DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC8

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1317	Identity:	438/1317 - (33%)
Similarity:	691/1317 - (52%)	Gaps:	121/1317 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LPPNPRE------SAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWE- 63
            |..|||:      :||..|.|.|.:..|:|..|.|:.|.|.|:...:.|.||.....:|.|.|:
plant   198 LTKNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDT 262

  Fly    64 ---DEVARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALE-LGTRATV--PLLLAGLI--- 119
               ||.:...|.       .|.|.:.:|:    ....|.||... |.|.|.|  ||:|...:
plant   263 LLGDESSTKERN-------LVFRAVVKVY----FKENIFIAVFAFLRTFAVVSLPLMLYVFVDYA 316

  Fly   120 -SEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT 183
             |:..:..||. :|   .|.|::..::.|:.:.|.| .......|::|.|:..|.|:|.|:||..
plant   317 NSDHRDLRNGF-FN---LACLVMLKLVESLTMRHWY-FASRRSGMRIRSALMVAAYKKQLKLSSL 376

  Fly   184 SLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLP 248
            .....::|::||.::.|..|....|..||..|...|:||:::..|:..:|..:|.|:.:|:|...
plant   377 GRKRHSSGEIVNYIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGL 441

  Fly   249 LQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMN 313
            |....:::....:.|..:..|:|:|..:||::.::|||:.:||..|.|.|...|..|.:.:.:..
plant   442 LNLPFAKMLQNCQTQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQ 506

  Fly   314 LLR---GILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQF 375
            |.:   ..|.....|:....:|:...  :|....|.|...|.|.|...::...| |..|..:|..
plant   507 LTKAFGSFLYWMSPTIVSSVVFLGCA--LLKSAPLNASTIFTVLATLRVMSEPV-KIIPDAISAI 568

  Fly   376 AELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALR 440
            .:..||.:|:.||::.:|..                  :.|:|:......     .|.|:|:...
plant   569 IQGNVSFQRLNNFLLDDELK------------------MDEIERSGLDAS-----GTAVDIQVGN 610

  Fly   441 ARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQE 505
            ..|..|.....|.|:::.::.||.|||.||||:|||||:.|:|||:|..||:|:|.|..:|.||.
plant   611 FGWEPETKIPTLRNIHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQT 675

  Fly   506 PWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLE-LLHGDGTIVGERGASLSGGQRARICLA 569
            .|:.:.::|||||:|.||:.:||...:|.|||::|:. ..|||.|.:|:||.:|||||:.||.||
plant   676 SWIQSGTIRDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLA 740

  Fly   570 RAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHV 634
            ||||..|||||||||.||||.|....||.:|:...|.::.|||||||::||.:.|.|::|::|.:
plant   741 RAVYADADVYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEEGTI 805

  Fly   635 SACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESM---- 695
            :..|.|||:|..|..|.||:      :...|.:...|..|.:|  |......|....:.:|
plant   806 TQSGKYEELLMMGTAFQQLV------NAHNDAVTVLPLASNES--LGDLRKEGKDREIRNMTVVE 862

  Fly   696 -VEKEKPKPS----AVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYF 755
             :|:|..|..    .::.:|.:..|.:|:..:..|.|...|..:....::..:|..:..:...|:
plant   863 KIEEEIEKTDIPGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVLGQVGFVVFQAASTYW 927

  Fly   756 LSYWVKNTASSSTLDIYYFTAI---NVGLVICALLRTLLFFNITMHSSTELHNTMFQGLS----R 813
            |::.:.....::|:.|..::.|   :.|.|....:       .|.|...:.....|.|.:    :
plant   928 LAFAIGIPKITNTMLIGVYSIISTLSAGFVYARAI-------TTAHLGLKASKAFFSGFTNAVFK 985

  Fly   814 TALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMM 878
            ..:.||.:.|.||||.|.::||..:|..:|...:..:...:.||..:.::.......:|.....:
plant   986 APMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMTYVTWQVIIIALLAL 1050

  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSG 943
            .|....:|:||.::|::.|:....::|:.::.:.|.:|:.||||.|..:..   :.||.:|..:.
plant  1051 AATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFGTAERF---FKNYLNLVDAD 1112

  Fly   944 YYTFVSTSRAFGYYL---------DLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMV 999
            ...|..::.|..:.:         .||..|.::.:|...:..|     |.:||:::.||.:|...
plant  1113 AVLFFLSNAAMEWVILRIETLQNVTLFTCALLLILIPKGYIAP-----GLVGLSLSYALTLTQTQ 1172

  Fly  1000 QWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA---EKQPPKSWPKEGKLVTKDLSLRYEPD 1061
            .:..|....|.|::.||||:.:|.::..|    .||   :|:||.|||..|.:..::|.:||.|
plant  1173 VFLTRWYCTLSNSIISVERIKQYMNIPEE----PPAIIDDKRPPSSWPSNGTIHLQELKIRYRP- 1232

  Fly  1062 TNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRS 1125
             |:|.||||:|.|.:...:||:|||||:|||:||:||||| ....|.||||.:|.:.|||.|||.
plant  1233 -NAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISKIGLKDLRM 1296

  Fly  1126 KISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVG 1190
            |:|||||||.||.|.:|.||||...|.||::|||||...||..||.||:.|.|.:|:.|.|:|||
plant  1297 KLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSDEGENWSVG 1361

  Fly  1191 QRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVL 1255
            ||||.||.|.:|:.|:|||:|||||::|..|||:||..||.:|.||||:|:|||:.|::|||.|:
plant  1362 QRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPTVIDSDMVM 1426

  Fly  1256 VMDAGHVVEFGSPYELL 1272
            |:..|.:||:..|.:|:
plant  1427 VLSFGDLVEYNEPSKLM 1443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	438/1317 (33%)
		ABC_membrane	112..364	CDD:294371	66/258 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	99/198 (50%)
		ABC_membrane	736..955	CDD:294371	46/225 (20%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	123/221 (56%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810