DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and YOR1

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1426	Identity:	436/1426 - (30%)
Similarity:	712/1426 - (49%)	Gaps:	161/1426 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQASKLPPNPRES----------AGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLG 55
            :.:.|:|..|:..          ..|:|::.|.:.||||..|.|:|:||.||:|........:|.
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    56 DEFFQGWEDEVARCRRK-------------GDSGRKP--SVLRVIGRVFGWRLIMSGITIAALEL 105
            |:|.:.......:.|:|             .::.:.|  :|||.:...|..:..|| |..|.|..
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMS-IVFAILAN 218

  Fly   106 GTRATVPLLLAGLISEFSEHGNGHSYNAQI---YAVLLIACILASVL-LTHPYMMGMMHL-AMKM 165
            .|....|::...||....|....||.:...   ||:  .||::..|. ||..:......| .::.
Yeast   219 CTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAI--GACLMMFVNGLTFNHFFHTSQLTGVQA 281

  Fly   166 RVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYE 230
            :..::.|..:|....|..:......|:|.:.::.||.|.:..|....||...|..|.|....|..
Yeast   282 KSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIV 346

  Fly   231 QIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFG 295
            .:|..:..||.|......:..:..::....|:...:.||.||.||.|:::.|::||.||||..:.
Yeast   347 NLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYE 411

  Fly   296 KLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLG-FVLGGGELTAERAFCVTAFYNI 359
            |.|..:|..|:|.:|:|.|.|..|::..::|..||..|:.|. :.:..|.......|...:.:.:
Yeast   412 KNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNIFASLSLFQV 476

  Fly   360 LRRTVSKFF-PSGMSQFAELLVSMRRITNFMMREEANVIDMSERR-------------------- 403
            |  ::..|| |..:....::::.:.|:.:.:...|.:...|.|.:
Yeast   477 L--SLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPKLALKMTHCSFEW 539

  Fly   404 ----------DEKAEEEQHLLKEVEKR-------SYPVGIGKEPDTLVEIKALRARWGQEQHDLV 451
                      :.|.|.:....|..:||       |......|..|.:     |:.|.|.|..:..
Yeast   540 EDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNM-----LKDRDGPEDLEKT 599

  Fly   452 ----LNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNAS 512
                ..::|..:::|:.:.:.||:|:|||||:.|:.|.:....|.|:|:|....... ||:.|||
Yeast   600 SFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNAS 663

  Fly   513 VRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRA 576
            |||||:||.|.:|::|..|::.|:|:.||::| .||.|.:||||.:|||||:|||.|||:||::.
Yeast   664 VRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKK 728

  Fly   577 DVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYE 641
            |:||.||.|||||:.||:|:.|||:.|.|..:..||.||||..:|.|..::::........||.:
Yeast   729 DIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVD 793

  Fly   642 EMLKSGQDFAQLLVESTQNSGGGD---EIITSPNLS--------RQSSALSTKSSNGSSSSLESM 695
            |:....|....||..|:|||...|   |.:.:..|.        ::.:.|..|::..|.::....
Yeast   794 ELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGK 858

  Fly   696 VEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVL---IMLCIGTQILASGGDYFLS 757
            :..:    ...||:|.|:...|.|.:|::|..|..|...|:.|   .:|.:||...:.....:||
Yeast   859 IVAD----GHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLS 919

  Fly   758 YWVKNTASSSTLDIYYFTAINVGLVICALLRTLLFFN--------ITMHSSTELHNTMFQGLSRT 814
            ||.:|...:.....|      :||....:....:|.|        :.:.:|..|:....:.:..|
Yeast   920 YWTENKFKNRPPSFY------MGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHT 978

  Fly   815 ALYFFHTNPSGRILNRFANDLGQVD-EVMPAVMLDCIQIFLTLTGIICVLCVTN-PWYLINTFAM 877
            .:.:..|.|.|||||||..|...:| |:..::.|...| |..:.| :||:|:.. ||:.|....:
Yeast   979 PMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQ-FANIVG-VCVMCIVYLPWFAIAIPFL 1041

  Fly   878 MLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSS 942
            ::.|....|.|..:.|::||||||.||.:|::.:..|.|:.||:|..:|:..:.:.|...:..:.
Yeast  1042 LVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNE 1106

  Fly   943 GYYTFVSTSRAFGYYLDLFCVAYVISVIL----HNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003
            ..|..|...|..|.:||:..:|:.:.:.|    ..|   |: :|..:|:.:|..|.:.|::...:
Yeast  1107 AGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRAF---PI-SAASVGVLLTYVLQLPGLLNTIL 1167

  Fly  1004 RQSAELENAMTSVERVLEY-KDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCV 1067
            |...:.||.|.|.||::.| .:|..|..:..| |..||:|||..|:::.:::...|.|  ..|.|
Yeast  1168 RAMTQTENDMNSAERLVTYATELPLEASYRKP-EMTPPESWPSMGEIIFENVDFAYRP--GLPIV 1229

  Fly  1068 LKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLS-YNDGAILIDSLDTNDIGLHDLRSKISIIP 1131
            ||.|:..|:..||:||.||||||||::::||:||: ...|.||||::|.:.:||.|||.|::|||
Yeast  1230 LKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIP 1294

  Fly  1132 QEPVLFSGTMRYNLDPFEQYPDDKLWKA-----------LEDVHLKEEISELPSG------LQSI 1179
            |:||||.||:|.|||||.:..||:||.|           |.:|.|::.......|      |...
Yeast  1295 QDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQA 1359

  Fly  1180 ISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHR 1244
            :.|.|:|||:|:|||:.|.||::|:::||::||||::||.:||..||..|..:|.|||:|.||||
Yeast  1360 VEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHR 1424

  Fly  1245 LNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENTKQN 1305
            |.||::.|::||::.|.|.||.:|:.|. :.:..:|..|..::|         :.||..:|
Yeast  1425 LKTIVNYDRILVLEKGEVAEFDTPWTLF-SQEDSIFRSMCSRSG---------IVENDFEN 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	430/1392 (31%)
		ABC_membrane	112..364	CDD:294371	66/257 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	87/202 (43%)
		ABC_membrane	736..955	CDD:294371	62/231 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	108/238 (45%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	433/1415 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I2258
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750