DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC6

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1345	Identity:	419/1345 - (31%)
Similarity:	685/1345 - (50%)	Gaps:	109/1345 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGW---------E 63
            |.|...|...|...|.:...::::|.::.|:|.||:....|:.:..|.....:.|         .
Human   214 PCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRH 278

  Fly    64 DEVARCRRKGDSGRKP---------------SVLRVIGRVFGWRLIMSGITIAALELGTRATVPL 113
            ::....:|||.||.|.               .:|:.|.:||....::..:::...:: .|.|||.
Human   279 NKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV-FRFTVPK 342

  Fly   114 LLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKAL 178
            ||: |..||.......::...:.|||:........|.....|..:..|.|::|.|::..:|||.|
Human   343 LLS-LFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVL 406

  Fly   179 RLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISIL 243
            .||..|...:..|.||||:|.|:.|....:::.:.|||..:.:::...:|::.:|.::...|::.
Human   407 ALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVF 471

  Fly   244 VLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSS 308
            :..|||..::|:..:..:.:...:.|.|.|:.:.|:...:.||.:.||..|...:..:|..|:.:
Human   472 LSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGA 536

  Fly   309 IRQMNLLRGI-LLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGM 372
            :|...||..: |:||:::...:|:.|..:..::....:.||:||......|||.: ...|.|..:
Human   537 LRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNK-AQAFLPFSI 600

  Fly   373 SQFAELLVSMRRITNFMMREEAN--VIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVE 435
            ....:..||..|:..|:..||.:  |:|.|                    |.....||:   .:.
Human   601 HSLVQARVSFDRLVTFLCLEEVDPGVVDSS--------------------SSGSAAGKD---CIT 642

  Fly   436 IKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYS 500
            |.:....|.||... .|:.:|:::.:|.|:||:||||:|||||:.|:||||....|.|.:.|..:
Human   643 IHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVA 706

  Fly   501 YASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRA 564
            |..||.|:.|.||.:|:.||..:|......||:.|||:.|::.. .|..|.:||:|.:|||||:.
Human   707 YVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQ 771

  Fly   565 RICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLEDADLIV 627
            |:.|||||||:|.||||||||:|:|.|||:|:|::.:  .|.|.....|||||.|..|..||.|:
Human   772 RLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWII 836

  Fly   628 IMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSS-- 690
            ::..|.::..|:|:|:|:. :.....|::..:..|...|..|.|       ..|||...|:|:
Human   837 VLANGAIAEMGSYQELLQR-KGALMCLLDQARQPGDRGEGETEP-------GTSTKDPRGTSAGR 893

  Fly   691 --------SLESMVEKEKPKPSAVS----SQESRSG----------GQIGLSMYKKYFGA-GCGV 732
                    |::|:.||::....|.:    ....|:|          |::..:::..|..| |..:
Human   894 RPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPL 958

  Fly   733 LVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLDIYYFTAINVGLVICALLRTL-LFFNIT 796
            .::.:.:.||  .|:.:....|:||.|..:.|...............||:.|  |:.: ||.::.
Human   959 CLYALFLFLC--QQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGC--LQAIGLFASMA 1019

  Fly   797 ------MHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLT 855
                  ..:|..|...:...:.|:.:.||...|.|.:||||:.:...||..:|..:...:.....
Human  1020 AVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFG 1084

  Fly   856 LTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTI 920
            |..:..|:.|..|...:....:.|.:..::..|:.:|..::|||:.:.|.:.||.:.|..|...:
Human  1085 LLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVV 1149

  Fly   921 RAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQI 985
            ||...|...:.|.:...|......:..:...|.....::|.....|.:.......:....:||.:
Human  1150 RAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLV 1214

  Fly   986 GLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSP-AEKQPPKSWPKEGKL 1049
            |.:::.||.:|..:||.:|...:|||::.||||:.:|.....|..:..| ...|||  ||:.|::
Human  1215 GFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQI 1277

  Fly  1050 VTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSL 1113
            ..:|..|||.|:.  |..::|:||.|...||||||||||||||||.:.|.|| ...:|.|.||.:
Human  1278 EFRDFGLRYRPEL--PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGV 1340

  Fly  1114 DTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQS 1178
            ....:|||.|||:||||||:|:||.|::|.|||..:::.|:.:|.|||.|.||..::.||..||.
Human  1341 PIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQY 1405

  Fly  1179 IISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAH 1243
            ..::.|.:.||||:||:|||||:||:.:||::|||||.|||.|:..:||.:.:.|..||||.|||
Human  1406 KCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAH 1470

  Fly  1244 RLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            ||.::||..:|||||.|.|.|.|||.:|| |.|. :|:.:..::|
Human  1471 RLRSVMDCARVLVMDKGQVAESGSPAQLL-AQKG-LFYRLAQESG 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	414/1328 (31%)
		ABC_membrane	112..364	CDD:294371	66/252 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	90/200 (45%)
		ABC_membrane	736..955	CDD:294371	49/225 (22%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	114/221 (52%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	419/1345 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810