DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1410	Identity:	473/1410 - (33%)
Similarity:	756/1410 - (53%)	Gaps:	161/1410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG 73
            ||...|..||.:.|.:...:::||.|:.|...|:: .||::::...   ..|.:||.:|:..:|.
Zfish   207 NPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMW-DLNKNDSTHF---ICQTFEDVMAKELKKA 267

  Fly    74 DSG--RKPSVLRVIGRVFGWRLIMSGITIAALELGTR--------------------------AT 110
            .:.  :|.|..|......|...:..|::...|.:.|.                          .|
Zfish   268 RNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTT 332

  Fly   111 VPLLLAGLISE------------------------FSEHGNGHSYNAQIYAVLLIACILASVLLT 151
            :.....|::.|                        |:::.:.:::...:|||||:.......::.
Zfish   333 IVKSFKGVLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQSVVL 397

  Fly   152 HPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWL 216
            ..|......|.||:|.|:.:|:|:|||.:|..|...:|.|::|||:|.|..||:......|.||.
Zfish   398 QQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWS 462

  Fly   217 GPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISG 281
            .||::.::..||:.::|.:...|:.::||.:|:..:|:..:.:.::|.....|.|::::|::::|
Zfish   463 CPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNG 527

  Fly   282 IQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGI---LLSFE---ITLGRIAIFVSLLGFVL 340
            |:::|.|.||..|...:.::|..|:..:|:...|..:   :.|..   ::|...|:|||    |.
Zfish   528 IKILKYYAWETSFEAQVQEIREKELKVMRKFAYLSSVSTFIFSCAPALVSLATFAVFVS----VS 588

  Fly   341 GGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDE 405
            ....|.||:||...:.:||||..:: ..|..:|...:..||.:|:..|:..::.:...::
Zfish   589 PDNILDAEKAFTSISLFNILRFPLA-MLPQLISIMVQTSVSKKRLEKFLSGDDLDTTTVT----- 647

  Fly   406 KAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGP 470
                        ...|....:.....|..        | :...:.||..|::.::.|:||||:|.
Zfish   648 ------------HDSSITAAVSMTNGTYA--------W-ERDTEPVLKRVSLDIKPGRLVAVVGA 691

  Fly   471 VGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRC 535
            |||||:||:.|:||||....|::.::|..:|..|:.|:.||:::||||||..:|::||::|:|.|
Zfish   692 VGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILFGSSVDEERYQSVIKAC 756

  Fly   536 ALERDLELLHG-DGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDE 599
            ||..||:||.| |.|.:||:|.:|||||:.|:.||||||..||||||||||||||:|||:|||::
Zfish   757 ALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDDPLSAVDSHVGKHLFEK 821

  Fly   600 CM--RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL-------- 654
            .:  .|.|..:..||:||.:.||...|.||::..|.||..|:||.:..|...|::.|
Zfish   822 VIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRASKGAFSEFLETYGKDES 886

  Fly   655 ------------------VES------TQNSGGGDEIITSPNLSRQSSALSTK---SSNGS---- 688
                              :|:      ||..|..::|::| .|.|::|...::   ..|||
Zfish   887 NKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSS-TLKRENSLRHSQRHSKRNGSVKVR 950

  Fly   689 -SSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGA------GCGVLVFVVLIMLCIGTQ 746
             :|||.:..:.|..|...:..:|....|::..|:|.:|..|      |...:.:.:..:..||..
Zfish   951 KNSSLRAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGFSFVFYFIQNVAVIGQN 1015

  Fly   747 I-LASGGDYFLSYWVKNTASSSTLD--IYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMF 808
            : |:...|..:.|: ..|..:...|  |..|.|:.:.........|:|..:.::.:|..||.::.
Zfish  1016 LWLSDWTDDSIEYF-NQTYPNHIRDTRIGVFGALGLAQGFLVFFGTILLADGSISASRTLHTSLL 1079

  Fly   809 QGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLIN 873
            ..:.:..:.||.|.|||||:||||.|:..|||::|......|...|.:.|.:.|:|:..|.:...
Zfish  1080 TNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAV 1144

  Fly   874 TFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQD 938
            ...|.:.:|:.:.||:.|||.::||::|:|||:||||..|:.||..|||.|.|...:.:.::..|
Zfish  1145 VVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKRNEHTID 1209

  Fly   939 LHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003
            .:....|.::.::|.....|:......|....|....:....|:|.:||:|:.||.:|..:.|.:
Zfish  1210 QNLKSVYPWIVSNRWLAMRLESLGNLVVFFAALFAVISRDSLNSGLVGLSISYALNVTQTLNWLV 1274

  Fly  1004 RQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVL 1068
            |.::|||..:.:||||.||.::..|..:.:..  :||..||..|.:..:|..:||.|:..  .||
Zfish  1275 RMTSELETNIVAVERVREYAEIQNEAPWVTSV--RPPDDWPSAGNIRFEDYKVRYRPELE--LVL 1335

  Fly  1069 KGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQ 1132
            .|::..||..||:|||||||||||||.|.|||: ...||.||||.:|...:|||||||:::||||
Zfish  1336 HGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQ 1400

  Fly  1133 EPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCL 1197
            :|||||||:|.|||||:.:.|.::|..||..||||.:..||:||:..:||||.|.|:|||||:||
Zfish  1401 DPVLFSGTLRMNLDPFQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCL 1465

  Fly  1198 ARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHV 1262
            |||:||::|||::|||||.||.:||.|||:|||.:|..|||||||||||||:||.:|:|:|:|.:
Zfish  1466 ARALLRKSRILILDEATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKI 1530

  Fly  1263 VEFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAENTKQNHI 1307
            |||.||.|||  ||...|..|....|       ::..|...|:::
Zfish  1531 VEFDSPNELL--SKPGHFSSMAEDAG-------IRREEEQSQSYV 1566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	465/1374 (34%)
		ABC_membrane	112..364	CDD:294371	74/281 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/200 (48%)
		ABC_membrane	736..955	CDD:294371	66/221 (30%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	131/221 (59%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	471/1397 (34%)
		ABC_membrane	346..612	CDD:294371	72/269 (27%)
		ABCC_MRP_domain1	656..856	CDD:213217	97/208 (47%)
		ABC_membrane	1001..1270	CDD:279056	77/269 (29%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	131/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820