DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abc3

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1359	Identity:	444/1359 - (32%)
Similarity:	707/1359 - (52%)	Gaps:	144/1359 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASL--GDEFFQGWEDEVARCR 70
            |:....|.|.|.|.|.:....:..|....|:.:|::....:..:.:|  |   |:.|....::.:
pombe   171 PSEVRYANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERSGNLIIG---FEDWWIYHSKNK 232

  Fly    71 RKGDSGRKPSVLRVIGRVFGWRL-------IMSGITIAALELGTRATV-PLLLAG---LISEFSE 124
            |:.              :|.|:|       :::.|||..|.....|.| |.|:..   .||.::.
pombe   233 RRS--------------LFLWKLLFFNHWKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTS 283

  Fly   125 HGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTT 189
            ..........|.|:|::.......||...|...:|.|.|:.:..:.::||||:|.||.::....:
pombe   284 PNPESPSRGFIIAILVLVANFLQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLLLSSSARQNRS 348

  Fly   190 TGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLS 254
            .|.::|.::.|..:.....|:...:..||.::.:|...||..:|.::|.|::..|:..|....::
pombe   349 IGDIINYMAVDTQKISDLPIYLFIIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFPCNIIVA 413

  Fly   255 RVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPF-GKLIGQMRRSEMSSIRQMNLLRGI 318
            .|..|.:.......|.|.::|.|||:.|:.||:|.||.|| .||:......|:|.:::
pombe   414 NVYKKFQSILMKNKDSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELSMLKK------- 471

  Fly   319 LLSFEITLGRIA-IFVSLL-------GFVLGGGE---LTAERAFCVTAFYNILRRTVSKFFPSGM 372
             :.|...:|..| ||.:::       .|::..|:   |||:..|...:.:|:|:..:: ..|:.:
pombe   472 -IGFITAIGDFAWIFTTIIVTTVAFGAFIIFHGKTQALTADIVFPAVSLFNLLQFPLA-MLPTVI 534

  Fly   373 SQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIK 437
            |...|..||:.||..|::.:|   :|.:..:...|.|..|                  :..:|||
pombe   535 SSLLEASVSVSRIYEFLIAQE---LDYNGVQRFPATEIPH------------------EICLEIK 578

  Fly   438 ALRARWG----QEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGK 498
            :....|.    ::|....|..:|...:.|:|..:.|.||:|||||::|.:|.:...||||...|.
pombe   579 SGTFSWSKKTLKQQVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGS 643

  Fly   499 YSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQ 562
            .:||:|:||:|:|::|:|||||...|.:.|...:..|.|:||.|:. .||.|.||::||||||||
pombe   644 LAYAAQQPWIFDATIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQ 708

  Fly   563 RARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLEDADL 625
            ::||.||||:|.:||:|||||.||:||.||.|.|.....  .|||....|:|.|:.|..|::||.
pombe   709 KSRISLARAIYSQADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKEADS 773

  Fly   626 IVIMDKGHVSACGTYEEM-LKSGQDFAQLLVE-----STQ------NSGGGDEIITSPN-----L 673
            |.|:..|.:...|.||.: :.:..:..|.|.|     .||      .|....:|..:|:     |
pombe   774 IYILSNGKIVEKGNYEHLFVSTNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVEGL 838

  Fly   674 SRQSSALSTKSSNGSSSS-----LESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVL 733
            ...||:....|||...|.     .:.:.|.:|.| ....:.|....|::...:|..|| ..|.:.
pombe   839 ETYSSSERKDSSNKYKSRKRNPIRQKVTEDDKGK-CVAQTDELVQRGKVKWHVYWMYF-KSCSIG 901

  Fly   734 VFVVLIMLCIGTQILASGGDYFLSYWVKNTASSST---------LDIYYFTAINVGLVICALLRT 789
            :.::.....|...::....:.:|.:|.:....||:         |.||.|    .|.:.||.:.:
pombe   902 LILLYFFFIISGIMMNVATNVWLKHWSEENGKSSSELNPSPYFYLGIYLF----FGFLSCAFISS 962

  Fly   790 LLFFNITM------HSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLD 848
               .::||      .|...||::|.:.:.|..:.||.|..||||||||:||:.:||||:....:.
pombe   963 ---SSLTMTVLCGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYKVDEVVSLTFMF 1024

  Fly   849 CIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSAT 913
            ..:..:.:..|:.|:|.:.|..|:....:...:.|.|.:|::|||::|||:.|.|||:|:|...:
pombe  1025 FFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYLYNRAYYVRTSRELKRLDNVTRSPLYAHVQES 1089

  Fly   914 LVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLD------LFCVAY--VISVI 970
            |.||.||||.|.|:|.:.:.|...|.:...::.|.|:||.....::      :||.|:  ::|.|
pombe  1090 LSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQAIRVECIGDLIIFCTAFYGILSAI 1154

  Fly   971 LHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA 1035
            ..:      .|.|.:|.:::.|:.:|..:.:.::||.:.||...||||:|||.::..|.....|
pombe  1155 KGS------PNPGLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVERILEYINVKSEAPEIIP- 1212

  Fly  1036 EKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR 1100
            |.:||..||.:|.:.....|.:|..|.:  ..|..::..|.|.||:|||||||||||:|..||||
pombe  1213 ENRPPCEWPTDGAVSFNHYSAKYREDLS--FALNNINIEISPREKIGIVGRTGAGKSTLAMALFR 1275

  Fly  1101 -LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVH 1164
             :...:|.|.||:.|....||:||||::||||||..:|.|.:|.||||..:..|.|:|:.||...
pombe  1276 IIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIWEVLEIAS 1340

  Fly  1165 LKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATI 1229
            ||..||:|..||.|.::|||.|||.|||||:||||.:|...|||::|||||:|..:|||::|.||
pombe  1341 LKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETDAIVQQTI 1405

  Fly  1230 RNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            |.:|||.|:||:|||:||:||||::||:|.|.||||.:..:|| .:|..:|:.:..::|
pombe  1406 RKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKLL-ENKDSMFYSLAKESG 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	440/1342 (33%)
		ABC_membrane	112..364	CDD:294371	67/266 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	91/204 (45%)
		ABC_membrane	736..955	CDD:294371	72/233 (31%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	117/221 (53%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	444/1359 (33%)
		ABC_membrane	254..527	CDD:294371	72/280 (26%)
		ABCC_MRP_domain1	575..781	CDD:213217	91/205 (44%)
		ABC_membrane	907..1177	CDD:279056	82/282 (29%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	117/220 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I894
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810