DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31793 and ABCC8

DIOPT Version :9

Sequence 1:NP_609930.4 Gene:CG31793 / 326161 FlyBaseID:FBgn0051793 Length:1307 Species:Drosophila melanogaster
Sequence 2:XP_016873686.1 Gene:ABCC8 / 6833 HGNCID:59 Length:1604 Species:Homo sapiens


Alignment Length:1456 Identity:431/1456 - (29%)
Similarity:706/1456 - (48%) Gaps:250/1456 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 ILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQ-----------GWEDEVARCRRKGDSGRKPSV 81
            |.||..::...|.||         ..||..|.|           .|.:...:...|     ||..
Human   196 IFFKTPREVKPPEDL---------QDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHK-----KPID 246

  Fly    82 LRVIGRV-----------------------------------------FGWRLIMSG-ITIAALE 104
            ||.||::                                         ||.||::|. ..|.|..
Human   247 LRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARAIWQALSHAFGRRLVLSSTFRILADL 311

  Fly   105 LGTRATVPLLLAGLISEFSEHGN---------GHSY--------NAQIYAVLL-IACILASVLLT 151
            ||...  ||.:.|::....:..:         |..:        ||.:.|||| :|.:|....|.
Human   312 LGFAG--PLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQ 374

  Fly   152 HPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFHF- 213
            ..|.:. :...:.:|.|:.:.||.|.:.||.:  |:|..|.||:.||::.|.|:    |:.|.| 
Human   375 ASYYVA-IETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQ----LMWFFFL 434

  Fly   214 ---LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMM 275
               ||..|:::::....||..:|:::..|.::::|..|:|.:::...|:.:..|...:::|::..
Human   435 CPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQT 499

  Fly   276 NEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV- 339
            ||::.||:::|:|.||..|...:...||.||:|:|...:...|.:.....:...|:.::.:|.| 
Human   500 NEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVS 564

  Fly   340 -LGGGELTAERAFCVTAFYNILRRTVSKFF--PSGMSQFAELLVSMRRITNFM----MREE---- 393
             ....:.:...||...:.::||   |:..|  .|.:....:.|||:::::.|:    :|||    
Human   565 FFKEADFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAP 626

  Fly   394 --------ANVIDMSE--------------------------RRDEKAEEEQHLLKEVEKRSYPV 424
                    |:.....|                          .|...|.|:...|....:...|.
Human   627 HEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQSLVPS 691

  Fly   425 GIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPE 489
            ..|...:..|:|......|..:... .|:|:.:.:.||||..::|.||.|||||:.|.|||:...
Human   692 ADGDADNCCVQIMGGYFTWTPDGIP-TLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKV 755

  Fly   490 SGSV---------------------------QVSGKYSYASQEPWLFNASVRDNILFGLPMDKQR 527
            ||:|                           :..|..:||||:|||.||:|.:||:|..|.:|||
Human   756 SGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQR 820

  Fly   528 YRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTH 591
            |:.|::.|:|:.|:::| |||.|.:||||.:||||||.||.:|||:|:.|:|..||||.||:|.|
Human   821 YKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIH 885

  Fly   592 VGRHLFD----ECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQ 652
            :..||..    |.:|.  .|:.|:||||:||:|..||.|:.|..|.:...||.::..:|.   .|
Human   886 LSDHLMQAGILELLRD--DKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQ 945

  Fly   653 LLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLES----MVEKEKPKPSAVSSQES-- 711
            |...........|:.:....::.:.   :|:...|.|.::.|    :.::|:.:..|..|:|.  
Human   946 LFEHWKTLMNRQDQELEKETVTERK---ATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDN 1007

  Fly   712 -----RSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW----------VK 761
                 ....:|......||. :..|:|:..:|:...:...::....||:|:.|          .:
Human  1008 LSSMLHQRAEIPWRACAKYL-SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAAR 1071

  Fly   762 NTASSS--TLD--IY--YFTAI-NVGLVICALLRTLLFFNIT-----MHSSTELHNTMFQGLSRT 814
            |.:.|.  |||  :|  .||.: ::|:|:|      |..::|     :..:..||.::...:...
Human  1072 NCSLSQECTLDQTVYAMVFTVLCSLGIVLC------LVTSVTVEWTGLKVAKRLHRSLLNRIILA 1130

  Fly   815 ALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCI-QIFLTLTGIICVLCVTNPWYLINTFAMM 878
            .:.||.|.|.|.|||||::|...:|:.:|:. |:|: :..|.....:.|:....|.:|:....:.
Human  1131 PMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVSALAVISYVTPVFLVALLPLA 1194

  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAM----GAQQTLIGQYDNYQDL 939
            :..|:.:.::...|||:::|:...:.|:.|||:.|:.||.||||.    ..||.|:    .|.|.
Human  1195 IVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLL----EYTDS 1255

  Fly   940 HSSGYYTFVSTSRAFGYYLDLF--CVAYVISVILHNFFNPPLH---NAGQIGLAITQALGMTGMV 999
            ::.......:.:|.....::..  ||..:.:|   ...:..||   :||.:||.:|.||.::..:
Human  1256 NNIASLFLTAANRWLEVRMEYIGACVVLIAAV---TSISNSLHRELSAGLVGLGLTYALMVSNYL 1317

  Fly  1000 QWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNS 1064
            .|.:|..|::|..:.:|:|:......:.|......|....||:||.:||:..::||:||  |::.
Human  1318 NWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSL 1380

  Fly  1065 PCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKIS 1128
            ..|||.::..|.|.:|:||.||||:||||...|.||: ...:|.|:||.:|...:.||.|||::|
Human  1381 KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLS 1445

  Fly  1129 IIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQ 1193
            ||.|:|||||||:|:||||..:..|..||:|||...||..:..||.||.:||:|||.|||.||||
Human  1446 IILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQ 1510

  Fly  1194 LVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMD 1258
            |.|||||.:|:..|.:||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.|:|:.
Human  1511 LFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLK 1575

  Fly  1259 AGHVVEFGSPYELLTASKAKVFHGMV 1284
            .|.::||..|.:|| :.|..||...|
Human  1576 RGAILEFDKPEKLL-SRKDSVFASFV 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31793NP_609930.4 CFTR_protein 1..1273 CDD:273530 426/1443 (30%)
ABC_membrane 112..364 CDD:294371 69/277 (25%)
ABCC_MRP_domain1 434..632 CDD:213217 95/229 (41%)
ABC_membrane 736..955 CDD:294371 61/245 (25%)
ABCC_MRP_domain2 1047..1268 CDD:213211 110/221 (50%)
ABCC8XP_016873686.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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