 (33%)
		ABC_membrane	112..364	CDD:294371	78/270 (29%)
		ABCC_MRP_domain1	434..632	CDD:213217	95/198 (48%)
		ABC_membrane	736..955	CDD:294371	69/240 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	119/221 (54%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	457/1375 (33%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740