DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and CG9270

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster

Alignment Length:	1309	Identity:	937/1309 - (71%)
Similarity:	1086/1309 - (82%)	Gaps:	38/1309 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQASKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDE 65
            |||.||..||||||||.|:|||||||||||||||:||:|||||..|.||:|.:|||:||..|:.|
  Fly     1 MQAKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE 65

  Fly    66 VARCRRKGDSGRK-PSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGH 129
            |..|   |||.:| ||::|||.:||||:|.:|||.:..||||||||:||:|..||:||:.:|||.
  Fly    66 VRSC---GDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGD 127

  Fly   130 SYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVV 194
            ...||||.:.||..||.|||:.||.|||:||||||||||||:||||||||||||:||.|||||||
  Fly   128 GLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVV 192

  Fly   195 NLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSK 259
            ||:||||.||||.||||||||||||||||:|||||:|||:||.|||.||:|:||:||:|||:||:
  Fly   193 NLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSR 257

  Fly   260 LRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEI 324
            ||.|||||||||||||||||||||||||||||:|||:||.::|||||||||::|.:||.||||||
  Fly   258 LRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEI 322

  Fly   325 TLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFM 389
            ||.|||||||||||||.||||||||||.||||||||||||.||||||||||||::|::|||..||
  Fly   323 TLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM 387

  Fly   390 MREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNN 454
            ||.|...:.:...:..|..|                  .||  ||::::.:|||..:..:.||.|
  Fly   388 MRSETEALYLKGGQTNKLFE------------------GEP--LVKLQSFQARWNHDHVEPVLEN 432

  Fly   455 VNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILF 519
            :|:||...|||||||||||||||||||||||||.|||.::|.|..||||||||||||||||||||
  Fly   433 INISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILF 497

  Fly   520 GLPMDKQRYRTVLKRCALERDLELLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDP 584
            ||||||.|||.|::.||||||.||||||.|.||||||||||||||||.|||||||:||.||||||
  Fly   498 GLPMDKHRYRNVIRNCALERDFELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDP 562

  Fly   585 LSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQD 649
            |||||||||||||:|||||||..:|||||||||||||.||||||||||.:||.||||||||||||
  Fly   563 LSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQD 627

  Fly   650 FAQLLVESTQNSGG---------GDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSA 705
            |.:||....|..|.         ||........|||||.:|..|.....||.||:::.|: :|
  Fly   628 FGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNER-QP-- 689

  Fly   706 VSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLD 770
              :|||||.|:|||.:|.|||.||.|.|:.:::...|:|||||||||||||||||||..|||:.|
  Fly   690 --AQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTD 752

  Fly   771 IYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDL 835
            ||.|:.||..|||.|||||||||::.|||||:||||||||:|||||||||.|||||||||||.||
  Fly   753 IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDL 817

  Fly   836 GQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEA 900
            |||||::|||||||||||||::|||.|||:|||||||||..|.|||::.|.|||.||||:|||||
  Fly   818 GQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEA 882

  Fly   901 VARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAY 965
            :|||||||||||||.||.|||||.||..|..:||||||:||||||||:||:||||||||||||||
  Fly   883 IARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAY 947

  Fly   966 VISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGD 1030
            ||||.|.::||||:.|.|||||.||||:.|||.|||||||||||||:||||||||||:.|:.||:
  Fly   948 VISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGE 1012

  Fly  1031 FNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLI 1095
            |.||.:|:||.:||:||.:..:.|||||.||..:..|||.|:|.|.|.||:||||||||||||||
  Fly  1013 FESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLI 1077

  Fly  1096 NALFRLSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKAL 1160
            |||||||||:|:::||:.|...|||||||||||||||||||||||:|.||||||||.|:|||:||
  Fly  1078 NALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEAL 1142

  Fly  1161 EDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALI 1225
            |:||||:|:||||:||:|:::|||:|:||||||||||||||||||||||||||||||||||||||
  Fly  1143 EEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALI 1207

  Fly  1226 QATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKA 1290
            |:|||.||:||||||||||||||:|||:|:|:|||.:||||||:||||.|.:|||:|||:|||::
  Fly  1208 QSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRS 1272

  Fly  1291 SFDHLLKVA 1299
            ||:||||:|
  Fly  1273 SFEHLLKLA 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	918/1281 (72%)
		ABC_membrane	112..364	CDD:294371	199/251 (79%)
		ABCC_MRP_domain1	434..632	CDD:213217	155/197 (79%)
		ABC_membrane	736..955	CDD:294371	167/218 (77%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	169/220 (77%)
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	916/1278 (72%)
		ABC_membrane	92..362	CDD:294371	210/269 (78%)
		ABCC_MRP_domain1	412..611	CDD:213217	156/198 (79%)
		ABC_membrane	718..981	CDD:294371	201/262 (77%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	169/220 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455737
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	12	11.900