DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and BPT1

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_013086.1	Gene:	BPT1 / 850645	SGDID:	S000003938	Length:	1559	Species:	Saccharomyces cerevisiae

Alignment Length:	1402	Identity:	431/1402 - (30%)
Similarity:	709/1402 - (50%)	Gaps:	195/1402 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILSSLMFCFALPIL---FKGRK------QTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRR 71
            :||.:.|.:...::   ::.:|      ..|.|.||       ...|:..||...||.|....|.
Yeast   221 VLSYITFIWMNKLIVETYRNKKIKDPNQLPLPPVDL-------NIKSISKEFKANWELEKWLNRN 278

  Fly    72 KGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHS------ 130
                    |:.|.|.:.||     ..|::|.|...|...:.::....:..|.:..|..:
Yeast   279 --------SLWRAIWKSFG-----RTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPP 330

  Fly   131 YNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVN 195
            .|....|:.|....:.||.||:.:.:|:....:.:|.:::|.:|:|:|||:.......:||.::|
Yeast   331 LNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILN 395

  Fly   196 LLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKL 260
            |:|.|:.|..|...:...:...|:::::....||..:|.|...|:..:.:.:|:..:|||...||
Yeast   396 LMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKL 460

  Fly   261 RLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRS-EMSSIRQMNLLRGIL----- 319
            ........|.|::.:.|:::.|:.||:|.||.|....:..:|.. |:.:.|::.::..::
Yeast   461 SKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWN 525

  Fly   320 -LSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMR 383
             :...:|.....:|     .:.....|:....|...:.:|||...:.. .||.::...|..|||.
Yeast   526 CVPLMVTCSTFGLF-----SLFSDSPLSPAIVFPSLSLFNILNSAIYS-VPSMINTIIETSVSME 584

  Fly   384 RITNFMMREEANVIDMS--ERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQE 446
            |:.:|::.:|   ||.|  ||.|..|:|          |:.|.         :|:..:...|..:
Yeast   585 RLKSFLLSDE---IDDSFIERIDPSADE----------RALPA---------IEMNNITFLWKSK 627

  Fly   447 Q---------------------HDLVLNNV-NMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPE 489
            :                     ..:.|.|: :...:||.||.|:|.||:|||:.::||||:||..
Yeast   628 EVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCM 692

  Fly   490 SGS--------VQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-H 545
            |||        :..|...:|.|||.|:.|||||:|||||...|:..|...:|.|.|..||::| .
Yeast   693 SGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPD 757

  Fly   546 GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRG---FLGK 607
            ||.|:|||:|.||||||:||:.||||||.|||:|||||.|||||..|.:::.:..:.|   .|..
Yeast   758 GDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKN 822

  Fly   608 QLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQL--LVE-------------- 656
            :.:||.|:.:..|:.:.:|..::.|.:...|.||:::....:.::|  |:|
Yeast   823 KTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDV 887

  Fly   657 ----------------STQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKP-- 703
                            ....|...||::|       .|.|....:|...:||.::    :|:|
Yeast   888 QTEHRSESEVDEPLQLKVTESETEDEVVT-------ESELELIKANSRRASLATL----RPRPFV 941

  Fly   704 --------SAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWV 760
                    ......|....|::...:|..|..| ||||..|:..:..|.|::.....:::|.||.
Yeast   942 GAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKA-CGVLGVVLFFLFMILTRVFDLAENFWLKYWS 1005

  Fly   761 K-NTASSSTLDIYYFTAIN--VGLVICAL--LRT-LLFFNITMHSSTELHNTMFQGLSRTALYFF 819
            : |..:.|...::.|..:.  :|:...|.  ||: ::....::..|.:||.:|.:.:.|:.:.||
Yeast  1006 ESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFF 1070

  Fly   820 HTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYW 884
            .|.|.|||:|||::|:..||..:..:.....:..||....:.::....||:|:....:::.:.|:
Yeast  1071 ETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYY 1135

  Fly   885 RDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDL--HSSGYYTF 947
            :.||:..||::|||.:::.||:.|..|.:|.|...|.|....:..|  |.||:.:  :....:.|
Yeast  1136 QTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFI--YLNYEKIQYNVDFVFNF 1198

  Fly   948 VSTSRAFGYYLDLFCVAYVIS---VILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAEL 1009
            .||:|.....|.......|::   :.|.........::|.:||.::.:|.:||.:.|.:|.:..:
Yeast  1199 RSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTI 1263

  Fly  1010 ENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFT 1074
            |..:.||||::||.:|.||....:| ||:|.::||.:|.:..|:.|.:|.  .|...||..::..
Yeast  1264 ETNIVSVERIVEYCELPPEAQSINP-EKRPDENWPSKGGIEFKNYSTKYR--ENLDPVLNNINVK 1325

  Fly  1075 IQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFS 1138
            |:|.||||||||||||||:|..|||| |...:|.|:||.:|.:||||.||||.::||||:...|.
Yeast  1326 IEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFE 1390

  Fly  1139 GTMRYNLDPFEQYPDDKLWKALEDVHLKEEISEL----PSG-------------LQSIISEGGTN 1186
            ||::.|||||.:|.:|:|.:|:|..|||..:.::    |.|             |...|:|.|:|
Yeast  1391 GTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSN 1455

  Fly  1187 FSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDS 1251
            .|||||||:|||||:|..::|||:|||||:||.:||.:||.|||.:|||.|:||||||::|::||
Yeast  1456 LSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDS 1520

  Fly  1252 DKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            ||::|:|.|.|.||.||.:|| :.|..:|:.:..:.|
Yeast  1521 DKIIVLDQGSVREFDSPSKLL-SDKTSIFYSLCEKGG 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	427/1385 (31%)
		ABC_membrane	112..364	CDD:294371	57/264 (22%)
		ABCC_MRP_domain1	434..632	CDD:213217	90/231 (39%)
		ABC_membrane	736..955	CDD:294371	60/226 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	120/238 (50%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	430/1399 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I751
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810