DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1398	Identity:	462/1398 - (33%)
Similarity:	740/1398 - (52%)	Gaps:	181/1398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQT-LQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCRR 71
            :|.::||..|.:...:..|:.::..|.: |:..|:: .|:.|||:....:..:. |.:|:   :|
Zfish    60 HPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVW-GLSCHEASETNCQRLEWLWHEEL---KR 120

  Fly    72 KGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATV----PLLLAGLISEFSEHGNGHSYN 132
            :|..|..      :.||| ||...:.:.:|...|......    |.||...:.|||:    .|..
Zfish   121 RGKDGAS------LSRVF-WRFCQTRMLVAIFSLLITMVAGFVGPALLIRALLEFSQ----CSEV 174

  Fly   133 AQIYAVLLIACILASVLLTHPYMMGMM-----HLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQ 192
            ..:|.:.|:|.|.. :.||..:.:..|     ..|.::|.|..:..::|.|||..|.  ..::|:
Zfish   175 KLLYGLALVAGIFL-MELTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTK--DVSSGE 236

  Fly   193 VVNLLSNDLNRFDR-----CLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTY 252
            :||:.::|..|...     ||:....| :|.|.|...:|||    |..:..|.:|.:::.|....
Zfish   237 LVNICASDGQRLYEAVSVGCLLAGGPL-VGMLGLTYTTYFL----GPTALVGSAIFIIFYPTMML 296

  Fly   253 LSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRG 317
            .||:|:..|.:....||:|||:||||:..::.||||.||.||...|.::|..|..::.....::
Zfish   297 ASRMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEERRNLEWAGCVQ- 360

  Fly   318 ILLSFEITLG---RIAIFVSLLGFVLG---GGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFA 376
                 .:|||   .:.:..|:..|.|.   |.:|||.:||.|.|.:|.:...: |..|..:...:
Zfish   361 -----SLTLGVAPVVVVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMTFAL-KVTPLAVRALS 419

  Fly   377 ELLVSMRRITNFMMREEA-----------NVIDMSE----------------------------- 401
            |..|:::|.....|.|:.           ||::..:
Zfish   420 EGSVAVKRFQKLFMMEDRELISVKTEDPYNVVEFKDATLAWEKTCGSQTKKSRTQLKRGGMKRVL 484

  Fly   402 RRDE------------KAEE--EQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVL 452
            ||::            |.||  .:|||..:|:.|       ...|:...:::|....:     .|
Zfish   485 RREKLSLYIITEENKGKIEEPNAEHLLTHMEQES-------PQSTISSTQSIRPPLHK-----TL 537

  Fly   453 NNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNI 517
            :.:::.:::|.||.|.|.||||||||:.|:||::....|||.|:|.::|.:|:.|:.|.|:|:||
Zfish   538 HRIDLCIQKGSLVGVCGGVGSGKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLRENI 602

  Fly   518 LFGLPMDKQRYRTVLKRCALERD-LELLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLL 581
            |||...::::|..||:.|.|..| :||.:||.|.:|||||:||||||.|:.||||:|....:.||
Zfish   603 LFGKKYNEEKYNAVLEACCLFPDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPILLL 667

  Fly   582 DDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKS 646
            ||||||||..||..||...:|.....:.||.||||||:|.:.|.:|:|..|.::..||:.::::.
Zfish   668 DDPLSAVDARVGSRLFHSAIRPAAKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQLMEK 732

  Fly   647 GQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQ-- 709
            |:|:|.|.     ||      :...||.|::  |..|......||.:::.....|||...|.:
Zfish   733 GRDYAALF-----NS------VQQENLVRKN--LKNKEKAEKESSPQTLHVSNPPKPDTESKKTD 784

  Fly   710 -----ESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTL 769
                 |.:..|.:...:|..|..|..|.|.|:|.|:|.:.|....:..:::||||::..:.:|:|
Zfish   785 QLMQAEEKGSGAVAWPVYAAYIKAAGGPLAFIVTILLFLFTTGSIAFSNWWLSYWIRQGSGNSSL 849

  Fly   770 ----------------DIYYFTAINVGLVICAL----LRTLLFFNITMHSSTELHNTMFQGLSRT 814
                            .|.|::.:.|..:..||    :|.|:|...|:.:::.||:.:|:.|..:
Zfish   850 LLGNETAESDSMRLNPHIQYYSRVYVLSMGAALFLKTIRGLVFVKCTVRAASVLHDKLFKTLLLS 914

  Fly   815 ALYFFHTNPSGRILNRFANDLGQVD---EVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFA 876
            .:.||.|.|.|||||||:.|:.:||   .:...::|..:.:.|...|::..:.   ||:|.:...
Zfish   915 PMRFFDTTPLGRILNRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAVF---PWFLFSIIP 976

  Fly   877 MMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHS 941
            :....:..........|::||||.:::||..||.:::|.||.||.|.|.....|.:|....|.:.
Zfish   977 LGAFLFIVNRISRVLIRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQ 1041

  Fly   942 SGYYTFVSTSRAFGYYLDLFCVAYV-----ISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQW 1001
            :..:.|....|.....|||..::.:     :.|::|...:|     ...|||::.|:.:||:.|:
Zfish  1042 ACQFLFSCAMRWLAVRLDLISISLITTVALLIVLMHGHISP-----AYAGLALSYAVQLTGLFQF 1101

  Fly  1002 GMRQSAELENAMTSVERVLEY-KDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSP 1065
            .:|..:|.|...|||||:..| |:|:.||............|||.||::..:|:.:||.  ...|
Zfish  1102 TVRLLSETEARFTSVERINHYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYR--DGLP 1164

  Fly  1066 CVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLS-YNDGAILIDSLDTNDIGLHDLRSKISI 1129
            .|||.|.|:|.|.|.:|||||||:|||||..|||||: .:.|:|:||.::...|||.|||||:|:
Zfish  1165 LVLKNLCFSILPEETIGIVGRTGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSV 1229

  Fly  1130 IPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQL 1194
            ||||||||.||:|.||||::||.|.::|:|||..|:|:.:|:||:.|.|.:::.|.|||||:|||
Zfish  1230 IPQEPVLFIGTVRSNLDPWDQYTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQL 1294

  Fly  1195 VCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDA 1259
            :|:|||:||.::||::|||||.:|.:||.|||.|||:.|..||.|.|||||||::..::::|:|.
Zfish  1295 LCVARALLRHSKILLLDEATAAIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQ 1359

  Fly  1260 GHVVEFGSPYELLTASKAKVFHGMVMQTGKASF 1292
            |.::||.:|..|||...:: ||.| |:..:.:|
Zfish  1360 GQILEFDTPSNLLTDENSR-FHAM-MEAAEETF 1390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	455/1377 (33%)
		ABC_membrane	112..364	CDD:294371	79/267 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	89/198 (45%)
		ABC_membrane	736..955	CDD:294371	64/241 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	119/221 (54%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	461/1391 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920