DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC7

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	444/1332 - (33%)
Similarity:	691/1332 - (51%)	Gaps:	120/1332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGD 74
            |..:||.||.:.|.:..|::..|.::.:...|:.:..|...|..|      .|   :.|.:.:.|
plant   231 PFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDVPQVDNSDRAEKL------FW---IFRSKLEWD 286

  Fly    75 SG-RKPSVLRVIGRVF--GWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNG-HSYNAQI 135
            .| |:.:..::|..:|  .||.|:.....|.:...:....|.|:    ..|.::.|| ..|:.|
plant   287 DGERRITTYKLIKALFFSVWRDILLSTLFAFVYTVSCYVAPYLM----DTFVQYLNGQRQYSNQ- 346

  Fly   136 YAVLLIACILASVLL----THPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNL 196
             .|:|:.....:.|:    ...:...:....:.||..:.|.||.|.|.|...|..|.|:|:::||
plant   347 -GVVLVTTFFVAKLVECQARRNWYFRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEIINL 410

  Fly   197 LSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLR 261
            ::.|..|......:.|..|:..|::.:|...||..:|:.|....:...|.:.....|:::..|.:
plant   411 MTVDAERISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVMLGNIPLAKLEEKFQ 475

  Fly   262 LQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITL 326
            .......|.|::..:|.:..::::|:..||..|...|..:|..|...:::.......:.|   .|
plant   476 GNLMESKDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLKKFVYNSAAISS---VL 537

  Fly   327 GRIAIFVS--------LLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMR 383
            .....|||        ||...|..|::.|     ..|.:.||:..:.| .|..:|...:..||:.
plant   538 WAAPSFVSATAFGACMLLKIPLESGKIIA-----ALATFRILQTPIYK-LPDTISMIVQTKVSLD 596

  Fly   384 RITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQH 448
            ||..|:..::                    |::......|.|..|..   ||:......|.....
plant   597 RIATFLCLDD--------------------LQQDGMERLPSGSSKMD---VEVSNGAFSWDDSSP 638

  Fly   449 DLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASV 513
            ...|.::...:..|..:|:.|.||||||||:.:||||:|..||:::|.|:.:|.:|.||:.:..|
plant   639 IPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKV 703

  Fly   514 RDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRAD 577
            .:|||||.||.::.|:.||:.|:|.:|||:. ..|.|::||||.:|||||:.||.:|||:|:.||
plant   704 EENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQKQRIQIARALYQDAD 768

  Fly   578 VYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEE 642
            :||.|||.||||.|.|.|||.|.:.|.|..:.||.|||||:||.:||||::|..|.::..|.|.|
plant   769 IYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILVMKDGRITQAGKYNE 833

  Fly   643 MLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQS-SALSTKSSNGSSSSLESMVEKEKPKPSA- 705
            :|:||.||.:|:...|      |.:....:..:.| ||.||.|.....|:.|...|::.|.|..
plant   834 ILESGTDFMELVGAHT------DALAAVDSYEKGSASAQSTTSKESKVSNDEEKQEEDLPSPKGQ 892

  Fly   706 VSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW-------VKNT 763
            :..:|.|..|::|.::|:||.....|..:..:::::.|..|:|..|.:|::: |       ||..
plant   893 LVQEEEREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQVLNIGSNYWMA-WVTPVSKDVKPL 956

  Fly   764 ASSSTLDIYYF---TAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSG 825
            .|.|||.:.|.   ||.:..:::.|:|..:..|.|    :|||.|.|...:.|.::.||...|.|
plant   957 VSGSTLILVYVFLATASSFCILVRAMLSAMTGFKI----ATELFNQMHFRIFRASMSFFDATPIG 1017

  Fly   826 RILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYW-RDFYL 889
            |||||.:.|...||..:|:...:.....:.:.|||.|:... .|.::..|..::|...| |.:|:
plant  1018 RILNRASTDQSAVDLRLPSQFSNLAIAAVNILGIIGVMGQV-AWQVLIVFIPVIAACTWYRQYYI 1081

  Fly   890 KTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAF 954
            ..:|::.||..::|||:..|||.||.|:.|||:...:...........|.:|...:..:|.....
plant  1082 SAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPRFRTDIMRLNDCYSRLRFHAISAMEWL 1146

  Fly   955 GYYLDLF-CVAYVISVIL-----HNFFNPPLHNAGQIGLAITQALGMTGM---VQWGMRQSAELE 1010
            .:.|||. .||:.:|:::     ....||..     .|||:|.||.:..:   :.|.:   .:||
plant  1147 CFRLDLLSTVAFALSLVILVSVPEGVINPSF-----AGLAVTYALNLNSLQATLIWTL---CDLE 1203

  Fly  1011 NAMTSVERVLEYKDLDPEGDFNSPA----EKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGL 1071
            |.|.||||:|:|.|:..|     |:    ..:|.||||..|::...:|.:||.|  :.|.||:||
plant  1204 NKMISVERMLQYIDIPSE-----PSLVIESTRPEKSWPCRGEITICNLQVRYGP--HLPMVLRGL 1261

  Fly  1072 SFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPV 1135
            :.|.:...|.|||||||.|||:||..|||: ....|.|.||.::...||||||||::|||||||.
plant  1262 TCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILTIGLHDLRSRLSIIPQEPT 1326

  Fly  1136 LFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARA 1200
            :|.||:|.||||.|:|.||::|:||:...|.:||.:....|.|.:||.|.|:||||||||||.|.
plant  1327 MFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDSPVSENGQNWSVGQRQLVCLGRV 1391

  Fly  1201 ILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEF 1265
            :|:.:::|::|||||:||..||.|||.|:|..|..|||:|||||:::::|||.||::|.|.:.|.
plant  1392 LLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAHRISSVIDSDMVLLLDQGLIEEH 1456

  Fly  1266 GSPYELLTASKAKVFHGMVMQTGKASFDHLLK 1297
            .||..|| ..|:..|..:|.:. .||.|...|
plant  1457 DSPARLL-EDKSSSFSKLVAEY-TASSDSRFK 1486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	436/1306 (33%)
		ABC_membrane	112..364	CDD:294371	60/264 (23%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/198 (47%)
		ABC_membrane	736..955	CDD:294371	66/229 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	114/221 (52%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	439/1317 (33%)
		ABC_membrane	309..578	CDD:294371	62/282 (22%)
		ABCC_MRP_domain1	624..824	CDD:213217	94/199 (47%)
		ABC_membrane	925..1199	CDD:294371	81/284 (29%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	114/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810