DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC3

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1357	Identity:	447/1357 - (32%)
Similarity:	709/1357 - (52%)	Gaps:	160/1357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGD 74
            |...|||||.|.|.:..|::..|.|:||...|:.:..:......|..:|....|..        |
plant   245 PYSRAGILSLLTFSWMSPLIDIGNKKTLDLEDVPQLHDTDSVVGLAPKFRSMLESP--------D 301

  Fly    75 SGRKPSV--LRVIGRVF---GWRLIMSGI-----TIAALELGTRATVPLLLAGLISEFSEHGNG- 128
            .|.:..|  .::|..::   .|.::::..     |:|:. :|         ..||..|.::.||
plant   302 GGERSGVTTFKLIKALYFTAQWEILVTAFFAFIYTVASY-VG---------PALIDTFVQYLNGR 356

  Fly   129 HSYNAQIYAVLLIACILASV---LLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTT 190
            ..||.:.| ||:|....|.:   |....:...:..:.::||.|:.:.||.|.|.||..|..|.|:
plant   357 RQYNHEGY-VLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTS 420

  Fly   191 GQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSR 255
            |:::|.::.|..|......:.|..|:..|::.:|.:.||..:|:||...:...::.:.:.....|
plant   421 GEIINFMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFGR 485

  Fly   256 VTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILL 320
            :..:.:.:.....|.|::..:||:..::::|:..||..|...|..:|:||...:::. :....::
plant   486 MQERFQEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKY-VYNSAVI 549

  Fly   321 SFEI----TLGRIAIFVS--LLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELL 379
            ||..    ||..::.|.:  |||..|..|::.:     ..|.:.||:..:.. .|..:|...:..
plant   550 SFVFWGAPTLVSVSTFGACILLGIPLESGKILS-----ALATFRILQEPIYN-LPDTISMIVQTK 608

  Fly   380 VSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWG 444
            ||:.|:.:::..:.... |:.||                   .|.|   ..|..||:......|.
plant   609 VSLDRLASYLCLDNLQP-DIVER-------------------LPKG---SSDVAVEVINSTLSWD 650

  Fly   445 QEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLF 509
            ....:..|.::|..:..|..|||.|.||||||||:.::|||:|..|||::|.|..:|.:|.||:.
plant   651 VSSSNPTLKDINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQ 715

  Fly   510 NASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVY 573
            :..:.||||||.||:::||..||:.|:|.:|||:| .||.|::||||.:|||||:.||.:|||:|
plant   716 SGKIEDNILFGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALY 780

  Fly   574 RRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACG 638
            :.||:||.|||.||||.|.|.|||.|.:.|.|..:.||.||||::||..||||::|..|.:|..|
plant   781 QDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAG 845

  Fly   639 TYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSS-----------SL 692
            .|.::|.||.||.:|:       |...|.:...: |..::::|.||:.|..:           .|
plant   846 KYNDILNSGTDFMELI-------GAHQEALAVVD-SVDANSVSEKSALGQENVIVKDAIAVDEKL 902

  Fly   693 ESM------VEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASG 751
            ||.      :|..:|:...: .:|.|..|.:.|.:|.||.....|..:...:::..:..|:|..|
plant   903 ESQDLKNDKLESVEPQRQII-QEEEREKGSVALDVYWKYITLAYGGALVPFILLGQVLFQLLQIG 966

  Fly   752 GDYFLSYW-------VKNTASSSTLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQ 809
            .:|::: |       |:.....|||.|.| .|:..|..:|.|||..|.......::|||.:.|..
plant   967 SNYWMA-WATPVSEDVQAPVKLSTLMIVY-VALAFGSSLCILLRATLLVTAGYKTATELFHKMHH 1029

  Fly   810 GLSRTALYFFHTNPSGRILNRFANDLGQVDEVMP----AVMLDCIQIFLTLTGIICVLCVTNPWY 870
            .:.|:.:.||.:.|||||::|.:.|...||..:|    :|.:..||    |.|||.|:...: |.
plant  1030 CIFRSPMSFFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQ----LIGIIGVMSQVS-WL 1089

  Fly   871 LINTFAMMLAFYYW-RDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYD 934
            :...|..::|...| :.:|:..:|::.||..|.::|:..|||.|:.|..|||:.  .|....:.|
plant  1090 VFLVFIPVVAASIWYQRYYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSF--SQEFRFRSD 1152

  Fly   935 NYQDLHSSGY-----YTFVSTSRAFGYYLDL-------FCVAYVISVILHNFFNPPLHNAGQIGL 987
            |.:  .|.||     || ........:.||:       |.:.:::| |.....:|.|     .||
plant  1153 NMR--LSDGYSRPKFYT-AGAMEWLCFRLDMLSSLTFVFSLVFLVS-IPTGVIDPSL-----AGL 1208

  Fly   988 AITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAE-------KQPPKSWPK 1045
            |:|..|.:..:..|.:.....|||.:.||||:|:|..:        |:|       .:|.:|||.
plant  1209 AVTYGLSLNTLQAWLIWTLCNLENKIISVERILQYASV--------PSEPPLVIESNRPEQSWPS 1265

  Fly  1046 EGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAIL 1109
            .|::..:||.:||.|  :.|.||:|::.|.:...:.|||||||:|||:||..|||: ..:.|.|.
plant  1266 RGEVEIRDLQVRYAP--HMPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAGEIR 1328

  Fly  1110 IDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPS 1174
            ||.::...|||||||.::|||||:|.:|.||||.||||.|:|.||::|:||:...|.:|:.:...
plant  1329 IDGVNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRKKEQ 1393

  Fly  1175 GLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVL 1239
            .|.|.:||.|.|:|:||||||||.|.:|:.::|||:|||||:||..||.|||.|:|..|.||||:
plant  1394 KLDSSVSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDCTVI 1458

  Fly  1240 TIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQ---TGKASFD 1293
            |||||:::::|||.||::..|.:.|:.:|..|| ..|:..|..:|.:   ...:|||
plant  1459 TIAHRISSVIDSDMVLLLSNGIIEEYDTPVRLL-EDKSSSFSKLVAEYTSRSSSSFD 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	440/1332 (33%)
		ABC_membrane	112..364	CDD:294371	64/261 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	99/198 (50%)
		ABC_membrane	736..955	CDD:294371	69/235 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	112/221 (51%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	442/1340 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810