DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc3

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_009304645.1	Gene:	abcc3 / 323301	ZFINID:	ZDB-GENE-050517-16	Length:	1540	Species:	Danio rerio

Alignment Length:	1398	Identity:	488/1398 - (34%)
Similarity:	742/1398 - (53%)	Gaps:	168/1398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LPPN--PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASL---GDEFFQGWEDE 65
            :.||  |..:||.||.:.|.:...:..||.|..|:..||: :||:::::.|   |  ....||.|
Zfish   198 MDPNVCPETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLW-SLNKNDSSELVVPG--LLNQWEVE 259

  Fly    66 VARCRRKGD-------------SG------------------------RKPSVLRVIGRVFG--- 90
            .::.....|             ||                        |:||.|..:.|.||
Zfish   260 KSKAHSSDDQNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFGPYF 324

  Fly    91 -----WRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLL 150
                 ::|:...||...         |.||..||: |::..:..|:.....|.|:....|...|:
Zfish   325 LIGSAFKLLQDLITFIN---------PQLLRMLIA-FTKQSDVPSWWGYALAFLMFGTSLLQTLI 379

  Fly   151 THPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLW 215
            .|.:........|::|..:..|||||||.::..:...:|.|:||||:|.|..||.......:.||
Zfish   380 LHQHFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLW 444

  Fly   216 LGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIIS 280
            ..||::.:|.:||::.:|.:...|::::||.:|...:::..|...:::.....|.|:::||||::
Zfish   445 SAPLQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILN 509

  Fly   281 GIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGI------LLSFEITLGRIAIFVSLLGFV 339
            ||:|:|:|.||..|...|.|:|:.|:..:|:...|..:      ...|.:.|...|:||:    |
Zfish   510 GIKVLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVN----V 570

  Fly   340 LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRD 404
            .....|.||:||...:.:||||..:: ..|..:|...:..||::|:.:|:..:|.:    .|..|
Zfish   571 DEKNVLDAEKAFVSLSLFNILRFPLN-MLPQVISSIVQASVSLKRLQDFLNHDELD----PESVD 630

  Fly   405 EKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIG 469
            .|:...::.:..|.        ||            ..|. ::..::|:|:|:.:.:|.|:||:|
Zfish   631 RKSNTTEYAVSVVN--------GK------------FSWA-KRDQVILDNINVLVPQGSLLAVVG 674

  Fly   470 PVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKR 534
            .||.||:|||.|:|||:....|.:.:.|..:|..|:.|:.||::|||||||.|..:|:||.||:.
Zfish   675 HVGCGKTSLISALLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEA 739

  Fly   535 CALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFD 598
            |||..|||:| .||.|.:||:|.:||||||.|:.||||:|..||||||||||||||.||.:|:||
Zfish   740 CALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFD 804

  Fly   599 ECM--RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL------- 654
            ..:  .|.|..:..|||||.:.||...:.|:::..|.||..|:|:::|:....||:.|
Zfish   805 HVIGPEGALKGKTRILVTHGISFLPQVNNILVLVDGRVSEMGSYQDLLRQNGAFAEFLRNYSLED 869

  Fly   655 -VESTQNSGGGDE----------------IITSP-------NLSRQSSALSTKSSNGSSSSL--- 692
             :|..:.:...||                :...|       ...||.|.:|....|....|.
Zfish   870 IIEDDELTVSFDEEEEEFPEDALSNHTDMVDNEPVVNEARRQFMRQMSIMSNDVENPKKMSRRRR 934

  Fly   693 -------ESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGA-GCGVLVFVVLIMLCIGTQILA 749
                   |:..||::||...:...|:...|::.|.:|.:|..| |..:.:|:..:..|  ....|
Zfish   935 CSERKHPETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGPLLALFICFLYGC--QSAAA 997

  Fly   750 SGGDYFLSYWVKNTASSST-------LDIYYFTAINVG---LVICALLRTLLFFNITMHSSTELH 804
            .|.:::||.|..:...:.|       :.:|....|:.|   |.||.|.|..    .|:.::...|
Zfish   998 IGANFWLSEWTNDALHNRTQEMLQTRVGVYAALGISQGVLILSICLLCRAY----STLRAARHTH 1058

  Fly   805 NTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPW 869
            ..|...:.|....||...||||:||||:.|:..:|.::|..:...::.|.....::.|..|..|.
Zfish  1059 QHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTIDSLIPDNIDIWMRTFWYTVNVLMVCSVLTPI 1123

  Fly   870 YLINTFAMMLAFYYW-RDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQY 933
            :||....:|| ||:| :.||:.|||.:||||:|:|||:|||||.::.|...|||.|.....:...
Zfish  1124 FLIVIVPLML-FYWWVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMS 1187

  Fly   934 DNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGM 998
            ||..|.:...||..:.::|..|..::......|:...|.........:.|.:||:::.||.:|..
Zfish  1188 DNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMS 1252

  Fly   999 VQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTN 1063
            :.|.:|.:::||:.:.:||||.||.:...|..: ...||:||..||..|.:...|.|:||....:
Zfish  1253 LNWMVRMTSDLESNIVAVERVKEYSETQTEAPW-EVLEKKPPPDWPPLGNVEFVDYSVRYREGLD 1316

  Fly  1064 SPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKI 1127
              .|||.:|..::..||:||||||||||||:...||| |....|.|:||.:..::|||||||||:
Zfish  1317 --LVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKL 1379

  Fly  1128 SIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQR 1192
            :||||||||||||:|.||||||:|.|:::|||||..||::.::...:.|:...||||.|.|||||
Zfish  1380 TIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGENLSVGQR 1444

  Fly  1193 QLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVM 1257
            ||||||||:||:.||||:|||||.||.:||.|||:|||.:|:||||.|||||||||||..:|||:
Zfish  1445 QLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVL 1509

  Fly  1258 DAGHVVEFGSPYELLTASKAKVFHGMVMQTGKA 1290
            |.|.:.||.:|..|:  ::..:|.||....|.|
Zfish  1510 DKGQIAEFDTPTNLM--NQKGLFFGMAKDAGLA 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	483/1379 (35%)
		ABC_membrane	112..364	CDD:294371	79/257 (31%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/200 (47%)
		ABC_membrane	736..955	CDD:294371	72/229 (31%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	131/221 (59%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	486/1395 (35%)
		ABC_membrane	330..595	CDD:279056	82/278 (29%)
		ABCC_MRP_domain1	640..841	CDD:213217	97/221 (44%)
		ABC_membrane	985..1253	CDD:279056	82/274 (30%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	131/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920