DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abc2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_593943.3	Gene:	abc2 / 2543193	PomBaseID:	SPAC3F10.11c	Length:	1478	Species:	Schizosaccharomyces pombe

Alignment Length:	1353	Identity:	461/1353 - (34%)
Similarity:	720/1353 - (53%)	Gaps:	123/1353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQASKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDE 65
            ::.:.|.|:....|.|.|.:.|.:..|::..|.:..|..:|.:.......:::|...|.:.|
pombe   182 LEETGLRPSRFTYANIFSRISFGWLSPLMKFGYRNYLTESDAWSLPPAERSSNLTIVFEKNW--- 243

  Fly    66 VARCRRKGDSGRKPSVLRVIGRVF--GWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNG 128
            ::..::|..|      |.:.|.:|  .|:|.:..|.:..::.......|.|:..::...|.:.:.
pombe   244 ISHAKKKKSS------LYMWGVLFLNHWKLTVVIIVLKLVQDVVAFIQPNLIRKIVIFVSSYSSE 302

  Fly   129 HSYNAQIYAVLLIACILASV----LLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTT 189
            |....|:...|.||..|.:|    ||...:.:||: |.|:.|..:.:|||||:||||..:....:
pombe   303 HPQPPQVGFSLAIAMFLTNVVQTALLQQYFQLGMV-LGMRWRSELITAIYRKSLRLSSAARQSRS 366

  Fly   190 TGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLS 254
            .|.:||.:|.|..:.....:....:..||.::::|...||..:|..:..|..:..|..|....::
pombe   367 VGDIVNYMSVDTQKVCDLTMFLFVIVSGPFQIVLALTNLYHLVGYGALSGAFVTFLLFPCNVVIA 431

  Fly   255 RVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGIL 319
            .:..:.:.:.....|.|.:.|.|||:.|:.||:|.||..|.:.:.|:|.:     |::.:|:.|
pombe   432 SIFKRFQNRQMKNKDARSQFMTEIINNIRSIKLYAWENIFLQKLLQLRNT-----RELRMLKKI- 490

  Fly   320 LSFEITLGRIA-----IFVSLLGF----VLGGGE--LTAERAFCVTAFYNILRRTVSKFFPSGMS 373
             ....|:|...     |.||...|    ||.|..  |:.:..|...:.:|:|:..:: ..|..:|
pombe   491 -GIVNTIGNFTWLFAPILVSAATFGTFIVLYGKTRVLSVDIVFACLSLFNLLQFPLT-MLPIVVS 553

  Fly   374 QFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPD-TLVEIK 437
            ...|..|::.||..|:...|.         |..|.:.           ||.  .|||. ..:|||
pombe   554 SVLEASVAISRIYGFLTAGEL---------DSNAVQR-----------YPA--NKEPSGVCLEIK 596

  Fly   438 ALRARW---GQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKY 499
            .....|   ||...:..|.:::...|||:|..::|.||.|||||::|.||.:...||||...|..
pombe   597 KGTFSWSGPGQNAAEPTLRDIDFVARRGELCCIVGKVGMGKSSLLEACLGNMQKHSGSVFRCGSI 661

  Fly   500 SYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQR 563
            :||:|:||:.||::::||||||.:|.:.|...::.|.|.||.|:| .||.|.|||:|.||||||:
pombe   662 AYAAQQPWILNATIQENILFGLELDPEFYEKTIRACCLLRDFEILADGDQTEVGEKGISLSGGQK 726

  Fly   564 ARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLEDADLI 626
            |||.||||||.|:|:|||||.|||||.||.|.|....:  :|.|..:.|||.|:.|..|::|.:|
pombe   727 ARISLARAVYSRSDIYLLDDILSAVDQHVNRDLVRNLLGSKGLLRSRCVILSTNSLTVLKEASMI 791

  Fly   627 VIMDKGHVSACGTYEEMLKS-GQDFAQLLVE----STQNSGGGDEIITSPNLSRQSSALSTKSSN 686
            .::..|.:...|::.::..| .....|||.|    .|.:|.|.|    :| |||..|.:::.:..
pombe   792 YMLRNGKIIESGSFTQLSSSPDSQLFQLLSEFSKKDTASSTGAD----TP-LSRSQSVITSSTDV 851

