DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCG43

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_680694.3	Gene:	ABCG43 / 827189	AraportID:	AT4G15236	Length:	1390	Species:	Arabidopsis thaliana

Alignment Length:	1110	Identity:	220/1110 - (19%)
Similarity:	379/1110 - (34%)	Gaps:	349/1110 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 RRITNFMM--------REEANVIDMSERRD------------EKAEEEQHLLKEVEKRSYPVGIG 427
            :|||..:.        |.:..|:|:|:..|            ...::.:.||:::..|:..|||.
plant    39 KRITTALFCKRDEQGKRSQRRVMDVSKLEDLDRRLFIDELIRHVEDDNRVLLQKIRTRTDEVGID 103

  Fly   428 ------KEPDTLVEI-------KALRARWG-------------QEQHDLVLNNVNMSLRRGQLVA 466
                  :..|..||.       |.:...|.             ||....:|..|:..:|..::..
plant   104 LPKIEVRFSDLFVEAECEVVHGKPIPTLWNAIASKLSRFTFSKQEDKISILKGVSGIIRPKRMTL 168

  Fly   467 VIGPVGSGKSSLIQAILGELPPE---SGSVQVSGKY----------SYASQE----PWLFNASVR 514
            ::||.|.||::|:.|:.|.|.|.   .|.|..:|..          ||.||.    |.|   |||
plant   169 LLGPPGCGKTTLLLALSGRLDPSLKTRGEVSYNGHLFSEFVPEKTSSYVSQNDLHIPEL---SVR 230

  Fly   515 DNILFG---------LPMDKQRYR--------------TVLKRCALERDLELLHGD--------- 547
            :.:.|.         |.|.|:..|              ..:|..::|.....|..|
plant   231 ETLDFSGCFQGAGSRLEMMKEISRREKLKGIVPDPDIDAYMKAASIEGSKTNLQTDYILKILGLT 295

  Fly   548 ---GTIVGERG-ASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFL--- 605
               .|.||:.. ..:||||:.|:.....:........:|:..:.:|:.....:. .|::.|.
plant   296 ICADTRVGDASRPGISGGQKRRLTTGEMIVGPIKTLFMDEISNGLDSSTTFQIL-SCLQQFARLS 359

  Fly   606 -GKQLVILVTHQLQFLEDADLIVIMDKGHV-------SACGTYEE------MLKSGQDFAQLLVE 656
             |..||.|:....:..|..|.:::|.:|.:       ..|..:|:      ..||..:|.|
plant   360 EGTILVSLLQPAPETFELFDDLILMGEGKIIYHGPRDFICSFFEDCGFKCPQRKSVAEFLQ---- 420

  Fly   657 STQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSM 721
                     |:|:..:   |......:.......|::|.:||.|.....:..|:..|      ..
plant   421 ---------EVISRKD---QEQYWCHRDKPYCYVSIDSFIEKFKKSDLGLQLQDELS------KT 467

  Fly   722 YKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASS--------STLDIYYFTAIN 778
            |.|......|         |||        ..|.||.|....|.|        ....:|.|.:
plant   468 YDKSQTQKDG---------LCI--------RKYSLSNWDMFKACSRREFLLMKRNSFVYVFKS-- 513

  Fly   779 VGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMP 843
             ||:|......:..:..|..:...||.....|    :|:|       .::...|:.|.:
plant   514 -GLLIFIGSIAMTVYLRTGSTRDSLHANYLLG----SLFF-------SLIKLLADGLPE------ 560

  Fly   844 AVMLDCIQIFLTLT-GIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMY 907
                      |||| ..|.|.|.....|....:|           |...|..:|...:...|.::
plant   561 ----------LTLTVSRIAVFCKQKELYFYPAWA-----------YAIPSAILKIPISFLESFLW 604

  Fly   908 SHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYV---ISV 969
            :..:..::|.........:|.||     ...||.|    .:|..||.|.....|.||..   ||:
plant   605 TMLTYYVIGYSPEAGRFIRQVLI-----LFALHLS----CISMFRAIGAVFRDFDVATTIGSISI 660

  Fly   970 ILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQS---------------AELENAMTSVERV 1019
            :|.:.|          |..|.:...|...::||...|               |.:...|||..|.
plant   661 VLLSVF----------GGFIVRKPSMPSWLEWGFWLSPLSYAEIGLTSNEFFAPMWRKMTSENRT 715

  Fly  1020 LEYKDLDPEG--------------------DFNS------------------PAEKQPPKSWPKE 1046
            |..:.||..|                    .||:                  .:..:..:|..|:
plant   716 LGEQVLDARGLNFGNQSYWNAFGALIGFTLFFNTVFALALTFLKTSQRSRVIVSHDKNTQSSEKD 780

  Fly  1047 GKLVTKDL-SLRYEPDTNSPCVLKGLSFTIQPME---------------------KVGI----VG 1085
            .|:.:... :|.:||          |:||.|.::                     |.|:    :|
plant   781 SKIASHSKNALPFEP----------LTFTFQDVQYFIETPQGKKLQLLSDVTGAFKPGVLTALMG 835

  Fly  1086 RTGAGKSSLINALF-RLSYND--GAILIDSLDTNDIGLHDLRSKIS------------IIPQEPV 1135
            .:||||::|::.|. |.:..|  |.|.:...    :.:.|..|::|            :..||.:
plant   836 VSGAGKTTLLDVLSGRKTRGDIKGQIEVGGY----VKVQDTFSRVSGYCEQFDIHSPNLTVQESL 896

  Fly  1136 LFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARA 1200
            .:|..:|...:...:.....:.:.||.:.| |||.:...|:..|     :..:..||:.:.:|..
plant   897 KYSAWLRLPCNISSETKSAIVNEVLETIEL-EEIKDSLVGVPGI-----SGVTAEQRKRLTIAVE 955

  Fly  1201 ILRENRILVMDEATANVDPQTDALIQATIRNKFK-DCTVLTIAHR--LNTIMDSDKVLVM-DAGH 1261
            ::....|:.|||.|..:|.:..|::...::|..: ..||:...|:  ::.....|::::| :.|.
plant   956 LVSNPSIIFMDEPTTGLDARAAAIVMRAVKNIAETGRTVVCTIHQPSIDIFEAFDELILMKNGGK 1020

  Fly  1262 VVEFG 1266
            ::.:|
plant  1021 IIYYG 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	220/1110 (20%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217	59/274 (22%)
		ABC_membrane	736..955	CDD:294371	45/227 (20%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	54/265 (20%)
ABCG43	NP_680694.3	AAA	13..1390	CDD:333001	220/1110 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000