Protein Alignment CG31793 and ABCC1

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Alignment Length: 1368
• Identity: 467/1368 - (34%)
• Similarity: 734/1368 - (53%)
• Gaps: 132/1368 - (9%)

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRR- 71
            |.|..||..||.:.|.:...::.:|.:|.|:.:||:....|..:..:.....:.|:.|.|:.|:
Human   260 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQ 324

  Fly    72 ------------------KGDSGRK--------------PSVLRVIGRVFGWRLIMSGITIAALE 104
                              |.|:..:              ||:.:|:.:.||...:||....|..:
Human   325 PVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHD 389

  Fly   105 LGTRATVPLLLAG-----LISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMK 164
            |       ::.:|     |:.:|........:....|.|||........|:.|.|........|:
Human   390 L-------MMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMR 447

  Fly   165 MRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLY 229
            ::.||..|:|||||.::.::...:|.|::|||:|.|..||.....:.:.:|..||::::|.|.|:
Human   448 IKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLW 512

  Fly   230 EQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPF 294
            ..:|.:...|::::||.:|:...::..|...::......|.|:::||||::||:|:|:|.||..|
Human   513 LNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAF 577

  Fly   295 GKLIGQMRRSEMSSIRQMNLLRG------ILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCV 353
            ...:..:|:.|:..:::...|..      :...|.:.|...|::|:    :.....|.|:.||..
Human   578 KDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT----IDENNILDAQTAFVS 638

  Fly   354 TAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVE 418
            .|.:||||..:: ..|..:|...:..||::|:..|:..||... |..|||
Human   639 LALFNILRFPLN-ILPMVISSIVQASVSLKRLRIFLSHEELEP-DSIERR--------------- 686

  Fly   419 KRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAIL 483
                ||..|...:: :.::.....|.:.... .||.:..|:..|.||||:|.||.|||||:.|:|
Human   687 ----PVKDGGGTNS-ITVRNATFTWARSDPP-TLNGITFSIPEGALVAVVGQVGCGKSSLLSALL 745

  Fly   484 GELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGD 547
            .|:....|.|.:.|..:|..|:.|:.|.|:|:|||||..:::..||:|::.|||..|||:| .||
Human   746 AEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGD 810

  Fly   548 GTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLV 610
            .|.:||:|.:|||||:.|:.||||||..||:||.||||||||.|||:|:|:..:  :|.|..:..
Human   811 RTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR 875

  Fly   611 ILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL-----VESTQN---------S 661
            |||||.:.:|...|:|::|..|.:|..|:|:|:|.....||:.|     .|..|:         |
Human   876 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVS 940

  Fly   662 GGGDE--------IIT---SPNLSRQSSALSTKSS-----NGSSSSLESMVEKEKPKPSAVSSQE 710
            |.|.|        ::|   ...|.||.|:.|:.|.     :.|::.|:. .|.:|.:...:...:
Human   941 GPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK-AEAKKEETWKLMEAD 1004

  Fly   711 SRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSST------- 768
            ....||:.||:|..|..| .|:.:..:.|.|.:...:.|...:|:||.|..:...:.|
Human  1005 KAQTGQVKLSVYWDYMKA-IGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 1068

  Fly   769 LDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFAN 833
            |.:|....|:.|:.:......:....|.  :|..||..:...:.|:.:.||...|||.::|||:.
Human  1069 LSVYGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSK 1131

  Fly   834 DLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRL 898
            :|..||.::|.|:...:.....:.|...|:.:..|...|....:.|.:::.:.||:.:||.:|||
Human  1132 ELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRL 1196

  Fly   899 EAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCV 963
            |:|:|||:||||:.||:|:..|||...|:..|.|.|...|.:...||..:..:|.....|:  ||
Human  1197 ESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLE--CV 1259

  Fly   964 AYVISVILHNFFNPPLH--NAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLD 1026
            ...|.:....|.....|  :||.:||:::.:|.:|..:.|.:|.|:|:|..:.:|||:.||.:.:
Human  1260 GNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETE 1324

  Fly  1027 PEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGK 1091
            .|..:.. .|..||.|||:.|::..::..|||..|.:  .||:.::.||...|||||||||||||
Human  1325 KEAPWQI-QETAPPSSWPQVGRVEFRNYCLRYREDLD--FVLRHINVTINGGEKVGIVGRTGAGK 1386

  Fly  1092 SSLINALFRLSYN-DGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDK 1155
            |||...|||::.: :|.|:||.::...|||||||.||:||||:||||||::|.|||||.||.|::
Human  1387 SSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1451

  Fly  1156 LWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1220
            :|.:||..|||:.:|.||..|....:|||.|.|||||||||||||:||:.:|||:|||||.||.:
Human  1452 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE 1516

  Fly  1221 TDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVM 1285
            ||.|||:|||.:|:||||||||||||||||..:|:|:|.|.:.|:|:|.:||  .:..:|:.|..
Human  1517 TDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL--QQRGLFYSMAK 1579

  Fly  1286 QTG 1288
            ..|
Human  1580 DAG 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	466/1366 (34%)
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	467/1368 (34%)