DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc1

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1377	Identity:	470/1377 - (34%)
Similarity:	734/1377 - (53%)	Gaps:	149/1377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRR- 71
            |.|..||..||.:.|.:...::.:|.:|.|:.:||:....|..:..:.......|:.|..:.|:
  Rat   207 PCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQ 271

  Fly    72 ---------------KGDS------------------GRKPSVLRVIGRVFGWRLIMSGITIAAL 103
                           ||.|                  .|.||:.:|:.:.||...:||.:..|..
  Rat   272 PVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALH 336

  Fly   104 ELGTRATVPLLLAG-----LISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAM 163
            :|       ::.||     ||..|........:...:|..||........|..|.|........|
  Rat   337 DL-------MMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGM 394

  Fly   164 KMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFL 228
            :::.||..|:|||||.::.::...:|.|::|||:|.|..||.....:.:.:|..||::.:|.|||
  Rat   395 RIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFL 459

  Fly   229 YEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERP 293
            :..:|.:...|:::::|.:|....::..|...::......|.|:::||||::||:|:|:|.||..
  Rat   460 WLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELA 524

  Fly   294 FGKLIGQMRRSEMSSIRQMNLLRG------ILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFC 352
            |...:..:|:.|:..:::...|..      :...|.:.|...|:||:    |.....|.|::||.
  Rat   525 FQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVT----VDEKNILDAKKAFV 585

  Fly   353 VTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEV 417
            ..|.:||||..:: ..|..:|...:..||::|:..|:..||...                  ..:
  Rat   586 SLALFNILRFPLN-ILPMVISSIVQASVSLKRLRIFLSHEELEP------------------DSI 631

  Fly   418 EKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAI 482
            |:.|...|.|...   :.:|.....|.:::.. .||.:..::..|.||||:|.||.|||||:.|:
  Rat   632 ERWSIKDGGGMNS---ITVKNATFTWARDEPP-TLNGITFAIPDGALVAVVGQVGCGKSSLLSAL 692

  Fly   483 LGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HG 546
            |.|:....|.|.:.|..:|..|:.|:.|.|:|:|||||.|:.:..|:.|::.|||..|||:| .|
  Rat   693 LAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSG 757

  Fly   547 DGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQL 609
            |.|.:||:|.:|||||:.|:.||||||..:|:|||||||||||.|||:|:|::.:  .|.|..:.
  Rat   758 DLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKT 822

  Fly   610 VILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL------------VESTQN-- 660
            .|||||.:.:|...|:|::|..|.:|..|:|:|:|.....||:.:            .:.::|
  Rat   823 RILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGV 887

  Fly   661 SGGGDE--------IITSP-------NLSRQSS-ALSTKSSNGSSSSLE-SMVEKEKPKPSAVSS 708
            ||.|.|        ::|..       :||..|| ::.|...:.|::.|: |.|::|..|   :..
  Rat   888 SGLGKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWK---LME 949

  Fly   709 QESRSGGQIGLSMYKKYFGA-GCGVLVFVVLIMLCIGTQILASGGDYFLSYW------VKNTASS 766
            .:....||:.||:|..|..| |..:....:.:.||.....|||  :|:||.|      |..|..:
  Rat   950 ADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALAS--NYWLSLWTDDRPAVNGTQEN 1012

  Fly   767 STLDIYYFTAINVGLVICALLRTLLFFNITM-------HSSTELHNTMFQGLSRTALYFFHTNPS 824
            ....:..:.|:.:       |:.:..|..:|       .:|..||..:.|.:.|:.:.||...||
  Rat  1013 RNFRLSVYGALGI-------LQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPS 1070

  Fly   825 GRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYL 889
            |.::|||:.:|..||.::|.|:...:....::.|.:.::.:..|...:....:.|.:::.:.||:
  Rat  1071 GNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYV 1135

  Fly   890 KTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAF 954
            .:||.:||||:|:|||:||||:.||:|:..|||...|:..|.|.|...|.:...||..:..:|..
  Rat  1136 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWL 1200

  Fly   955 GYYLDLFCVAYVISVILHNFFNPPLH--NAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVE 1017
            ...|:  ||...|.:....|.....|  :||.:||:::.:|.:|..:.|.:|.|:|:|..:.:||
  Rat  1201 AVRLE--CVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVE 1263

  Fly  1018 RVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVG 1082
            |:.||.:.:.|..:.. .|..||.:||..|::..:|..|||..|.:  .|||.::.||:..||||
  Rat  1264 RLKEYSETEKEASWQI-QETAPPSTWPHSGRVEFRDYCLRYREDLD--LVLKHINVTIEGGEKVG 1325

  Fly  1083 IVGRTGAGKSSLINALFRLSYN-DGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLD 1146
            ||||||||||||...|||::.: :|.|:||.::...||||:||.||:||||:||||||::|.|||
  Rat  1326 IVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLD 1390

  Fly  1147 PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMD 1211
            ||.||.|:::|.|||..|||..:|.||..|....:|||.|.|||||||||||||:||:.:|||:|
  Rat  1391 PFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1455

  Fly  1212 EATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASK 1276
            ||||.||.:||.|||:|||.:|:|.||||||||||||||..:|:|:|.|.:.|.|:|.|||  .:
  Rat  1456 EATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELL--QQ 1518

  Fly  1277 AKVFHGMVMQTG 1288
            ..||:.|....|
  Rat  1519 RGVFYSMAKDAG 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	465/1360 (34%)
		ABC_membrane	112..364	CDD:294371	73/262 (28%)
		ABCC_MRP_domain1	434..632	CDD:213217	90/200 (45%)
		ABC_membrane	736..955	CDD:294371	66/231 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	131/221 (59%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	470/1377 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820