Protein Alignment CG31793 and YBT1

DIOPT Version :9

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_013052.1
• Gene: YBT1 / 850678
• SGDID: S000003971
• Length: 1661
• Species: Saccharomyces cerevisiae
• Alignment Length: 1478
• Identity: 436/1478 - (29%)
• Similarity: 718/1478 - (48%)
• Gaps: 266/1478 - (17%)

  Fly     4 SKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVAR 68
            |.:.|:|.....|...:.:.:....::|..|.:::..|::..:.:..:..:..:|....:.:|
Yeast   274 SWITPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKV-- 336

  Fly    69 CRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALE-----LGT-RATVPLLLAGLISEFSEHGN 127
             :||              |:|...|.........|:     ||: .:.:|.:|...|.|:.|..:
Yeast   337 -KRK--------------RIFSLNLFFFFSNYLVLQCFWAFLGSVLSFIPTVLLKRILEYVEDQS 386

  Fly   128 GHSYN-AQIY-AVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALR----LSRT--- 183
            ....| |..| .|:.:..||.::........| ..:.::|:..:.|.||.||||    .::|
Yeast   387 SAPSNLAWFYVTVMFVGRILVAICQAQALFFG-RRVCIRMKSIIISEIYTKALRRKISTNKTKPS 450

  Fly   184 ------------------SLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYE 230
                              |......|.::||::.|..:......:.|......:..::|...||.
Yeast   451 NEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYR 515

  Fly   231 QIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFG 295
            .:|.|:..|:.|:|..|||...|::....|:.:....||.|::.:||....|::||.::||..|.
Yeast   516 LLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFE 580

  Fly   296 KLIGQMRRSEMSSIRQMNLLRGILLSFE----------ITLGRIAIFVSLLGFVLGGGELTAERA 350
            |.|..:|.:|:|.:    |:|.|:.|..          :|....|.::.:.|.|     ||...|
Yeast   581 KDINTIRENELSLL----LMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEV-----LTTPVA 636

  Fly   351 FCVTAFYNILRRTVSKFFPSGMSQF-AELLVSMRRITNFMMREEAN-----VIDMSERRDEKAEE 409
            |...:.:.:||..:.:.  |.|..| .:..||:.|:.:|:...:..     .||.:..|
Yeast   637 FTALSLFTLLRDPLDRL--SDMLSFVVQSKVSLDRVQDFLNENDTKKYDQLTIDPNGNR------ 693

  Fly   410 EQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSG 474
                            ...|..|:        .|.::..|..|.::|:..:.|:|..||||.|||
Yeast   694 ----------------FAFENSTI--------SWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSG 734

  Fly   475 KSSLIQAILGELPPESGSVQV----------------SGKYSYASQEPWLFNASVRDNILFGLPM 523
            |:||:.|:|||:...:|.|.|                :...:|.||..||.|.:|::||||..|.
Yeast   735 KTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPF 799

  Fly   524 DKQRYRTVLKRCALERDLELLH-GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSA 587
            ::.||:.|::.|.|:||.|:|. ||.|.:||:|.:|||||:.|:.||||:|..|...||||.|||
Yeast   800 NEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSA 864

  Fly   588 VDTHVGRHLFDECMRG-FLGKQLVILVTHQLQF-LEDADLIVIMDKGHVSACGTYEEMLKSGQDF 650
            ||:|....::|.|:.| .:..:..|||:|.:.. |.:|:|:|:::.|.|...|...:||:.|
Yeast   865 VDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKG--- 926

  Fly   651 AQLLVESTQNSGGGDEIITSPNLSRQSSA--LSTKSS----------------NGSSSSLES--- 694
                      ..|.||::.|..|||.:|:  |:.|||                |.:||..|:
Yeast   927 ----------LFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKL 981

  Fly   695 ----MVEKEKPKPSAVSSQESRSGGQIGLSMYK---KYFGAGCGVLVFVVLIMLCIGTQILASGG 752
                ..|.|:.:...:..:|::..|.:||.:||   |.|| |..::.|:..:.|.  .|:|..|.
Yeast   982 QKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFG-GWKIVSFLASLFLI--AQLLYIGQ 1043

  Fly   753 DYFLSYW----------------------------------------VKNTASSSTLDIYY---F 774
            .:::..|                                        .:|..||....:||   :
Yeast  1044 SWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLY 1108

  Fly   775 TAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVD 839
            ..|.....:....:|:|.|...:::|.::.|.:...:..:.:.||...|:|||:|||:.|:..:|
Yeast  1109 LIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAID 1173

  Fly   840 -EVMPAV------MLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKR 897
             |:.|.:      :::|:...:.:|.|       .|.:|.....:.:.:|:...||:..||::||
Yeast  1174 QELTPYIQGAFYSLIECLSTVILITFI-------TPQFLSVAIVVSILYYFVGYFYMAGSRELKR 1231

  Fly   898 LEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFC 962
            .|:::|||:|.|||.||||:.||||.|.:...:.:..:..|.::..::.....:|...:.:|:..
Yeast  1232 FESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIG 1296

  Fly   963 VAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDP 1027
            ...:....|...||....::|..|:::|.|:..|....|.:|..:|:|..|.|||||.||.:::.
Yeast  1297 SLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQ 1361

  Fly  1028 EGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKS 1092
            | .:|...|..||: ||::||:...||||||.|  |.|.|:|.:||::....|:|||||||||||
Yeast  1362 E-PYNEHKEIPPPQ-WPQDGKIEVNDLSLRYAP--NLPRVIKNVSFSVDAQSKIGIVGRTGAGKS 1422

  Fly  1093 SLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKL 1156
            ::|.|||| |....|.|.||::|.:.:.|..||..|:||||:|.|||||::.||||::::.|.::
Yeast  1423 TIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQI 1487

  Fly  1157 WKALEDVHLKEEISELPSG----------------------LQSIISEGGTNFSVGQRQLVCLAR 1199
            ::||:.|:|..| .:|..|                      |.|.|||||:|.|.|||||:||||
Yeast  1488 FEALKRVNLISE-EQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLAR 1551

  Fly  1200 AILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVE 1264
            ::||..:|:::|||||::|..:||.||.|||.:|:..|:|||||||.:::|.||:||||||.|.|
Yeast  1552 SLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKE 1616

  Fly  1265 FGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAE-------NTKQN 1305
            :..||.|| .:|...|:.|...:|:  .|.|:::|:       |:|::
Yeast  1617 YDHPYSLL-LNKQSAFYSMCEHSGE--LDILIELAKKAFVEKLNSKKD 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	426/1437 (30%)
		ABC_membrane	112..364	CDD:294371	70/288 (24%)
		ABCC_MRP_domain1	434..632	CDD:213217	83/216 (38%)
		ABC_membrane	736..955	CDD:294371	60/268 (22%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	118/243 (49%)
YBT1	NP_013052.1	MRP_assoc_pro	<353..1639	CDD:188098	416/1356 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.800