DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	462/1406 - (32%)
Similarity:	741/1406 - (52%)	Gaps:	181/1406 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDL------YKT---LNEHEAASLGD-----EFFQ 60
            |..:|..|||:.|.:....:.||.|..|...|:      :||   .::.|||...|     :.||
  Rat   193 PSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQ 257

  Fly    61 GWEDEVARCRRKGDSGRKPS-------------------------------------VLRVIGRV 88
                     ||...|.|||.                                     :::.:.:.
  Rat   258 ---------RRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKT 313

  Fly    89 FGWRLIMSGITIAALELGTRATV---PLLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLL 150
            |...::.|.|    |:|.....|   |.||..||. |.:..|.:.:...|.|:|:.|..|.....
  Rat   314 FHVVILKSFI----LKLIHDLLVFLNPQLLKLLIG-FVKSSNSYVWFGYICAILMFAVTLIQSFC 373

  Fly   151 THPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLW 215
            ...|......|.|.:|..|.|:||:|||.||..:....|.|:.|||:|.|..:......:...:|
  Rat   374 LQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVW 438

  Fly   216 LGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIIS 280
            ...:::.::.:||:.::|.:...|:.::||.:|:...|:.....:::|.....|:|:::||||:|
  Rat   439 SSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILS 503

  Fly   281 GIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILL-SFEITLGRIAIFVSLLGF-----V 339
            ||:::|.:.||..|.:.:..:|:.|:.::.:...|:.:|: ..:||    .|.||::.|     |
  Rat   504 GIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQIT----PILVSVVTFSVYVLV 564

  Fly   340 LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRD 404
            .....|.||:||.....:||||..:| ..|...|...:..||:.|:..::..::   :|.|
  Rat   565 DSANVLNAEKAFTSITLFNILRFPLS-MLPMVTSSILQASVSVDRLERYLGGDD---LDTS---- 621

  Fly   405 EKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIG 469
                    .::.|...          |..|:.......|..:. :..:.:||:.::.||||||:|
  Rat   622 --------AIRRVSNF----------DKAVKFSEASFTWDPDL-EATIQDVNLDIKPGQLVAVVG 667

  Fly   470 PVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKR 534
            .||||||||:.|:|||:....|.:.:.|..:|..|:.|:.|.:::||||||...::::|:.|||.
  Rat   668 TVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKA 732

  Fly   535 CALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFD 598
            |||..|||:| .||...:||:|.:|||||:.|:.||||.|:.||:|:|||||||||.|||:|:|:
  Rat   733 CALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFN 797

  Fly   599 ECM--RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNS 661
            :.:  .|.|..:..|.|||.:.||...|.||::.||.:...|:|.::|.....||:......::|
  Rat   798 KVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHS 862

  Fly   662 GGGDEIITS------------------------------PNLSRQSSALSTKSSNGSSSSLESMV 696
            |...|...:                              .|..|::.:.|::||:....||::.:
  Rat   863 GPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSL 927

  Fly   697 E-------KEKPKP---SAVSSQESRSGGQIGLSMYKKYFGA-GCGVLVFVVLIMLCIGTQILA- 749
            :       |||.|.   ..:..:|....|::..|:|.||..| |...::|::|.   .|...:|
  Rat   928 KIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILF---YGLNNVAF 989

  Fly   750 SGGDYFLSYW---------VKNTASSSTLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHN 805
            .|.:.:||.|         ..|::|...:.|..|.|:.:...||.|:.||.......::|..||.
  Rat   990 IGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHG 1054

  Fly   806 TMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWY 870
            .:...:.|..:.||.|.|:|||:|||:.|:..||:::|..:...:..|..:.|.:.::|:..|.:
  Rat  1055 QLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVF 1119

  Fly   871 LINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDN 935
            .|....:.:.:...:.||:.|||.::||::|.:||:|||||.|:.|||.|||...||..:...:.
  Rat  1120 AIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEK 1184

  Fly   936 YQDLHSSGYYTFVSTSRAFGYYLDL------FCVAYVISVILHNFFNPPLHNAGQIGLAITQALG 994
            ..|::....:::::::|.....|:|      ||.|.::.:.....      ....:|..::.||.
  Rat  1185 QIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTL------TGDVVGFVLSNALN 1243

  Fly   995 MTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYE 1059
            :|..:.|.:|.::|.|..:.:|||:.||.:::.|..:  ..:|:||..||:.|::...:..:||.
  Rat  1244 ITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPW--VTDKRPPADWPRHGEIQFNNYQVRYR 1306

  Fly  1060 PDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDL 1123
            |:.:  .||||::..|:..||||:|||||||||||.|.||| |....|.|:||.:|...||||||
  Rat  1307 PELD--LVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDL 1369

  Fly  1124 RSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFS 1188
            |.:::||||:|:||||::|.|||||.:|.|:::|:|||..||:..:|.|..||.|.::|||.|.|
  Rat  1370 RERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLS 1434

  Fly  1189 VGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDK 1253
            :|||||:||.||:||:::|||:|||||.||.:||:|||.|||.:|..|||:||||||:|||||||
  Rat  1435 IGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDK 1499

  Fly  1254 VLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASFDH 1294
            ::|:|.|.:||:|||.|||  |....|:.|..:.|..:.:|
  Rat  1500 IMVLDNGKIVEYGSPEELL--SNRGSFYLMAKEAGIENVNH 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	456/1383 (33%)
		ABC_membrane	112..364	CDD:294371	75/257 (29%)
		ABCC_MRP_domain1	434..632	CDD:213217	90/200 (45%)
		ABC_membrane	736..955	CDD:294371	66/228 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	126/221 (57%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	460/1399 (33%)
		ABC_membrane	322..589	CDD:279056	79/275 (29%)
		ABCC_MRP_domain1	633..834	CDD:213217	91/201 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		5/21 (24%)
		ABC_membrane	979..1245	CDD:279056	74/274 (27%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750