  Fly   687 GSSSSLESMVEKEKPK-------------------PSAVSSQESRSGGQIGLSMYKKYFGAGCGV 732
            .||:|..|......||                   .:...:.|....|::...:|..||.| |.:
pombe   852 TSSASRSSDTVSNYPKATIKGTGRIRKRLTDEDNVKATGQAAEKMERGKVKWKVYWTYFKA-CSL 915

  Fly   733 LVFVVLIMLCIGTQILASGGDYFLSYWVK-NTASSSTLDIYYFTAINV--GLVICALLRTLLFFN 794
            .:..:..:..||...:..|.:.:|.:|.: ||........|::..|..  ||:.|||: :|....
pombe   916 FLIFLYFLFIIGGIGMNVGTNVWLKHWSEVNTQLGYNPKPYFYLGIYTLFGLLSCALI-SLSSLT 979

  Fly   795 IT----MHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLT 855
            ||    :.|...||::|.:.:.|..:.||.|.|:|||||||::|:.:||||:..|.:...:....
pombe   980 ITVFCAIKSCRYLHDSMVKAVLRAPMSFFETTPTGRILNRFSSDVYRVDEVISRVFMFFFRNLFQ 1044

  Fly   856 LTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTI 920
            :..::.|:|.::|.::|....:...:.|.:.:|.:|||::|||::|.|||:|:||..:|.||.||
pombe  1045 IVFVLAVICYSSPMFMILIVPLFFLYRYNQVYYTQTSRELKRLDSVTRSPLYAHFQESLGGLSTI 1109

  Fly   921 RAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSR-------AFGYYLDLFCVAY--VISVILHNFFN 976
            ||...:.|.|.:.|...|.:...::.:.|::|       |.| .|.:|..|:  |:|.:..|
pombe  1110 RAYDMEDTFISENDIRVDTNHRIWFLYFSSNRWQAIRVEAIG-ALVVFSSAFFGVLSAVRGN--- 1170

  Fly   977 PPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPK 1041
               .|:|.:||:::.|:.:|..:.:.:|||.::|..:.||||:|||..|..|.....| :.:||:
pombe  1171 ---PNSGLVGLSLSYAVQITQSLTFVVRQSVDVETNIVSVERMLEYIGLPSEAPSIIP-DHRPPE 1231

  Fly  1042 SWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYND 1105
            .||..|.:.....|:||.  .|.|.||..:|..|:|.||:|||||||||||:|..||||| ....
pombe  1232 GWPSHGAIKFDHYSVRYR--ENLPLVLNDISVNIKPQEKIGIVGRTGAGKSTLTLALFRLIEPTS 1294

  Fly  1106 GAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEIS 1170
            |.|.:|.::...||||||||:::|||||...|.||:|.||||.....|:::|.|||...||:.|.
pombe  1295 GDIQLDDINITSIGLHDLRSRLAIIPQENQAFEGTIRENLDPNANATDEEIWHALEAASLKQFIQ 1359

  Fly  1171 ELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKD 1235
            .|..||.|.::|||.|.|.|||||:||.||:|...|:|::|||||.||.:|||::|.|||.:|.|
pombe  1360 TLDGGLYSRVTEGGANLSSGQRQLMCLTRALLTPTRVLLLDEATAAVDVETDAIVQRTIRERFND 1424

  Fly  1236 CTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            .|:||||||:||:|||:::||:|.|.||||.|..:|| .:||.:|:.:..::|
pombe  1425 RTILTIAHRINTVMDSNRILVLDHGKVVEFDSTKKLL-ENKASLFYSLAKESG 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	456/1336 (34%)
		ABC_membrane	112..364	CDD:294371	71/266 (27%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/203 (47%)
		ABC_membrane	736..955	CDD:294371	72/232 (31%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	119/221 (54%)
abc2	NP_593943.3	MRP_assoc_pro	96..1477	CDD:188098	461/1353 (34%)
		ABC_membrane	272..545	CDD:279056	72/280 (26%)
		ABCC_MRP_domain1	593..798	CDD:213217	96/204 (47%)
		ABC_membrane	928..1190	CDD:279056	83/269 (31%)
		ABCC_MRP_domain2	1237..1456	CDD:213211	119/220 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810