DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Mrp4

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster

Alignment Length:	1322	Identity:	822/1322 - (62%)
Similarity:	1028/1322 - (77%)	Gaps:	43/1322 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQASKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDE 65
            |:|.:||.||||.:..|||||||||||:||||||:||:..|||:.|.||::.||||.....|:::
  Fly     4 MKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQ 68

  Fly    66 VARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHS 130
            ||:       ...|.:.|.:.:|||:.|.::|:.:.|.|..|:.|.|:.|.|:::.|:.:....|
  Fly    69 VAK-------NETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDPDRS 126

  Fly   131 YNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVN 195
             .||::|..|||..:.||.:.||||:|::||.||||:|:||.|||||||||||:||.||.|||||
  Fly   127 -KAQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVN 190

  Fly   196 LLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKL 260
            |||||:.|||..||:.|:||:.||||:..:|.:|.:||::|.:|::|::|:||.|:||.:.||.|
  Fly   191 LLSNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVL 255

  Fly   261 RLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEIT 325
            ||:||||||:||||||||||||||||||.||:||||::...|.:||..|:|:|.:||||:||.:.
  Fly   256 RLRTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMF 320

  Fly   326 LGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMM 390
            |.||....||:.|||.|..|.||:||.|||:||||||:|:.|||.|:|:|||||||:||:..||.
  Fly   321 LSRIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMH 385

  Fly   391 REEANVIDMS--ERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDL--V 451
            |.|..|.|.|  :..::|||.        .....|.|.| .|:.|:|....:|||  |.|.|  .
  Fly   386 RPETKVRDKSKVKNANQKAES--------PNGDSPKGNG-IPENLIEFSQFQARW--ESHSLEPT 439

  Fly   452 LNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDN 516
            |.::|:.|.|.:|||||||||:||||||||||||||.|||:::::|.||||:||||||..:||.|
  Fly   440 LEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQN 504

  Fly   517 ILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYL 580
            |||||..||.|||||:|:||||||.||| .||.||||||||||||||:|||.||||||||||:||
  Fly   505 ILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYL 569

  Fly   581 LDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLK 645
            ||||||||||||||||||:||||:|..:|||||||||||||.||||||||||.:||.|||..|.:
  Fly   570 LDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKR 634

  Fly   646 SGQDFAQLLVESTQNS--------GGGD--EIITSPNLSRQSSALSTKSS-NGSSSSLESMVEKE 699
            ||.||||||....:::        .|||  :::..|:|||:.|..|..|: |.|.:||.||.| .
  Fly   635 SGLDFAQLLTAPNKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAE-S 698

  Fly   700 KPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTA 764
            ..:.:::..||:|..|:|||.:||:|..:|....:...::.||:.||||.|..||||||||....
  Fly   699 MAQEASLQMQETRVEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNV 763

  Fly   765 SSST------LDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNP 823
            ...|      .|:|||.|:||.:|:..::||:||:.:.|.|||:|||.|:||::|.|:|||:|||
  Fly   764 DGQTDINTDPQDMYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNP 828

  Fly   824 SGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFY 888
            ||||||||:.||||:|||:|:||||.:|:||||.|||.|:|:|||:|||.|.|:.:.|||.|:||
  Fly   829 SGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFY 893

  Fly   889 LKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRA 953
            |||||||||||||||||:|||.|||:.|||||||:|||:.||.::||.|||||||||||::|:||
  Fly   894 LKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRA 958

  Fly   954 FGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVER 1018
            ||||||.||..|::.:||:.|.||| .:.|::|||||||:||||||||.|||||||||.||:|||
  Fly   959 FGYYLDCFCTLYIVIIILNYFINPP-QSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVER 1022

  Fly  1019 VLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGI 1083
            |:||.:::|||:|:|...|:|..|||::|:::.:||.|||.||..:..|||.|:|.|:|.|||||
  Fly  1023 VVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGI 1087

  Fly  1084 VGRTGAGKSSLINALFRLSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPF 1148
            |||||||||||||||||||||:|.|.||..||.|:||.||||||||||||||||||:||||||||
  Fly  1088 VGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPF 1152

  Fly  1149 EQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEA 1213
            |:|.|.|||.|||:|.||..|||||:||||.|||||:|||||||||||||||||||||:||||||
  Fly  1153 EEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEA 1217

  Fly  1214 TANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAK 1278
            |||||||||||||||||:||:||||||||||||||||||:||||||||:|||||||||||:|::|
  Fly  1218 TANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESK 1282

  Fly  1279 VFHGMVMQTGKASFDHLLKVAE 1300
            :||||||:||:.:||.||||||
  Fly  1283 IFHGMVMETGQNTFDSLLKVAE 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	802/1293 (62%)
		ABC_membrane	112..364	CDD:294371	147/251 (59%)
		ABCC_MRP_domain1	434..632	CDD:213217	148/200 (74%)
		ABC_membrane	736..955	CDD:294371	141/224 (63%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	178/220 (81%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	798/1285 (62%)
		ABC_membrane	93..359	CDD:294371	152/266 (57%)
		ABCC_MRP_domain1	422..622	CDD:213217	149/201 (74%)
		ABC_membrane	735..978	CDD:294371	152/242 (63%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	178/220 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455738
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	12	11.900