Protein Alignment CG31793 and CG5789

DIOPT Version :9

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1430
• Identity: 579/1430 - (40%)
• Similarity: 833/1430 - (58%)
• Gaps: 176/1430 - (12%)

  Fly     1 MQASKLP--PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWE 63
            |.:|..|  .|||:.|.|:|.|:|.:|:|:|::|.::.|...||.:.|.|..:..|||.....|.
  Fly     1 MDSSAKPTRKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWF 65

  Fly    64 DEVARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSE---- 124
            .|:.|..||   .:||.:...:.|.|....|::|: |..:.:..:..:|.:||.|:.:|.:
  Fly    66 KELERSHRK---KQKPHLRNALFRCFLGPTIINGL-ICFIYIVIKTLIPAVLAQLLIQFQKTPVA 126

  Fly   125 ---------------------------------HGNG---------------------------- 128
                                             :.:|
  Fly   127 QLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVD 191

  Fly   129 ---------------HSYN--AQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRK 176
                           |.:|  ..:.|||:::.:....||.|..:...: :..:||:|..|.||||
  Fly   192 HNATAVRSILDQTVEHMWNDMNSLGAVLVLSTLFCCFLLHHVDLRQRL-MGARMRIACCSLIYRK 255

  Fly   177 ALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYG-I 240
            .||||..:.|.|..|.::||||||:||.|...|..|::|:.||:.::..|.::..||:.:..| :
  Fly   256 TLRLSMKTAGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVV 320

  Fly   241 SILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSE 305
            .:|:..:|:||.||:|||.||::.|.|||.||.:|||::.||||||||.||:||..::.:.||||
  Fly   321 GLLLKTVPVQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSE 385

  Fly   306 MSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPS 370
            :..||..:.|||..||..:...|..::::|....|.|..:||:..|...::||||:...:.::|.
  Fly   386 IKQIRYASYLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPL 450

  Fly   371 GMSQFAELLVSMRRITNFMMRE--EANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTL 433
            .:|..||.|||:|||.:|:|.|  |.....::.:||::..:.:                     .
  Fly   451 AVSFGAEALVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSR---------------------A 494

  Fly   434 VEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGK 498
            |.||.:.|.|..|:....|.::|:.:.:|||.|||||||:||||::|.:|||||...|.|.:.|.
  Fly   495 VTIKDINASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGD 559

  Fly   499 YSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQ 562
            .|||:||||||..|||:|||||...|::||:.|.:.|||..|.:.| :||.|:||||||||||||
  Fly   560 LSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQ 624

  Fly   563 RARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLG--KQLVILVTHQLQFLEDA 623
            ||||.||||||:.|.:||:||||||||.|||||||||.:  ||.|.  |...||||||:.||.:|
  Fly   625 RARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEA 689

  Fly   624 DLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVE-STQNSGGGDEIITSP---------------- 671
            |:|||:|:|.:...|||:|::.|..|||:||.. ..:..|......|||
  Fly   690 DVIVIVDQGRILRQGTYQELINSDLDFARLLERPKEEEEGENSRNQTSPLSVNSLESDDEDIPFI 754

  Fly   672 --------NLSRQSSAL-STKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFG 727
                    .|.:|||:: .:||.:  |:.|:..|:::       ...|:::.|.|...::.:||.
  Fly   755 DGVKDGYQQLRKQSSSVHGSKSLD--STQLDDNVDED-------DLAEAQASGGISPRVWYEYFH 810

  Fly   728 AGCGVLVFVVLIMLCIGTQILASGGDYFLSYWV-------KNTASSSTLD-IYYFTAINVGLVIC 784
            ||..:|.|..::.:.:.:|::.|..|:|.:.|.       :..|:.||.: :|.:.|:.:.:||.
  Fly   811 AGSTLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFECMYIYGALIIAVVIM 875

  Fly   785 ALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDC 849
            ...|..|||.|.||:|..||:.||..:....:.||.|.|||||||||:.|:|.:||::|..|:|.
  Fly   876 TTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDF 940

  Fly   850 IQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATL 914
            |||.|.:.||:.|:.:.||..:.....:.:........||:.|:|:||||.:.|||::||.||:|
  Fly   941 IQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASL 1005

  Fly   915 VGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPL 979
            .||..||:...|..:..::|..||:|||.:...::.:...|.:||.....::.||......:...
  Fly  1006 TGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIISSET 1070

  Fly   980 HNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA--EKQPPKS 1042
            ..:|.:||||.||:.:|||||:|:||.||....||||||||:|.:|:.|     ||  ||.||:.
  Fly  1071 TYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE-----PALGEKTPPQQ 1130

  Fly  1043 WPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGA 1107
            ||..|::..:::|.||:|: .|| ||:.|:.||:...||||||||||||||||.|||||::.:|.
  Fly  1131 WPTRGQVEFRNMSCRYDPN-GSP-VLRNLNLTIEAGWKVGIVGRTGAGKSSLIGALFRLAHIEGE 1193

  Fly  1108 ILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISEL 1172
            |.||.::|..|.|..||::||||||:|||||.|:||||||||:|.|.:||.|||||.|::.|
  Fly  1194 IFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWSALEDVELRKAI--- 1255

  Fly  1173 PSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCT 1237
             .||..:::|.|.|||||||||:||||||||.|::||:||||||||||||||||.|||.|||.||
  Fly  1256 -PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDALIQRTIRIKFKQCT 1319

  Fly  1238 VLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENT 1302
            |||:||||:|:||||:::|||||..|||..||.||..|:..: ..||..||..| :.|.|.|.::
  Fly  1320 VLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATGGES-EALKKTASDS 1382

  Fly  1303  1302
              Fly  1383  1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	569/1399 (41%)
		ABC_membrane	112..364	CDD:294371	101/334 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	120/202 (59%)
		ABC_membrane	736..955	CDD:294371	79/226 (35%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	141/220 (64%)
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	570/1404 (41%)
		ABC_membrane	214..441	CDD:294371	92/227 (41%)
		ABCC_MRP_domain1	495..699	CDD:213217	120/203 (59%)
		ABC_membrane	863..1088	CDD:294371	83/224 (37%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	141/220 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I2776
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	9	8.960