DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC10

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1287	Identity:	413/1287 - (32%)
Similarity:	680/1287 - (52%)	Gaps:	95/1287 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGDSGRK 78
            ||:.|:|.|.:...::.:|..:.|:..|:.:...|..|    :..:..:|:.:...:|:..|..:
plant   210 AGLFSTLSFWWLNSLIKRGNVKDLEEEDIPELRKEERA----ETCYSLFEENLIEQKRRLGSSCQ 270

  Fly    79 PSVLRVIGRVFGWR-LIMSG----ITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAV 138
            ||:|:|. .:..|| |:.||    :.|.|:..|     ||||...|. .:|......|...:.||
plant   271 PSILKVT-VLCVWRELLTSGFFAFMKIVAVSAG-----PLLLNAFIL-VAEGNASFRYEGLVLAV 328

  Fly   139 LLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNR 203
            ||....:...|....:......:.:::|..:::||.:|.|||:.:|....:..:::|..:.|..|
plant   329 LLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYR 393

  Fly   204 FDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRT 268
            .......||.||....:||||...|:..:|:|:|..:::::|.:.....::::.:|.:.:.....
plant   394 IGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQ 458

  Fly   269 DQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIR--QMNLLRGILLSFEITLGRIAI 331
            |:|::..||.:..::|:|:|.||..|.|:|.::|..|:.|::  ||......:|.:.     ..:
plant   459 DERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWS-----SPV 518

  Fly   332 FVSLLGFV---LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREE 393
            |||...|.   .....|.|...|...|...:::..| :..|..:....:..|:..||..|:   |
plant   519 FVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPV-RMIPDVIGVTIQAKVAFSRIATFL---E 579

  Fly   394 ANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARW---GQEQHDLVLNNV 455
            |..:...|||.::..|                 |.:  ..:.||:....|   |..:.:  |.||
plant   580 APELQGGERRRKQRSE-----------------GNQ--NAIIIKSASFSWEEKGSTKPN--LRNV 623

  Fly   456 NMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFG 520
            ::.::.|:.|||.|.||||||:|:.|||||.|..||::...|..:|.||..|:...::|||||||
plant   624 SLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFG 688

  Fly   521 LPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDP 584
            ..||:.|||..:::.:|::||||| .||.|.:||||.:|||||:.||.||||:|:.||:||||||
plant   689 GVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDP 753

  Fly   585 LSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQD 649
            .||||.|....||.|.:...|..:.|:|||||:.||...|.:::|..|.::...||:|:|...:|
plant   754 FSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRD 818

  Fly   650 FAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSG 714
            | |.||.:.:.:.|.:.::...|.::     ..|..|...||...::     |||.:..||.|..
plant   819 F-QDLVNAHRETAGSERVVAVENPTK-----PVKEINRVISSQSKVL-----KPSRLIKQEEREK 872

  Fly   715 GQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW----VKNTASSSTLDIYYFT 775
            |..||..|.:|.....|.:.|.:..:    .|:..:.|....:.|    |.|...|:...|..:.
plant   873 GDTGLRPYIQYMNQNKGYIFFFIASL----AQVTFAVGQILQNSWMAANVDNPQVSTLKLILVYL 933

  Fly   776 AINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDE 840
            .|.:..|:|.::|::....:.|.||..|.:.:...|.|..:.|:.:.|.||||:|.::||..||.
plant   934 LIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDL 998

  Fly   841 VMPAVMLDCIQIFLTLTGI-----ICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEA 900
            .:|..:     ||:..:.:     :.||.:.....|..:..|:...:..:.:|.:|::::.|:..
plant   999 DVPFGL-----IFVVASSVNTGCSLGVLAIVTWQVLFVSVPMVYLAFRLQKYYFQTAKELMRING 1058

  Fly   901 VARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAY 965
            ..||.:.:|.:.::.|..||||...::....:.....|.::|.::...:.:......|:......
plant  1059 TTRSYVANHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFHSFAANEWLIQRLETVSAIV 1123

  Fly   966 VISVILHNFFNPP-LHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEG 1029
            :.|........|. ..::|.||:|::..|.:...:.:.::....|.|.:.||||:.:|..|.||
plant  1124 LASTAFCMILLPTGTFSSGFIGMALSYGLSLNMGLVYSVQNQCYLANWIISVERLNQYTHLTPE- 1187

  Fly  1030 DFNSP---AEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGK 1091
               :|   .|.:||.:||..|::...||.:||..:  ||.||||:|.|.:...|:|||||||:||
plant  1188 ---APEVIEETRPPVNWPVTGRVEISDLQIRYRRE--SPLVLKGISCTFEGGHKIGIVGRTGSGK 1247

  Fly  1092 SSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDK 1155
            ::||:||||| ....|.|::|.:|.:.||:|||||:..||||:|.||:||:|:||||..|:.|.:
plant  1248 TTLISALFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNGTVRFNLDPLCQHSDAE 1312

  Fly  1156 LWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1220
            :|:.|....|||.:.|..:||.|::.|.|:|:|:|||||.||.||:||.:|:||:|||||::|..
plant  1313 IWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRRSRVLVLDEATASIDNA 1377

  Fly  1221 TDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            ||.::|.|||.:|.||||:|:|||:.|:||...||.:..|.:||:..|.:|:
plant  1378 TDLILQKTIRREFADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPMKLM 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	413/1287 (32%)
		ABC_membrane	112..364	CDD:294371	63/256 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/201 (48%)
		ABC_membrane	736..955	CDD:294371	48/227 (21%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	113/221 (51%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	413/1287 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810