Protein Alignment CG31793 and ABCC8

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_001338224.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1603
• Species: Homo sapiens
• Alignment Length: 1453
• Identity: 431/1453 - (29%)
• Similarity: 707/1453 - (48%)
• Gaps: 245/1453 - (16%)

  Fly    28 ILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQ-----------GWEDEVARCRRKGDSGRKPSV 81
            |.||..::...|.||         ..||..|.|           .|.:...:...|     ||..
Human   196 IFFKTPREVKPPEDL---------QDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHK-----KPID 246

  Fly    82 LRVIGRV-----------------------------------------FGWRLIMSG-ITIAALE 104
            ||.||::                                         ||.||::|. ..|.|..
Human   247 LRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADL 311

  Fly   105 LGTRATVPLLLAGLISEFSEHGN---------GHSY--------NAQIYAVLL-IACILASVLLT 151
            ||...  ||.:.|::....:..:         |..:        ||.:.|||| :|.:|....|.
Human   312 LGFAG--PLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQ 374

  Fly   152 HPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFHF- 213
            ..|.:. :...:.:|.|:.:.||.|.:.||.:  |:|..|.||:.||::.|.|:    |:.|.|
Human   375 ASYYVA-IETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQ----LMWFFFL 434

  Fly   214 ---LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMM 275
               ||..|:::::....||..:|:::..|.::::|..|:|.:::...|:.:..|...:::|::..
Human   435 CPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQT 499

  Fly   276 NEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV- 339
            ||::.||:::|:|.||..|...:...||.||:|:|...:...|.:.....:...|:.::.:|.|
Human   500 NEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVS 564

  Fly   340 -LGGGELTAERAFCVTAFYNILRRTVSKFF--PSGMSQFAELLVSMRRITNFM----MREE---- 393
             ....:.:...||...:.::||   |:..|  .|.:....:.|||:::::.|:    :|||
Human   565 FFKEADFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAP 626

  Fly   394 --------ANVIDMSE--------------------------RRDEKAEEEQHLLKEVEKRSYPV 424
                    |:.....|                          .|...|.|:...|....:...|.
Human   627 HEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQSLVPS 691

  Fly   425 GIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPE 489
            ..|...:..|:|......|..:... .|:|:.:.:.||||..::|.||.|||||:.|.|||:...
Human   692 ADGDADNCCVQIMGGYFTWTPDGIP-TLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKV 755

  Fly   490 SGSV--------------------------QVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRY 528
            ||:|                          :..|..:||||:|||.||:|.:||:|..|.:||||
Human   756 SGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRY 820

  Fly   529 RTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHV 592
            :.|::.|:|:.|:::| |||.|.:||||.:||||||.||.:|||:|:.|:|..||||.||:|.|:
Human   821 KMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHL 885

  Fly   593 GRHLFD----ECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQL 653
            ..||..    |.:|.  .|:.|:||||:||:|..||.|:.|..|.:...||.::..:|.   .||
Human   886 SDHLMQAGILELLRD--DKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQL 945

  Fly   654 LVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLES----MVEKEKPKPSAVSSQES--- 711
            ...........|:.:....::.:.   :|:...|.|.::.|    :.::|:.:..|..|:|.
Human   946 FEHWKTLMNRQDQELEKETVTERK---ATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNL 1007

  Fly   712 ----RSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW----------VKN 762
                ....:|......||. :..|:|:..:|:...:...::....||:|:.|          .:|
Human  1008 SSMLHQRAEIPWRACAKYL-SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARN 1071

  Fly   763 TASSS--TLD--IY--YFTAI-NVGLVICALLRTLLFFNIT-----MHSSTELHNTMFQGLSRTA 815
            .:.|.  |||  :|  .||.: ::|:|:|      |..::|     :..:..||.::...:....
Human  1072 CSLSQECTLDQTVYAMVFTVLCSLGIVLC------LVTSVTVEWTGLKVAKRLHRSLLNRIILAP 1130

  Fly   816 LYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCI-QIFLTLTGIICVLCVTNPWYLINTFAMML 879
            :.||.|.|.|.|||||::|...:|:.:|:. |:|: :..|.....:.|:....|.:|:....:.:
Human  1131 MRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVSALAVISYVTPVFLVALLPLAI 1194

  Fly   880 AFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAM----GAQQTLIGQYDNYQDLH 940
            ..|:.:.::...|||:::|:...:.|:.|||:.|:.||.||||.    ..||.|:    .|.|.:
Human  1195 VCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLL----EYTDSN 1255

  Fly   941 SSGYYTFVSTSRAFGYYLDLF--CVAYVISVI-LHNFFNPPLHNAGQIGLAITQALGMTGMVQWG 1002
            :.......:.:|.....::..  ||..:.:|. :.|..:..| :||.:||.:|.||.::..:.|.
Human  1256 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHREL-SAGLVGLGLTYALMVSNYLNWM 1319

  Fly  1003 MRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCV 1067
            :|..|::|..:.:|:|:......:.|......|....||:||.:||:..::||:||  |::...|
Human  1320 VRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPV 1382

  Fly  1068 LKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIP 1131
            ||.::..|.|.:|:||.||||:||||...|.||: ...:|.|:||.:|...:.||.|||::|||.
Human  1383 LKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIIL 1447

  Fly  1132 QEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVC 1196
            |:|||||||:|:||||..:..|..||:|||...||..:..||.||.:||:|||.|||.|||||.|
Human  1448 QDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFC 1512

  Fly  1197 LARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGH 1261
            ||||.:|:..|.:||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.|:|:..|.
Human  1513 LARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGA 1577

  Fly  1262 VVEFGSPYELLTASKAKVFHGMV 1284
            ::||..|.:|| :.|..||...|
Human  1578 ILEFDKPEKLL-SRKDSVFASFV 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	431/1453 (30%)
ABCC8	NP_001338224.1	MRP_assoc_pro	224..1600	CDD:188098	421/1416 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1009		9/54 (17%)