DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31793 and Abcb9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	619	Identity:	158/619 - (25%)
Similarity:	282/619 - (45%)	Gaps:	118/619 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   747 ILASGGDYFLSYWVKNTASS----STLDIYYFTAINVGLVICAL-------------LRTLLFFN 794
            |:|:.|:.||.|:......|    .::| .:.||:   :|:|.|             :.||:|..
Mouse   192 IVAALGETFLPYYTGRAIDSIVIQKSMD-QFTTAV---VVVCLLAIGSSLAAGIRGGIFTLVFAR 252

  Fly   795 ITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFL----T 855
            :.:    .|.|.:|:.|......||..|.:|.:::|..:|...|.:::.    ..|.|||    .
Mouse   253 LNI----RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVS----QNINIFLRNTVK 309

  Fly   856 LTGIICVLCVTNPWYL-INTF-----AMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATL 914
            :||:: |...:..|.| :.||     .||::..|.: :|.:.|::|:  .|:||:...:  ..|:
Mouse   310 VTGVV-VFMFSLSWQLSLVTFMGFPIIMMVSNIYGK-YYKRLSKEVQ--SALARASTTA--EETI 368

  Fly   915 VGLPTIRAMGAQQ-------TLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILH 972
            ..:.|:|:...::       ..:.|........::.|.::|     :|..|.|..|.  :|::
Mouse   369 SAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYV-----WGSGLTLLVVQ--VSIL-- 424

  Fly   973 NFFNPPLHNAGQIG-----------LAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLD 1026
             ::...|..:||:.           ..:...:...|.|..|:.|      .:.:.|:|.|:.|..
Mouse   425 -YYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ------GVGAAEKVFEFIDRQ 482

  Fly  1027 P----EGDFNSPAEKQPPKSWPKEGKLVTKDLSLRY--EPDTNSPCVLKGLSFTIQPMEKVGIVG 1085
            |    :|.. :|..        .||::..::::..|  .|.|.   ||:.:||::.|.:...:||
Mouse   483 PTMVHDGSL-APDH--------LEGRVDFENVTFTYRTRPHTQ---VLQNVSFSLSPGKVTALVG 535

  Fly  1086 RTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHD---LRSKISIIPQEPVLFSGTMRYNLD 1146
            .:|:||||.:|.|... ....|.:|   ||...||.:|   |...||::.||||||:.::..|:.
Mouse   536 PSGSGKSSCVNILENFYPLQGGRVL---LDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNIS 597

  Fly  1147 ------PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILREN 1205
                  |||.     :.:|.:..:....|.||..|..:...|.|...|.||:|.|.:|||::|..
Mouse   598 YGLPTVPFEM-----VVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 657

  Fly  1206 RILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYE 1270
            .:|::||||:.:|.:::.|||..|....:..|||.|||||:|:..:..::|:|.|.||:.|:..:
Mouse   658 PVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQ 722

  Fly  1271 LLTASKAKVFHGMVMQTGKASFDHLLKVAENTKQ 1304
            ||....   .:..::|......:|.|....:.|:
Mouse   723 LLAQGG---LYAKLVQRQMLGLEHPLDYTASHKE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	153/586 (26%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217
		ABC_membrane	736..955	CDD:294371	53/241 (22%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	79/232 (34%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	154/598 (26%)
		ABC_membrane	189..451	CDD:279056	61/286 (21%)
		ABCC_TAP	489..714	CDD:213215	79/244 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000