DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc6

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1356	Identity:	424/1356 - (31%)
Similarity:	669/1356 - (49%)	Gaps:	130/1356 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARC- 69
            |.|.|...|...|..||.:|..:|:||.::.|.|.||:....|:.:..|..:..:.|....:..
  Rat   206 LNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELP 270

  Fly    70 RRKGDSG---------------RKPSVLRVIGRVFGWRLIMSGITIAALEL----GTRATVPLLL 115
            ..||.||               ::..:||.|     ||:..|...:..|.|    ..|..||.||
  Rat   271 GHKGHSGMGTPETEAFLQPERSQRGPLLRAI-----WRVFRSTFLLGTLSLVISDAFRFAVPKLL 330

  Fly   116 AGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRL 180
            : |..||.......::...:.|||:........|....||..:..|.|::|.|::..:|||.|.|
  Rat   331 S-LFLEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVL 394

  Fly   181 SRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVL 245
            |..|...:..|.||||:|.|:.|....::|.:.|||..|.:::...:|::.:|.::...:::.:.
  Rat   395 SSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLS 459

  Fly   246 YLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIR 310
            .|||..::::..|..:.:...:...|.|:.:.::..::.||.:.||..|.:.:..:|..|:.:::
  Rat   460 LLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALK 524

  Fly   311 QMNLLRGI-LLSFEITLGRIAIFV-SLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMS 373
            ....|..: |:||:::...:|:.| ::...|.....:.||:||......:||.: ...|.|..:.
  Rat   525 TSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNK-AQAFLPFSVH 588

  Fly   374 QFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTL----- 433
            ...:..||..|:..|:..||.:                           |.|:...|...
  Rat   589 CLVQARVSFDRLAAFLCLEEVD---------------------------PNGMVLSPSRCSSKDR 626

  Fly   434 VEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGK 498
            :.|......|.||... .|:.:|:::.:|.|:||:||||:|||||:.|:||||....|||.:.|.
  Rat   627 ISIHNGTFAWSQESPP-CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGS 690

  Fly   499 YSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQ 562
            .:|..||.|:.|.||.:|:.|...:|....:.||:.|||..|: ....|..|.|||:|.:|||||
  Rat   691 VAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQ 755

  Fly   563 RARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLEDADL 625
            :.|:.|||||||||.|||:||||:|:|.||.:.:|.:.:  .|.|.....|||||.|..|..||.
  Rat   756 KQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQ 820

  Fly   626 IVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSG-------------------GGDEIITSP 671
            |:::..|.::..|:|:::|........||..:.|.:|                   ||......|
  Rat   821 ILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGGFSGGGTPTRRP 885

  Fly   672 NLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGA-GCGVLVF 735
            ...|.|.|...|.|...:....|:.:.|  .....:.::|...|::..:.|..|..| |..:..:
  Rat   886 ERPRPSDAAPVKGSTSEAQMEPSLDDVE--VTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTY 948

  Fly   736 VVLIMLCIGTQILASGGDYFLSYWV-------KNTASSSTLDIYYFTAINVGLVICALLRTL-LF 792
            .:.:.||  .|:.:....|:||.|.       |...|:....|:       ||:.|  |:.: ||
  Rat   949 TLFLFLC--QQVASFCQGYWLSLWADDPVVDGKQMHSALRGSIF-------GLLGC--LQAIGLF 1002

  Fly   793 FNIT------MHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQ 851
            .::.      ..:|..|..::...::|:.:.||...|.|.:||||:.:...||..:|..|...:.
  Rat  1003 ASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLT 1067

  Fly   852 IFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVG 916
            ....|..:...:.:..|..::....:||.:..::..|:.|...::|||:.:.|.:.||.:.|..|
  Rat  1068 YAFGLLEVGLAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQG 1132

  Fly   917 LPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLF-----CVAYVISVILHNFFN 976
            ...:||..||.....|:|...|.:....:..:...|.....|:|.     .||...:|:
  Rat  1133 SQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAVL------ 1191

  Fly   977 PPLH-NAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPP 1040
            ...| :||..|.:::.||.:|..:||.:|...:|||:|.:||||.:|.....|..:..|:....|
  Rat  1192 SKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQP 1256

  Fly  1041 KSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYN 1104
             .||..|::..:|..||:.|:.  |..::|:|..|...||||||||||||||||...|.|| ...
  Rat  1257 -LWPCGGQIEFRDFGLRHRPEL--PMAVQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEAT 1318

  Fly  1105 DGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEI 1169
            :|.|.||.:...|:|||.|||:|:||||:||||.|::|.|||..::..|:.:|.|||.|.||..:
  Rat  1319 EGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFV 1383

  Fly  1170 SELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFK 1234
            :.||..||...|..|.:.||||:||:|||||:||:.:||::|||||:|||.|:..:||.:...|.
  Rat  1384 TSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWFA 1448

  Fly  1235 DCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKA 1290
            .||||.|||||.::|:..:|||||.|.|.|.|||.:|| |.|. :|:.:..::|.|
  Rat  1449 QCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLL-AQKG-LFYRLAQESGLA 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	418/1337 (31%)
		ABC_membrane	112..364	CDD:294371	64/253 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	89/200 (45%)
		ABC_membrane	736..955	CDD:294371	53/232 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	113/221 (51%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	422/1353 (31%)
		ABC_membrane	313..577	CDD:294371	67/264 (25%)
		ABCC_MRP_domain1	627..828	CDD:213217	89/201 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		10/54 (19%)
		ABC_membrane	950..1215	CDD:294371	65/281 (23%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	113/221 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810