DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCG37

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_190916.1	Gene:	ABCG37 / 824516	AraportID:	AT3G53480	Length:	1450	Species:	Arabidopsis thaliana

Alignment Length:	1174	Identity:	231/1174 - (19%)
Similarity:	409/1174 - (34%)	Gaps:	363/1174 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 QFAEL--LVSMRRITNFM-------MREEA-NVID-----------MSERRDEKAEEEQ-HLLKE 416
            |:||:  |.:::|:.:.:       |.|:. .|:|           |.|:..:..|.:. .|||:
plant    60 QWAEIERLPTVKRMRSTLLDDGDESMTEKGRRVVDVTKLGAVERHLMIEKLIKHIENDNLKLLKK 124

  Fly   417 VEKRSYPVGIGKEPDTL---------------VEIKALRARW--------------GQEQHDL-- 450
            :.:|...||:  |..|:               ||.|||...|              |.:.|:.
plant   125 IRRRIDRVGM--ELPTIEVRYESLKVVAECEVVEGKALPTLWNTAKRVLSELVKLTGAKTHEAKI 187

  Fly   451 -VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSY------------- 501
             ::|:||..::.|:|..::||...||::|::|:.|.|   ..:::.||:.||
plant   188 NIINDVNGIIKPGRLTLLLGPPSCGKTTLLKALSGNL---ENNLKCSGEISYNGHRLDEFVPQKT 249

  Fly   502 ----ASQEPWLFNASVRDNILFGLPMDKQRYRT-------------------------------- 530
                :..:..:...:||:.:.|.........||
plant   250 SAYISQYDLHIAEMTVRETVDFSARCQGVGSRTDIMMEVSKREKEKGIIPDTEVDAYMKAISVEG 314

  Fly   531 ---------VLKRCALERDLELLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLS 586
                     :||...|:...|:|.||   |..||  :||||:.|:..|..:........:|:..:
plant   315 LQRSLQTDYILKILGLDICAEILIGD---VMRRG--ISGGQKKRLTTAEMIVGPTKALFMDEITN 374

  Fly   587 AVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADL---IVIMDKGHVSACGTYEEMLKSGQ 648
            .:|:.....:.....:........:||:......|..||   |::|.||.:...|...|:|...:
plant   375 GLDSSTAFQIVKSLQQFAHISSATVLVSLLQPAPESYDLFDDIMLMAKGRIVYHGPRGEVLNFFE 439

  Fly   649 DFAQLLVESTQNSGGGD---EIITS---------PNLSRQSSALSTKSSNGSSSSLESMVEKEKP 701
            |..   ....:..|..|   |:|:.         .:|.....::...|......|:...:|....
plant   440 DCG---FRCPERKGVADFLQEVISKKDQAQYWWHEDLPYSFVSVEMLSKKFKDLSIGKKIEDTLS 501

  Fly   702 KPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNT--- 763
            ||...|.....:   :..|:|.         |....|.:.||..:.|....:||: |..|..
plant   502 KPYDRSKSHKDA---LSFSVYS---------LPNWELFIACISREYLLMKRNYFV-YIFKTAQLV 553

  Fly   764 -ASSSTLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTA--LYFFHTNPSG 825
             |:..|:.::..|.:.:.::......:.|||.:.:     |....|..||.||  |..|:.....
plant   554 MAAFITMTVFIRTRMGIDIIHGNSYMSALFFALII-----LLVDGFPELSMTAQRLAVFYKQKQL 613

  Fly   826 RILNRFANDLGQVDEVMPAVMLDC-IQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYL 889
            .....:|       ..:||.:|.. :..|.:|.           |..::        ||...:..
plant   614 CFYPAWA-------YAIPATVLKVPLSFFESLV-----------WTCLS--------YYVIGYTP 652

  Fly   890 KTSRDVKR---LEAVARSPMYSHFSATLVGLPTIRAMGA-QQTLIGQYDNYQDLHSSGYYTFVST 950
            :.||..|:   |.||       ||::    :...|.:.| .||::...                |
plant   653 EASRFFKQFILLFAV-------HFTS----ISMFRCLAAIFQTVVASI----------------T 690

  Fly   951 SRAFGYYLDLFCVAYVI------SVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAEL 1009
            :.:||.........:||      :.:...|:..|| :.|:|||::.:.|.    .:|...|
plant   691 AGSFGILFTFVFAGFVIPPPSMPAWLKWGFWANPL-SYGEIGLSVNEFLA----PRWNQMQ---- 746

  Fly  1010 ENAMTSVERVLEYKDLDPEGD---------------FN-----------SPAEKQPPKSWPKEGK 1048
            .|..|....:|:.:.:|..|.               ||           ||...:...|..|..:
plant   747 PNNFTLGRTILQTRGMDYNGYMYWVSLCALLGFTVLFNIIFTLALTFLKSPTSSRAMISQDKLSE 811

  Fly  1049 L-----VTKDLSLRYEPDTNSP--------CVL--KGLSFTIQ--------PMEK---------- 1080
            |     .|:|.|:| :..|:||        .||  |.|:.|.|        |:|.
plant   812 LQGTEKSTEDSSVR-KKTTDSPVKTEEEDKMVLPFKPLTVTFQDLNYFVDMPVEMRDQGYDQKKL 875

  Fly  1081 ---------------VGIVGRTGAGKSSLINALF---RLSYNDGAILIDSLDTNDIGLHDLRSKI 1127
                           ..::|.:||||::|::.|.   ...|.:|.|.|.....    :.:..:::
plant   876 QLLSDITGAFRPGILTALMGVSGAGKTTLLDVLAGRKTSGYIEGDIRISGFPK----VQETFARV 936

  Fly  1128 S------------IIPQEPVLFSGTMRYNLDP-FEQYPDDKLWK-ALEDVHLKEEISELPSGLQS 1178
            |            |..:|.|::|..:|  |.| .:.....|..| .||.:    |:.|:...|..
plant   937 SGYCEQTDIHSPNITVEESVIYSAWLR--LAPEIDATTKTKFVKQVLETI----ELDEIKDSLVG 995

  Fly  1179 IISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAH 1243
            :  .|.:..|..||:.:.:|..::....|:.|||.|..:|.:..|::...::|
plant   996 V--TGVSGLSTEQRKRLTIAVELVANPSIIFMDEPTTGLDARAAAIVMRAVKN------------ 1046

  Fly  1244 RLNTIMDSDKVLV----MDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAE--NT 1302
                :.|:.:.:|    ..:..:.|......||......::.|.:.|..:...::...|.|  ..
plant  1047 ----VADTGRTIVCTIHQPSIDIFEAFDELVLLKRGGRMIYTGPLGQHSRHIIEYFESVPEIPKI 1107

  Fly  1303 KQNH 1306
            |.||
plant  1108 KDNH 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	223/1137 (20%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217	55/275 (20%)
		ABC_membrane	736..955	CDD:294371	44/229 (19%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	58/289 (20%)
ABCG37	NP_190916.1	PLN03140	54..1450	CDD:215599	231/1174 (20%)
		ABC_trans_N	89..167	CDD:291196	19/79 (24%)
		ABCG_PDR_domain1	186..429	CDD:213200	49/250 (20%)
		ABC2_membrane	530..735	CDD:279410	54/264 (20%)
		PDR_assoc	742..804	CDD:285559	11/65 (17%)
		ABCG_PDR_domain2	847..1085	CDD:213199	49/265 (18%)
		ABC2_membrane	1180..1387	CDD:279410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000