DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc5

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1403	Identity:	467/1403 - (33%)
Similarity:	747/1403 - (53%)	Gaps:	186/1403 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCF--ALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCR 70
            :|.::||:.|.:.|.:  :|.:| ..:|..|...|:: .:::.|:..:......| ||:|: |.|
Zfish    94 HPVDNAGLFSFMTFNWLTSLAVL-AHKKGQLFLEDIW-AVSQFESCEINRRRLAGLWEEEI-RSR 155

  Fly    71 RKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQI 135
                 |...|:.||:......||::|.:.:...:|...:: |..:...:.|:::    .|.....
Zfish   156 -----GNDASLRRVVWHFCRTRLLLSILCLMVTQLAGFSS-PAFVVWRLLEYTQ----RSEPDLP 210

  Fly   136 YAVLLIACILASVLL---THPYMMGMMH-LAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNL 196
            |.:||:..:||:.|:   :|.....:.: ...::|.|:.:..:.|.|||  .||...:.|:::|:
Zfish   211 YGLLLVLGLLATELIRSWSHALTWALNYRTGTRLRGAILTMAFHKILRL--RSLREKSMGELINM 273

  Fly   197 LSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLR 261
            .|.|..|..........|..|||..::...:....:|..|..|.::.:|:.|...:.||:|:..|
Zfish   274 CSGDGQRMFEAAAVGSLLAGGPLVAVLGMAYNLFVLGPTSLLGSAVFILFYPTMMFSSRLTAYFR 338

  Fly   262 LQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLS---FE 323
            .:....|||||:.||||::.|:.||||.|.:.|.:.:.::|..|...:.:....:.|.:.   ..
Zfish   339 RKGVAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQSITVGVAPIV 403

  Fly   324 ITLGRIAIFVS--LLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRIT 386
            :.:..:|.|.:  |||:     :|||.:||.|...:|.:...: |..|..:...:|..|::.|..
Zfish   404 VVIASVATFSTHMLLGY-----DLTAAQAFTVVTVFNAMTFAL-KVTPFSVKSLSEASVAIDRFK 462

  Fly   387 NFMMREEANVI-----------DMS------------------------------ERRDEKA--- 407
            :.::..|..:|           :||                              :||....
Zfish   463 SLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTPHVGTRGCRKKRRQRDVPKH 527

  Fly   408 ----EEEQH--LLKEV--EKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQL 464
                |||.|  ||.:|  |..|.|      .|..:.:..:..|..:     .|:.:::|:::|:|
Zfish   528 HAILEEETHGQLLNDVSGEMASSP------KDQTLHVPTISQRLQR-----TLHCIDLSIQKGKL 581

  Fly   465 VAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYR 529
            |.|.|.|||||:|||.||||::....|:|.|.|.::|.:|:.|:.|||.|||||||..|:::||:
Zfish   582 VGVCGSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQ 646

  Fly   530 TVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVG 593
            .:|..|.|..||.:| .||.|.:|||||:||||||.||.||||:|....:|:|||||||:|.|||
Zfish   647 AILSACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVG 711

  Fly   594 RHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVEST 658
            .|:|:..::..|..:.||.||||||:|.|.|.:::|..|.::..|::|:::....|:|.:.   .
Zfish   712 NHIFNNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMF---N 773

  Fly   659 QNSGGGDEIITSPNLSRQSSALS---TKSSNGSSSSLESMVEKEKPKPSA---VSSQESRSGGQI 717
            ....|...||..|| .:..|:|.   .||..||       |:|||.....   :...|.|..|.:
Zfish   774 NLQLGETPIIEVPN-KKSGSSLKKPLEKSKAGS-------VKKEKSTTQGDGQLMQVEERGKGSV 830

  Fly   718 GLSMYKKYFGA--GCGVLVFVV-LIMLCIGTQILASGGDYFLSYWVKNTASSSTLDI-------- 771
            ..::||.|..|  |..|.:|:: |.:|.:|:...:   :::|.||:|..:.::|:.:
Zfish   831 PWAVYKVYIQALGGWPVFLFILALFILNVGSTAFS---NWWLCYWIKQGSGNTTVQVGNSSVLSE 892

  Fly   772 --------YYFTAI---NVG-LVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPS 824
                    .::.|:   ::| :::..|||.::|...|:.:|:.||:.:||.:.|:.:.||.|.|:
Zfish   893 SMRDNPLMQHYAAVYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPT 957

  Fly   825 GRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVL-CV-----TNPWYLINTFAMMLAFYY 883
            .||||||:.|:.:||..:|      .|..:....:|.|| |:     ..||:|:....::|.|..
Zfish   958 ARILNRFSKDMDEVDTRLP------FQAEMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTV 1016

  Fly   884 WRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFV 948
            .........|::|||:.|.:||..||.::::.||.|:.|.|.:...:.:|....|.:.:.:|.|.
Zfish  1017 LHVVSRVFIRELKRLDNVTQSPFLSHIASSIQGLTTVHAYGKEDEFLHRYQELLDQNQAPFYLFS 1081

  Fly   949 STSRAFGYYLDLFCVAYV-----ISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAE 1008
            ...|.....||:..||.:     :.|::|... ||.:    .||||:.|:.:||:.|:.:|.::|
Zfish  1082 CAMRWLAVRLDVISVALISITALMIVLMHGQI-PPAY----AGLAISYAVQLTGLFQFTVRLASE 1141

  Fly  1009 LENAMTSVERVLEY-KDLDPEGDFNSPA---EKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLK 1069
            .|...|||||:..| |.|..|    :||   .|.||..||:||::|.....::|.  .|.|.:||
Zfish  1142 TEARFTSVERIHHYIKSLSLE----APARVKNKAPPSDWPQEGEIVFDQTEMKYR--DNLPLILK 1200

  Fly  1070 GLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQE 1133
            ..|||::|.||:|||||||:|||||...|:|| ....|:|.||.::..||||.|:|||:||||||
Zfish  1201 KASFTVRPKEKIGIVGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIGLADVRSKLSIIPQE 1265

  Fly  1134 PVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLA 1198
            |||||||:|.|||||.||.:.::|.|||..|:||.:|:||..|:|.:.|.|.|||||:|||:|:|
Zfish  1266 PVLFSGTVRSNLDPFSQYSEAQIWDALERTHMKECVSQLPLKLESEVVENGENFSVGERQLLCVA 1330

  Fly  1199 RAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVV 1263
            |.:||:.:||::|||||.:..:||.|||.||||.|:|||.||||||::|::..|:::|::.|.||
Zfish  1331 RVLLRQCKILILDEATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTVLSCDRIMVLNQGQVV 1395

  Fly  1264 EFGSPYELLTASKAKVFHGMVMQTGKASFDHLLKVAEN 1301
            ||..|.:||....::             |..:|...||
Zfish  1396 EFDEPSKLLANENSR-------------FCAMLAAVEN 1420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	462/1373 (34%)
		ABC_membrane	112..364	CDD:294371	67/260 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/198 (47%)
		ABC_membrane	736..955	CDD:294371	64/245 (26%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	122/221 (55%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		12/56 (21%)
		CFTR_protein	95..1419	CDD:273530	465/1399 (33%)
		ABC_membrane	177..441	CDD:294371	68/275 (25%)
		nucleotide binding domain 1	188..248		11/64 (17%)
		transmembrane domain 2	279..379		30/99 (30%)
		nucleotide binding domain 2	403..450		14/52 (27%)
		ABCC_MRP_domain1	552..751	CDD:213217	95/203 (47%)
		ABC_membrane	851..1132	CDD:294371	79/294 (27%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	122/221 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820