DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31793 and Abcc8

DIOPT Version :9

Sequence 1:NP_609930.4 Gene:CG31793 / 326161 FlyBaseID:FBgn0051793 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_037171.2 Gene:Abcc8 / 25559 RGDID:3786 Length:1582 Species:Rattus norvegicus


Alignment Length:1458 Identity:433/1458 - (29%)
Similarity:706/1458 - (48%) Gaps:276/1458 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 ILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQ-----------GWEDEVARCRRKGDSGRKPSV 81
            :.||..::...|.||         ..||..|.|           .|.:...:...|     ||..
  Rat   196 VFFKTPREVKPPEDL---------QDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHK-----KPID 246

  Fly    82 LRVIGRV-----------------------------------------FGWRLIMSG-ITIAALE 104
            ||.||::                                         ||.||::|. ..|.|..
  Rat   247 LRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADL 311

  Fly   105 LGTRATVPLLLAGLISEFSEHGNGHSY-------------------NAQIYAVLL-IACILASVL 149
            ||...  ||.:.|::....:  ..|.:                   ||.:.|||| :|.:|....
  Rat   312 LGFAG--PLCIFGIVDHLGK--ENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTF 372

  Fly   150 LTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFH 212
            |...|.:. :...:.:|.|:.:.||.|.:.||.:  |:|..|.||:.||::.|.|:    |:.|.
  Rat   373 LQASYYVA-IETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQ----LMWFF 432

  Fly   213 F----LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVR 273
            |    ||..|:::::....||..:|:::..|.::::|..|:|.:::...|:.:..|...:::|::
  Rat   433 FLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLK 497

  Fly   274 MMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGF 338
            ..||::.||:::|:|.||..|...:.:.||.||:|:|...:...|.:.....:...|:.::.:|.
  Rat   498 QTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGH 562

  Fly   339 V--LGGGELTAERAFCVTAFYNILRRTVSKFF--PSGMSQFAELLVSMRRITNFM----MREE-- 393
            |  ....:.:...||...:.::||   |:..|  .|.:....:.|||:::::.|:    :|||  
  Rat   563 VSFFKESDFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC 624

  Fly   394 ---------------ANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARW 443
                           |..:.:..|:....||.:.||..:: |..|...|...:..|:|......|
  Rat   625 APREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQ-RLTPSTDGDADNFCVQIIGGFFTW 688

  Fly   444 GQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSV--------------- 493
            ..:... .|:|:.:.:.||||..::|.||.|||||:.|.|||:...||:|               
  Rat   689 TPDGIP-TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGEDPS 752

  Fly   494 ------------QVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-H 545
                        :..|..:||||:|||.||:|.:||.|..|.:||||:.|::.|:|:.|:::| |
  Rat   753 NPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPH 817

  Fly   546 GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFD----ECMRGFLG 606
            ||.|.:||||.:||||||.||.:|||:|:..:|..||||.||:|.|:..||..    |.:|.  .
  Rat   818 GDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRD--D 880

  Fly   607 KQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSP 671
            |:.|:||||:||:|..||.|:.|..|.:...||.::..:|.   .||...            ...
  Rat   881 KRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQLFEH------------WKT 930

  Fly   672 NLSRQSSALSTKSSNGSSSSLESMVEKEKPKPS-----AVSSQ---------------ESRSGGQ 716
            .::||...|..          |:::|::.|:||     |:||:               ||.....
  Rat   931 LMNRQDQELEK----------ETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDN 985

  Fly   717 IGLSMYK----------KYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW----------VK 761
            :...:::          ||. :..|:|:..:|:...:...::....||:|:.|          .:
  Rat   986 LSSVLHQRAKIPWRACTKYL-SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAAR 1049

  Fly   762 NTASSS--TLD--IY--YFTAI-NVGLVICALLRTLLFFNIT-----MHSSTELHNTMFQGLSRT 814
            |.:.|.  .||  :|  .||.: ::|:.:|      |..::|     :..:..||.::...:...
  Rat  1050 NCSLSQECALDQSVYAMVFTVLCSLGIALC------LVTSVTVEWTGLKVAKRLHRSLLNRIILA 1108

  Fly   815 ALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCI-QIFLTLTGIICVLCVTNPWYLINTFAMM 878
            .:.||.|.|.|.|||||::|...:|:.:|:. |:|: :..|.....:.|:....|.:|:....:.
  Rat  1109 PMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVSALAVISYVTPVFLVALLPLA 1172

  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAM----GAQQTLIGQYDNYQDL 939
            :..|:.:.::...|||:::|:...:.|:.|||:.|:.||.||||.    ..||.|:    .|.|.
  Rat  1173 VVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLL----EYTDS 1233

  Fly   940 HSSGYYTFVSTSR-------AFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTG 997
            ::.......:.:|       ..|..:.|...|..||..||...     :||.:||.:|.||.::.
  Rat  1234 NNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHREL-----SAGLVGLGLTYALMVSN 1293

  Fly   998 MVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDT 1062
            .:.|.:|..|::|..:.:|:|:......:.|......|....||:||.:||:..::||:||  |:
  Rat  1294 YLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DS 1356

  Fly  1063 NSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSK 1126
            :...|||.::..|.|.:|:||.||||:||||...|.||: ...:|.|:||.:|...:.||.|||:
  Rat  1357 SLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSR 1421

  Fly  1127 ISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQ 1191
            :|||.|:|||||||:|:||||.::..|..||:|||...||..:..||.||.:||:|||.|||.||
  Rat  1422 LSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQ 1486

  Fly  1192 RQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLV 1256
            |||.|||||.:|:..|.:||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.|:|
  Rat  1487 RQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMV 1551

  Fly  1257 MDAGHVVEFGSPYELLTASKAKVFHGMV 1284
            :..|.::||..|.:|| :.|..||...|
  Rat  1552 LKRGAILEFDKPEKLL-SQKDSVFASFV 1578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31793NP_609930.4 CFTR_protein 1..1273 CDD:273530 428/1445 (30%)
ABC_membrane 112..364 CDD:294371 69/279 (25%)
ABCC_MRP_domain1 434..632 CDD:213217 94/229 (41%)
ABC_membrane 736..955 CDD:294371 59/252 (23%)
ABCC_MRP_domain2 1047..1268 CDD:213211 110/221 (50%)
Abcc8NP_037171.2 CFTR_protein 223..1582 CDD:273530 424/1422 (30%)
ABC_membrane <375..590 CDD:279056 57/222 (26%)
P-loop_NTPase 679..907 CDD:304359 94/230 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..768 0/26 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..962 7/32 (22%)
ABC_membrane 1017..1295 CDD:279056 72/293 (25%)
ABCC_SUR2 1343..1582 CDD:213255 117/239 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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