DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abc4

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1318	Identity:	390/1318 - (29%)
Similarity:	642/1318 - (48%)	Gaps:	165/1318 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MFCFAL------PILFKGRKQTLQ--PTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGDSGR 77
            ||.||.      |::...:::.::  .|.:....::::|          |.....|.       :
pombe   233 MFNFACSYGYLNPLVLTAKRRVVEVDDTPVIPDYDKNKA----------WTYRFERM-------K 280

  Fly    78 KPSVLRVIGRVFGWRLIMSGITIAALELGT-RATVPLLLAGLISEFSEHGNGHSYNAQIYAVLLI 141
            .||:...|.::| ||.|: |:.:::..:.. :...|:.|..|:... |..:..|.|..::.|||:
pombe   281 TPSLFITIHKIF-WRQIL-GMGVSSFMVSVCQFLSPIALNRLLKHL-ESPSSSSVNPLVWIVLLL 342

  Fly   142 ACILASVLLTHPYM-MGMMHLAMKMRVAVSSAIYRKAL--RLSRTSLGGTTTGQVVNLLSNDLNR 203
            .....:.|.|..|: |...:||......|.. ||.|.:  |..:...|.:..|:..||:|.|::.
pombe   343 TGPFLTSLFTQFYLFMSTRYLARSYTTLVQQ-IYNKVIRSRFVQNKSGDSKVGRSNNLISTDVDD 406

  Fly   204 FDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRT 268
            ........|.:...|:|:..:.|.|.:.:|.:::.|:::.||...:...|..:.:||.|:....|
pombe   407 IGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLRANRAT 471

  Fly   269 DQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFV 333
            |.|:.:|:|::..|::.|.:.||.|....:.|.|:.|::...::.|:.   :..::.:..:.:|.
pombe   472 DSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLME---ICIQVLVESLPVFS 533

  Fly   334 SLLGFV----LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEA 394
            ....||    :.|..:|...||...:.::.: ||...:....|.|..::.||:.|:::|:
pombe   534 MFATFVVFTTIMGQTITPSIAFTSISLFSFI-RTQFSWIAYLMRQIVQIFVSIGRVSDFL----- 592

  Fly   395 NVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSL 459
                       ...:|...:..:|..|..:|......|.|.        .....|..|.::|:..
pombe   593 -----------NDPDEVDPVNTIEDTSQEIGFFNASLTWVS--------NPSPGDFCLRDLNIVF 638

  Fly   460 RRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQV--SGKYSYASQEPWLFNASVRDNILFGLP 522
            .|.:|..||||.||||||||.|:||||....||..:  |...||.||.|||.||::||||||..|
pombe   639 PRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYP 703

  Fly   523 MDKQRYRTVLKRCALERDLE-LLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLS 586
            ..::||:.|::.|.|..||: .:..|.|.:||:|.:|||||:.||.||||||....:.|:||..|
pombe   704 YIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFS 768

  Fly   587 AVDTHVGRHLFDECMR-GFLGKQLVILVTHQLQ-FLEDADLIVIMDKGHVSACGTYEEMLKSGQD 649
            |:|.|....::..|.: ..:..:.||||||.:. |::.|..||               .:|:|..
pombe   769 ALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIV---------------TVKNGSA 818

  Fly   650 FAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESM--------VEKEKPKPSAV 706
            |     ..|..|        ||.|.....|.|  :|..::..|.::        .|....|...:
pombe   819 F-----PVTDKS--------SPLLFLAEQAAS--ASEAAAPDLAAIPIPNEVDDAEAADEKDGKL 868

  Fly   707 SSQESRSGGQIGLS---MYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSST 768
            ..:|.|..|.:..|   .|.|:||:|..|...::..:....|.||.   |.::::|..::.:|..
pombe   869 VEEEQRVTGDVVFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILI---DLWVAFWTNSSVNSPD 930

  Fly   769 LD----IYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILN 829
            ::    ::.:..:.:...:...|||:.:......:|.:||::|.:.:..|...:|...|:|||:|
pombe   931 VNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESVFGTFASWFDKTPTGRIVN 995

  Fly   830 RFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRD 894
            |||.|:..:|..:...:...|..||::.|.|..:....|.::|....:.||.||:...|.:....
pombe   996 RFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVIVCLAGYYFGLLYTRAQVG 1060

  Fly   895 VKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQ-----YDNYQDLHSSGY----YTFVST 950
            ||||.::..||::|....::||:..|||.. :||:..|     .||...|.|:.|    :..|.|
pombe  1061 VKRLISIYTSPIFSLLGESIVGVSVIRAFN-RQTIFKQMFSERLDNLVRLQSTSYNLNRWVAVRT 1124

  Fly   951 SRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTS 1015
            ....|.   :..:|.:|: :|....:|     |.:|.::.||:..:..|...:|....|:..|.|
pombe  1125 DGISGL---VGAIAGLIA-LLQKDLSP-----GVVGFSLNQAVIFSSSVLLFVRSCNSLQAEMNS 1180

  Fly  1016 VERVLEYKDLDPEGDFNSPAEK---QPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQP 1077
            .||||||..|..|     ||..   |.|.:|||||.:|...:|:.|  ....|.:||.::..|.|
pombe  1181 YERVLEYSKLPQE-----PAPTIAGQVPATWPKEGDIVFNHVSVSY--SAAGPTILKDVNLHINP 1238

  Fly  1078 MEKVGIVGRTGAGKSSLINALFRLSYN-DGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTM 1141
            .|||.:|||||:|||:|...|.|.::. .|.|.|:..:|..:.|:.||.:||.|||:|:|||||:
pombe  1239 SEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQDPILFSGTV 1303

  Fly  1142 RYNLDPFEQYPDDKLWKALED--------VHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLA 1198
            |.|||||::..|:.|.:||:.        .|..:: ..:...|.:.::..|:|||.||:|::.||
pombe  1304 RSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQ-KPIHITLDTHVASEGSNFSQGQKQVLALA 1367

  Fly  1199 RAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVV 1263
            |||:|.::|:::||.||:||...|..||.|:|..|.|.|:|.|||||.||:|.|||:|:|.|.:|
pombe  1368 RAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVMVLDKGVLV 1432

  Fly  1264 EFGSPYELLTASKAKVFH 1281
            |:|.|        |.::|
pombe  1433 EYGPP--------AVLYH 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	388/1308 (30%)
		ABC_membrane	112..364	CDD:294371	61/258 (24%)
		ABCC_MRP_domain1	434..632	CDD:213217	85/202 (42%)
		ABC_membrane	736..955	CDD:294371	59/231 (26%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	99/229 (43%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	386/1311 (29%)
		ABC_membrane	300..568	CDD:294371	62/273 (23%)
		ABCC_MRP_domain1	611..817	CDD:213217	88/228 (39%)
		ABC_membrane	901..1164	CDD:294371	68/275 (25%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	99/229 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900