DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_037172.2	Gene:	Abcc9 / 25560	RGDID:	3787	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1290	Identity:	406/1290 - (31%)
Similarity:	667/1290 - (51%)	Gaps:	111/1290 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RKPSVLRVIGRVFGWRLIMSGI--TIAALELGTRATVPLLLAGLISEFSEHGNGHS--------- 130
            |.||:...:.|.||..:::|..  .:|.| ||...  ||.::|::...:|..|..:
  Rat   281 RTPSIWLAMYRAFGRPILLSSTFRYLADL-LGFAG--PLCISGIVQRVNEPKNNTTRFSETLSSK 342

  Fly   131 ---YNAQIYAVLL-IACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTT 189
               .||.:.|||| :|.||....|...|.: .:...:.:|.|:.:.||.|.||||.:  |:|..|
  Rat   343 EFLENAHVLAVLLFLALILQRTFLQASYYV-TIETGINLRGALLAMIYNKILRLSTSNLSMGEMT 406

  Fly   190 TGQVVNLLSNDLNRFDRCLIHFHF----LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQ 250
            .||:.||::.:.|:    |:.|.|    ||..|:::::....||..:|.::..|.:::||..|:|
  Rat   407 LGQINNLVAIETNQ----LMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 467

  Fly   251 TYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLL 315
            .:::...::.:..|...:.:|::..|||:.||:::|:|.||..|.|.:.:.|..|:||::...|.
  Rat   468 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALY 532

  Fly   316 RGILLSFEITLGRIAIFVSLLGFV-LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFA-EL 378
            ..:.:.....:...|:..:.:... ..|..|....||...:.::||  ....|..|.:.:|| :.
  Rat   533 TSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL--VTPLFLLSTVVRFAVKA 595

  Fly   379 LVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEP-----DTLVEIKA 438
            ::|::::..|::.:|  :.:.|.|..|.....:...|....:|.|:. .|:|     |...:.:.
  Rat   596 IISVQKLNEFLLSDE--IGEDSWRTGEGTLPFESCKKHTGVQSKPIN-RKQPGRYHLDNYEQARR 657

  Fly   439 LRA---------------RWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPP 488
            ||.               .||...  ..|:|:::.:..|||..::|.||.|||||:.|||||:..
  Rat   658 LRPAETEDVAIKVTNGYFSWGSGL--ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQT 720

  Fly   489 ESGSV---------------QVSGKYS--YASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCA 536
            ..|.|               :...:||  ||:|:|||.||:|.:||.||...::|||:.|...|:
  Rat   721 LEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQRYKAVTDACS 785

  Fly   537 LERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDEC 600
            |:.|::|| .||.|.:||||.:||||||.|||:|||:|:..::..||||.||:|.|:..||..|.
  Rat   786 LQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEG 850

  Fly   601 MRGFL--GKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGG 663
            :..||  .|:.|:||||:||:|..||.|:.|..|.|...||    ||..|.....|.|..:....
  Rat   851 ILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGT----LKDIQTKDVELYEHWKTLMN 911

  Fly   664 GDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKK---- 724
            ..:.....::....:.|..|:...:..|.|:..:.|.........::........:.:..|
  Rat   912 RQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWK 976

  Fly   725 ----YFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLD------IYYFTAINV 779
                |..:|...|:|:::....:...::.: .||:|:.|   |:..|..|      .:|....::
  Rat   977 TCWWYLTSGGFFLLFLMIFSKLLKHSVIVA-IDYWLATW---TSEYSINDPGKADQTFYVAGFSI 1037

  Fly   780 ----GLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDE 840
                |:.:| |:.:|....:.:.::..||:.:...:....:.||.|.|.|.|||||:.|...:|:
  Rat  1038 LCGAGIFLC-LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQ 1101

  Fly   841 VMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSP 905
            .:|..:....:..|.....|.::....|.:||....:.:|||:.:.::...|:|::.|:...:.|
  Rat  1102 HIPPTLESLTRSTLLCLSAIGMISYATPVFLIALAPLGVAFYFIQKYFRVASKDLQELDDSTQLP 1166

  Fly   906 MYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVI 970
            :..|||.|..||.||||...:.....:.....|.::..|....:.:|......|......|::..
  Rat  1167 LLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTAS 1231

  Fly   971 LHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA 1035
            :.:....  .|:|.:||.:..||.:|..:.|.:|..|:||..|.:|::|..:..::.|....:..
  Rat  1232 IASISGS--SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMD 1294

  Fly  1036 EKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR 1100
            ..|.|:.||:||::...||.:|||  .|...|||.:...|:|.:||||.||||:|||||..|.||
  Rat  1295 PSQVPEHWPQEGEIKIHDLCVRYE--NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFR 1357

  Fly  1101 L-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVH 1164
            : ...||.|:||.:|.:.:.||.|||::|||.|:|:||||::|:||||..:..||:||:|||...
  Rat  1358 MVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQ 1422

  Fly  1165 LKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATI 1229
            ||..:..||.||.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:.::|..:
  Rat  1423 LKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVV 1487

  Fly  1230 RNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMV 1284
            ...|.|.||:|||||::||:.:|.|:||..|:::|:.:| |.|.|.:..||...|
  Rat  1488 MTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ESLLAQEDGVFASFV 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	401/1277 (31%)
		ABC_membrane	112..364	CDD:294371	72/271 (27%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/232 (41%)
		ABC_membrane	736..955	CDD:294371	52/228 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	112/221 (51%)
Abcc9	NP_037172.2	MRP_assoc_pro	222..1542	CDD:188098	406/1290 (31%)
Abcc9	NP_037172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..963		2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810