DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC12

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1342	Identity:	457/1342 - (34%)
Similarity:	717/1342 - (53%)	Gaps:	123/1342 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGD 74
            |...|.|.|.:.|.:..|::..|.::.:...|:::.....:..:|...|.:.|.:|..|
plant   228 PERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCWTEESRR------ 286

  Fly    75 SGRKPSVLRVIGRVFGWRLIMSGITIAALELG---TRATVPLLLAGLISEFSEHGNGHSYNAQIY 136
              .||.:||.:....|.|..::|| .....:|   ::...|::|:.|:....|  ...::...:|
plant   287 --PKPWLLRALNNSLGGRFWLAGI-FKVTRIGNDLSQFVGPVILSHLLRSMQE--GDPAWVGYVY 346

  Fly   137 AVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDL 201
            |.::...:...||....|...:..:..::|..:.:||:.|:|||:..:.....:|:|.|:::.|.
plant   347 AFIIFVGVTLGVLCEAQYFQNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMITTDA 411

  Fly   202 NRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTAL 266
            |...:.....|.||..|..::::...||:|:|:||.:|..||.|.:||||.:.....||..:...
plant   412 NALQQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISKMRKLTKEGLQ 476

  Fly   267 RTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRG----ILLSFEITLG 327
            .||:||.:.|||:|.:..:|.|.||:.|...|..:|..|:|..|:..||..    ||.|..:
plant   477 WTDKRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLLSAFNSFILNSIPV--- 538

  Fly   328 RIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMRE 392
             :...||...|||.||:||..|||...:.:.:||..:: ..|:.:||.....||::||...::.|
plant   539 -VVTVVSFGVFVLLGGDLTPARAFTSLSLFAVLRFPLN-MLPNLLSQVVNANVSLQRIEELLLSE 601

  Fly   393 EANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDT-LVEIKALRARWGQEQHDLVLNNVN 456
            |                      .:..::.|:    :|.| .:.||.....|..:.....|:::|
plant   602 E----------------------RILAQNPPL----QPGTPAISIKNGYFSWDSKTTKPTLSDIN 640

  Fly   457 MSLRRGQLVAVIGPVGSGKSSLIQAILGELP-PESGSVQVSGKYSYASQEPWLFNASVRDNILFG 520
            :.:..|.|||::|..|.||:|||.|:||||. .|:.||.:.|..:|..|..|:|||:||:|||||
plant   641 LEIPVGTLVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNATVRENILFG 705

  Fly   521 LPMDKQRYRTVLKRCALERDLELLHG-DGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDP 584
            ...:.:||...:...||:.||:||.| |.|.:||||.::||||:.|:.:|||||..:|||:.|||
plant   706 SDFESERYWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDP 770

  Fly   585 LSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQD 649
            |||:|.||...:||.||:..|..:..:|||:||.||...|.|:::.:|.:...||:.|:.|||..
plant   771 LSALDAHVAHQVFDSCMKDELRGKTRVLVTNQLHFLPLMDKIILVSEGMIKEEGTFVELSKSGIL 835

  Fly   650 FAQLL-----VESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQ 709
            |.:|:     :::||.....||     |:.:....::...|..:..|    .::.|.:.|.:..|
plant   836 FKKLMENAGKMDATQEVNTNDE-----NILKLGPTVTVDVSERNLGS----TKQGKRRRSVLIKQ 891

  Fly   710 ESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLDIYY- 773
            |.|..|.|..::..:|..|..|:.|.::|:...:.|::|......:||.|...:.|.:....:|
plant   892 EERETGIISWNVLMRYKEAVGGLWVVMILLACYLATEVLRVSSSTWLSIWTDQSTSKNYSPGFYI 956

  Fly   774 --FTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLG 836
              :..:..|.|......:......::|::..||:.|...:.|..:.||||||:||::|||:.|:|
plant   957 VVYALLGFGQVAVTFTNSFWLITSSLHAARRLHDAMLSSILRAPMLFFHTNPTGRVINRFSKDIG 1021

  Fly   837 QVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFA---------------MMLAFYYWRD 886
            .:|..:..:|    .:|:           ...|.|::|||               :::.||....
plant  1022 DIDRNVANLM----NMFM-----------NQLWQLLSTFALIGTVSTISLWAIMPLLILFYAAYL 1071

  Fly   887 FYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYD-----NYQDLHSSGYYT 946
            :|..|||:|:||::|.|||:|:.|...|.||.:|||..|       ||     |.:.:.::..:|
plant  1072 YYQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKA-------YDRMAKINGKSMDNNIRFT 1129

  Fly   947 FVSTS--RAFGYYLD-----LFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMR 1004
            ..:||  |.....|:     :..:....:|:.:...|.....|..:||.::..|.:|.::...:|
plant  1130 LANTSSNRWLTIRLETLGGVMIWLTATFAVLQNGNTNNQAGFASTMGLLLSYTLNITSLLSGVLR 1194

  Fly  1005 QSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLK 1069
            |::..||::.|||||..|.||..|.. :.....:|...||..|.:..:|:.|||.|  ..|.||.
plant  1195 QASRAENSLNSVERVGNYIDLPSEAT-DIIENNRPVCGWPSGGSIKFEDVHLRYRP--GLPPVLH 1256

  Fly  1070 GLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQE 1133
            ||:|.:.|.||||:||||||||||::|||||: ....|.|:||..|....||.|:|..:|||||.
plant  1257 GLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDCDVAKFGLTDVRRVLSIIPQS 1321

  Fly  1134 PVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLA 1198
            |||||||:|:|:|||.::.|..||:||...|:|:.||..|.||.:.:.|||.|||||||||:.||
plant  1322 PVLFSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNPFGLDAEVCEGGENFSVGQRQLLSLA 1386

  Fly  1199 RAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVV 1263
            ||:||.::|||:|||||:||.:||:|||.|||.:||.||:|.||||||||:|.||:||:.:|.|:
plant  1387 RALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKSCTMLVIAHRLNTIIDCDKILVLSSGQVL 1451

  Fly  1264 EFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENTKQN 1305
            |:.||.|||:...:..|. ||..||.|:..:|..:....::|
plant  1452 EYDSPQELLSRDTSAFFR-MVHSTGPANAQYLSNLVFERREN 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	448/1308 (34%)
		ABC_membrane	112..364	CDD:294371	78/255 (31%)
		ABCC_MRP_domain1	434..632	CDD:213217	89/199 (45%)
		ABC_membrane	736..955	CDD:294371	65/243 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	127/221 (57%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810