DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcb9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001119906.1	Gene:	abcb9 / 570148	ZFINID:	ZDB-GENE-050517-12	Length:	789	Species:	Danio rerio

Alignment Length:	642	Identity:	165/642 - (25%)
Similarity:	292/642 - (45%)	Gaps:	85/642 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 LSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIG--LSMYKKYFGAGCGVLVF 735
            ||:..:|:|.:..:..:..|....|.|..|......:.:.||..||  ||..||..........|
Zfish   137 LSQTPNAVSDREDSEDTERLVDETEDESEKSMKSGKEHTHSGATIGRLLSYCKKDSSLLSIAFFF 201

  Fly   736 VVLIMLCIGTQILASGGDYFLSYW----VKNTASSSTLDIYYFTAINVGLVICALLRTLLF---- 792
            ::|..:|          :.|:.|:    :.......::|  :|....:.|.:.||:.::..
Zfish   202 LLLSAVC----------EAFIPYYTGQAIDGIVIQKSMD--HFAKPMITLSVLALVSSIAIGFRG 254

  Fly   793 --FNITM-HSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFL 854
              |::|. ..:..|.|.:|:.|....:.||..|.:|.|.:|..:|..||.:::...:...::.|:
Zfish   255 GVFSVTFARLNIRLRNLLFRSLMHQEIGFFDANHTGDITSRLTSDTTQVSDLISQNVNLFLRSFV 319

  Fly   855 TLTGIICVLCVTNPWYLINTFAMMLAFYY-------WRDFYLKTSRDVKRLEAVARSPMYSHFSA 912
            ...||. :......|.|  :...::.|.|       :.::|.|.:::|:  .|:|:        |
Zfish   320 KAVGIF-IFMFGMSWKL--SVVTIMGFPYIAVVSKLYGEYYKKLTKEVQ--TALAQ--------A 371

  Fly   913 TLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYT-----FVSTSRAFGYYLDLFCVAYVISVILH 972
            ..|...||.||...::...     :|.....||:     ||...:....|......:|:..:.|.
Zfish   372 NKVAEETISAMRTVRSFAN-----EDQEGDMYYSRLQEMFVLNKKQAIAYACFMWSSYISELALQ 431

  Fly   973 ---NFFNPPLHNAGQIG-----------LAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYK 1023
               .|:...|....|:.           |.:.:||.....|..|:.|      .:.:.|:|.||.
Zfish   432 VAILFYGGHLVVTNQMSGGTLISFVIYELELGEALESISSVYTGLMQ------GVGAAEKVFEYI 490

  Fly  1024 DLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTG 1088
            |..|:...|.   ::.|::  .||::...:::..| |......|||.:||:::|.:...:||.:|
Zfish   491 DRKPKHALNG---QEAPET--LEGQVEFNNVTFAY-PSRPEMDVLKNVSFSLRPGQVTALVGPSG 549

  Fly  1089 AGKSSLINALFRLSY--NDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLD-PFEQ 1150
            .||||.: .|....|  ..|.:|:|....|........||::::.||||||:.|::.|:. ...:
Zfish   550 GGKSSCV-CLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKVALVAQEPVLFARTVQMNISYGVPE 613

  Fly  1151 YPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATA 1215
            .|.:.:.:|..:.:..:.|:.|..|..|.:.|.||..|.||:|.|.:|||::|..|||::||||:
Zfish   614 APMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIRSPRILILDEATS 678

  Fly  1216 NVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            .:|.:::.::|..:.|..::.|||.|||||:|:..:|.:||:|.|.|||.|...||:
Zfish   679 ALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPHAELM 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	165/642 (26%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217
		ABC_membrane	736..955	CDD:294371	47/241 (20%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	78/223 (35%)
abcb9	NP_001119906.1	3a01208	46..745	CDD:273363	165/642 (26%)
		ABC_membrane	199..458	CDD:279056	54/288 (19%)
		P-loop_NTPase	500..725	CDD:304359	76/231 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000