DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc10

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1339	Identity:	442/1339 - (33%)
Similarity:	677/1339 - (50%)	Gaps:	176/1339 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSSLMFCFALPILFKG-RKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGDSGRKPS 80
            ||...:.:..|:|.:| |.:..||.|..:.......|.|...|...|::....
  Rat   222 LSRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHWKEGAQL------------ 274

  Fly    81 VLRVIGRVFGWRLIMSGITIAALELGTRATV--------PLLLAGLISEFSEHGNGHSYNAQIYA 137
                      ||.:........:.||....|        ||||:.|:. |.|.|.....:..:|.
  Rat   275 ----------WRALYGAFGCCYIALGLLKMVGTMLGFSGPLLLSLLVG-FLEEGQEPLSHGLLYV 328

  Fly   138 VLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLN 202
            :.|.:..:.|.:|.:.|...:..:.::.||||.|.:|||.|:|..:.   ..||:|:|||..|..
  Rat   329 LGLASGSVISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLKLGPSR---PPTGEVLNLLGTDSE 390

  Fly   203 RFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYL-SRVTSKLRLQTAL 266
            |.......||..|..||:|.|..|.||||:|:|...|:.:.:|.:|:...: :|:.:  ..|..|
  Rat   391 RLLNFAGSFHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMA--NNQEML 453

  Fly   267 R-TDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIA 330
            | .|.||::|.|::|||:|:|.:.||:..|..:...|..|:..:|.:..|....:.....|..:.
  Rat   454 RHKDARVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVI 518

  Fly   331 IFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEAN 395
            ..|..:.:||.|.:|||.:.|...|..::|...::. ||..::...|..||:.||..|
  Rat   519 CIVIFITYVLLGHQLTATKVFTALALVHMLILPLNN-FPWVINGLLESKVSLDRIQRF------- 575

  Fly   396 VIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARW---GQEQHDLVLNNVNM 457
             :|:.....|              ..|......||.|::|:......|   |..|...:   .::
  Rat   576 -LDLPSYSPE--------------AYYSPDPPTEPSTVLELHEALFSWDPTGTSQKTFI---SHL 622

  Fly   458 SLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSG---KYSYASQEPWLFNASVRDNILF 519
            .:::|.||.::|.||.|||||:.||.|||....|.|.||.   .:..|:||||:..|::|||:||
  Rat   623 QVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDNVLF 687

  Fly   520 GLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDD 583
            |...|.|.||.||:.|||..||.:| .||.|.|||:|.:|||||||||.||||||:...:|||||
  Rat   688 GKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDD 752

  Fly   584 PLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQ 648
            ||:|||..|..||...|:.|.||....:|.||:.::||.|||:::|:.|.:...|...|:|...|
  Rat   753 PLAAVDADVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILPLVQ 817

  Fly   649 DFAQLLVESTQNSGGGDEIITSP---NLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQE 710
            .....|.:..|.:..|.    ||   ||.:.:..|.. :.|.|...::               :|
  Rat   818 AAPTALADKEQVTDSGQ----SPSVHNLEKTTEELDV-AQNTSGRLVQ---------------EE 862

  Fly   711 SRSGGQIGLSMYKKYF---GAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWV-----------K 761
            |:|.|.:.|.:|:.|:   |:|....:.:.|:::    |...:|.|::|::|:           :
  Rat   863 SKSEGAVALHVYRAYWRAMGSGLATAILISLLLM----QATRNGADWWLAHWLSQLKAGRNSSEE 923

  Fly   762 NTASSS------------------------------TLDIYYFTAINVGLV----ICALLRTLLF 792
            ..||||                              :.|::::..:...:.    :|.|||.:||
  Rat   924 RPASSSPRSMGFFSPRLLLFSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGVNSLCTLLRAVLF 988

  Fly   793 FNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLT 857
            ....:.::..||:.:...|....:.|:.:.||||:||||::|:..||:.:|.::...:...:.|.
  Rat   989 AAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLL 1053

  Fly   858 GIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRA 922
            |::.||....||.|:....:...:|..:..|..:.|:::||.::..||:|||.:.||.|||.:||
  Rat  1054 GLLAVLGSGLPWLLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRA 1118

  Fly   923 MGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYV-----ISVILHNFFNPPLHNA 982
            .||......:.....:|:....:...:|.:.....|.|...|.|     |:::.|   ...|.|.
  Rat  1119 AGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQH---QQGLANP 1180

  Fly   983 GQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYK-DL--DPEGDFNSPAEKQPPK--- 1041
            |.:||.::.||.:||::...:....:.|..|.||||:.||. |:  :|.|        |||:
  Rat  1181 GLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEPHG--------QPPQSPH 1237

  Fly  1042 ---SWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LS 1102
               ||..:|.:..:|:.|.|.|  ..|..|.|::|.::|.||:|||||||:|||||...||| |.
  Rat  1238 QRVSWLTQGSVEFQDVVLVYRP--GLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLE 1300

  Fly  1103 YNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKE 1167
            .:.|.:|:|.:||:.:.|.:|||::::|||||.|||||:|.||||...:.|..||:|||..|| .
  Rat  1301 PSAGQVLLDGVDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHL-S 1364

  Fly  1168 EISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNK 1232
            |::....||...:.|.|.:.|:|||||:|||||:|.:.:||.:|||||:||.:||.|:|.||..:
  Rat  1365 EVAMAIGGLDGELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRR 1429

  Fly  1233 FKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYEL 1271
            |.:.||||||||||||::||:|||:.||.|||..||..|
  Rat  1430 FANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSAL 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	442/1339 (33%)
		ABC_membrane	112..364	CDD:294371	80/253 (32%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/204 (47%)
		ABC_membrane	736..955	CDD:294371	61/263 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	115/221 (52%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	442/1339 (33%)
		ABC_membrane	290..552	CDD:294371	82/267 (31%)
		ABCC_MRP_domain1	599..802	CDD:213217	96/205 (47%)
		ABC_membrane	957..1190	CDD:294371	62/235 (26%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	25/82 (30%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	115/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740