Protein Alignment CG31793 and Cftr

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1430
• Identity: 579/1430 - (40%)
• Similarity: 833/1430 - (58%)
• Gaps: 176/1430 - (12%)

  Fly     1 MQASKLP--PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWE 63
            |.:|..|  .|||:.|.|:|.|:|.:|:|:|::|.::.|...||.:.|.|..:..|||.....|.
  Fly     1 MDSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65

  Fly    64 DEVARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSE---- 124
            .|:.|..||   .:||.:...:.|.|....|::|: |..:.:..:..:|.:||.|:.:|.:
  Fly    66 KELERSHRK---KQKPHLRNALFRCFLGPTIINGL-ICFIYIVIKTLIPAVLAQLLIQFQKTPVA 126

  Fly   125 ---------------------------------HGNG---------------------------- 128
                                             :.:|
  Fly   127 QLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191

  Fly   129 ---------------HSYN--AQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRK 176
                           |.:|  ..:.|||:::.:....||.|..:...: :..:||:|..|.||||
  Fly   192 HNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL-MGARMRIACCSLIYRK 255

  Fly   177 ALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYG-I 240
            .||||..:.|.|..|.::||||||:||.|...|..|::|:.||:.::..|.::..||:.:..| :
  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320

  Fly   241 SILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSE 305
            .:|:..:|:||.||:|||.||::.|.|||.||.:|||::.||||||||.||:||..::.:.||||
  Fly   321 GLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSE 385

  Fly   306 MSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPS 370
            :..||..:.|||..||..:...|..::::|....|.|..:||:..|...::||||:...:.::|.
  Fly   386 IKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPL 450

  Fly   371 GMSQFAELLVSMRRITNFMMRE--EANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTL 433
            .:|..||.|||:|||.:|:|.|  |.....::.:||::..:.:                     .
  Fly   451 AVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSR---------------------A 494

  Fly   434 VEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGK 498
            |.||.:.|.|..|:....|.::|:.:.:|||.|||||||:||||::|.:|||||...|.|.:.|.
  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD 559

  Fly   499 YSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQ 562
            .|||:||||||..|||:|||||...|::||:.|.:.|||..|.:.| :||.|:||||||||||||
  Fly   560 LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQ 624

  Fly   563 RARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLG--KQLVILVTHQLQFLEDA 623
            ||||.||||||:.|.:||:||||||||.|||||||||.:  ||.|.  |...||||||:.||.:|
  Fly   625 RARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEA 689

  Fly   624 DLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVE-STQNSGGGDEIITSP---------------- 671
            |:|||:|:|.:...|||:|::.|..|||:||.. ..:..|......|||
  Fly   690 DVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFI 754

  Fly   672 --------NLSRQSSAL-STKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFG 727
                    .|.:|||:: .:||.:  |:.|:..|:::       ...|:::.|.|...::.:||.
  Fly   755 DGVKDGYQQLRKQSSSVHGSKSLD--STQLDDNVDED-------DLAEAQASGGISPRVWYEYFH 810

  Fly   728 AGCGVLVFVVLIMLCIGTQILASGGDYFLSYWV-------KNTASSSTLD-IYYFTAINVGLVIC 784
            ||..:|.|..::.:.:.:|::.|..|:|.:.|.       :..|:.||.: :|.:.|:.:.:||.
  Fly   811 AGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIM 875

  Fly   785 ALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDC 849
            ...|..|||.|.||:|..||:.||..:....:.||.|.|||||||||:.|:|.:||::|..|:|.
  Fly   876 TTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDF 940

  Fly   850 IQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATL 914
            |||.|.:.||:.|:.:.||..:.....:.:........||:.|:|:||||.:.|||::||.||:|
  Fly   941 IQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASL 1005

  Fly   915 VGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPL 979
            .||..||:...|..:..::|..||:|||.:...::.:...|.:||.....::.||......:...
  Fly  1006 TGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSET 1070

  Fly   980 HNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA--EKQPPKS 1042
            ..:|.:||||.||:.:|||||:|:||.||....||||||||:|.:|:.|     ||  ||.||:.
  Fly  1071 TYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-----PALGEKTPPQQ 1130

  Fly  1043 WPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGA 1107
            ||..|::..:::|.||:|: .|| ||:.|:.||:...||||||||||||||||.|||||::.:|.
  Fly  1131 WPTRGQVEFRNMSCRYDPN-GSP-VLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGE 1193

  Fly  1108 ILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISEL 1172
            |.||.::|..|.|..||::||||||:|||||.|:||||||||:|.|.:||.|||||.|::.|
  Fly  1194 IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI--- 1255

  Fly  1173 PSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCT 1237
             .||..:::|.|.|||||||||:||||||||.|::||:||||||||||||||||.|||.|||.||
  Fly  1256 -PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCT 1319

  Fly  1238 VLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENT 1302
            |||:||||:|:||||:::|||||..|||..||.||..|:..: ..||..||..| :.|.|.|.::
  Fly  1320 VLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATGGES-EALKKTASDS 1382

  Fly  1303  1302
              Fly  1383  1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	575/1419 (41%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	566/1389 (41%)