DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC1

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001031116.1	Gene:	ABCC1 / 839920	AraportID:	AT1G30400	Length:	1622	Species:	Arabidopsis thaliana

Alignment Length:	1333	Identity:	467/1333 - (35%)
Similarity:	728/1333 - (54%)	Gaps:	107/1333 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGD 74
            |...|.:..|:.|.:..|::..|.|:.|...|::......:..:|...|.:.|:.|:.:
plant   227 PERHANLFDSIFFSWLNPLMTLGSKRPLTEKDVWHLDTWDKTETLMRSFQKSWDKELEK------ 285

  Fly    75 SGRKPSVLRVIGRVFGWRLIMSGITIAALELG---TRATVPLLLAGLISEFSEHGNGHSYNAQIY 136
              .||.:||.:....|.|....|.    .::|   ::...||||..|:.  |...|..::...||
plant   286 --PKPWLLRALNNSLGGRFWWGGF----WKIGNDCSQFVGPLLLNELLK--SMQLNEPAWIGYIY 342

  Fly   137 AVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDL 201
            |:.:...::..||....|...:|.:..::|.|:.:|::||:|||:........||::.||::.|.
plant   343 AISIFVGVVLGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRKKFQTGKITNLMTTDA 407

  Fly   202 NRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTAL 266
            ....:.....|.:|..|..:::|...||:|:|:||..|...|||..|:||.:...|.||..:...
plant   408 ESLQQICQSLHTMWSAPFRIIVALVLLYQQLGVASIIGALFLVLMFPIQTVIISKTQKLTKEGLQ 472

  Fly   267 RTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAI 331
            |||:|:.:|||:::.:..:|.|.||..|...:..:|..|:|..|:..||....:   ..|..|.:
plant   473 RTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKAQLLSAFNM---FILNSIPV 534

  Fly   332 FVSLLG---FVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREE 393
            .|:::.   |.|.||:||..|||...:.:::||..:. ..|:.::|.....||:.|:...:..||
plant   535 LVTVVSFGVFSLLGGDLTPARAFTSLSLFSVLRFPLF-MLPNIITQMVNANVSLNRLEEVLSTEE 598

  Fly   394 ANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMS 458
            ..::.                      :.|:..|:   ..:.|:.....|..:.....|:|:|:.
plant   599 RVLLP----------------------NPPIEPGQ---PAISIRNGYFSWDSKADRPTLSNINLD 638

  Fly   459 LRRGQLVAVIGPVGSGKSSLIQAILGELPPES-GSVQVSGKYSYASQEPWLFNASVRDNILFGLP 522
            :..|.||||:|..|.||:|||.|:|||||..| .:|.:.|..:|..|..|:|||:||||||||.|
plant   639 IPLGSLVAVVGSTGEGKTSLISAMLGELPARSDATVTLRGSVAYVPQVSWIFNATVRDNILFGAP 703

  Fly   523 MDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLS 586
            .|:::|..|:...||:.||||| .||.|.:||||.::||||:.|:.:|||||..:||.:||||||
plant   704 FDQEKYERVIDVTALQHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVCILDDPLS 768

  Fly   587 AVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFA 651
            |:|.|||:.:|::|::..||:...:|||:||.||...|.|:::.:|.|...|||||:..||..|.
plant   769 ALDAHVGQQVFEKCIKRELGQTTRVLVTNQLHFLSQVDKILLVHEGTVKEEGTYEELCHSGPLFQ 833

  Fly   652 QLLVESTQNSGGGDEIITSPNLSRQSSALSTKS-SNGSSSSLES---MVEKEKPKPSAVSSQESR 712
            :|:    :|:|..:: .:..|...:....|.|. .||::::|:.   ..:..|...|.:..:|.|
plant   834 RLM----ENAGKVED-YSEENGEAEVDQTSVKPVENGNANNLQKDGIETKNSKEGNSVLVKREER 893

  Fly   713 SGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLDIYY---F 774
            ..|.:...:.::|..|..|..|.::|::..:.||:.......:||.|..:....:...::|   :
plant   894 ETGVVSWKVLERYQNALGGAWVVMMLVICYVLTQVFRVSSSTWLSEWTDSGTPKTHGPLFYNIVY 958

  Fly   775 TAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVD 839
            ..::.|.|...|:.:......:::::.::|:.|...:.|..:.||.|||.|||:||||.|:|.:|
plant   959 ALLSFGQVSVTLINSYWLIMSSLYAAKKMHDAMLGSILRAPMVFFQTNPLGRIINRFAKDMGDID 1023

  Fly   840 EVMPAVMLDCI-----QIFLT--LTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKR 897
            ..: ||.::..     |:..|  |.||:..|.:   |.::   .:::.||....:|..|||::||
plant  1024 RTV-AVFVNMFMGSIAQLLSTVILIGIVSTLSL---WAIM---PLLVVFYGAYLYYQNTSREIKR 1081

  Fly   898 LEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYD-----NYQDLHSSGYYTFV--STSRAFG 955
            :::..|||:|:.|...|.||.:|||..|       ||     |.:.:.::..:|.|  :.:|..|
plant  1082 MDSTTRSPVYAQFGEALNGLSSIRAYKA-------YDRMAEINGRSMDNNIRFTLVNMAANRWLG 1139

  Fly   956 YYLDLFCVAYV-ISVILHNFFNPPLHN----AGQIGLAITQALGMTGMVQWGMRQSAELENAMTS 1015
            ..|::.....| ::..|....|....|    |..:||.::.||.:|..:...:|.::..||::.|
plant  1140 IRLEVLGGLMVWLTASLAVMQNGKAANQQAYASTMGLLLSYALSITSSLTAVLRLASLAENSLNS 1204

  Fly  1016 VERVLEYKDLDPEGDFNSP---AEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQP 1077
            ||||..|.::..|    :|   ...:||..||..|.:..:|:.|||.|:.  |.||.|:||.|.|
plant  1205 VERVGNYIEIPSE----APLVIENNRPPPGWPSSGSIKFEDVVLRYRPEL--PPVLHGVSFLISP 1263

  Fly  1078 MEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTM 1141
            |:|||||||||||||||:|||||: ....|.||||..|....||.|||..:.||||.|||||||:
plant  1264 MDKVGIVGRTGAGKSSLLNALFRIVELEKGRILIDECDIGRFGLMDLRKVLGIIPQAPVLFSGTV 1328

  Fly  1142 RYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENR 1206
            |:|||||.::.|..||::||..|||:.|...|.||.:.::|.|.|||||||||:.||||:||.::
plant  1329 RFNLDPFSEHNDADLWESLERAHLKDTIRRNPLGLDAEVTEAGENFSVGQRQLLSLARALLRRSK 1393

  Fly  1207 ILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYEL 1271
            |||:|||||.||.:||.|||.|||.:||.||:|.||||||||:|.|||||:|:|.|.||.||..|
plant  1394 ILVLDEATAAVDVRTDVLIQKTIREEFKSCTMLIIAHRLNTIIDCDKVLVLDSGKVQEFSSPENL 1458

  Fly  1272 LTASKAKVFHGMVMQTGKASFDHLLKVAENTKQ 1304
            |:..::. |..||..||.|:.::|..:....|:
plant  1459 LSNGESS-FSKMVQSTGTANAEYLRSITLENKR 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	458/1300 (35%)
		ABC_membrane	112..364	CDD:294371	79/254 (31%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/199 (47%)
		ABC_membrane	736..955	CDD:294371	63/235 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	134/221 (61%)
ABCC1	NP_001031116.1	PLN03130	1..1622	CDD:215595	467/1333 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810